2015
DOI: 10.1007/s10800-015-0892-2
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Electropolymerization of hydroxyphenylacetic acid isomers and the development of a bioelectrode for the diagnosis of bacterial meningitis

Abstract: In this work, three polymeric films derived from hydroxyphenylacetic acid isomers were electropolymerized onto the surfaces of graphite electrodes through cyclic voltammetry. Analysis of electrochemical behaviors and electrical properties of the three polymeric films were investigated and their probably structures were explored by molecular modeling. The best functionalization strategy for the incorporation and retention of adenine and guanine nitrogenous bases was the poly(3-hydroxyphenylacetic acid). It was … Show more

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Cited by 15 publications
(14 citation statements)
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“…The EB is electrochemically active and intercalates very efficiently into the double helix of DNA. This property provides an alternative mechanism for the detection of hybridization, and can be used to monitor the response of the genosensor . To confirm the capability of the proposed genosensor to quantify the molecular target, different concentrations of genomic DNA were analyzed, monitoring the BE oxidation peak (Fig.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…The EB is electrochemically active and intercalates very efficiently into the double helix of DNA. This property provides an alternative mechanism for the detection of hybridization, and can be used to monitor the response of the genosensor . To confirm the capability of the proposed genosensor to quantify the molecular target, different concentrations of genomic DNA were analyzed, monitoring the BE oxidation peak (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…The development of polymeric films and their application in biological sensors have been widely reported in literature. For the development of molecular diagnostic platforms, polymeric films are derived from hydroxyphenylacetic acid , 4‐aminophenol , 3‐aminophenol , and 4‐aminothiophenol . Electrodes modified with poly(4‐aminophenol) present two oxidizable groups (NH 2 and OH) .…”
Section: Introductionmentioning
confidence: 99%
“…The electropolymerization was conducted by cyclic voltammetry (CV), cycling the potential from 0.0 to +1.20 V. The number of potential cycles and scan rate has a direct influence on the film formation and they were investigated as followed: 25, 50 100, 150, and 200 cycles at 50 mV/s, the same scan rate as other electropolymerization studies [ 22 , 28 , 36 ]; and 25, 50, 75, and 100 mV/s with 100 cycles of potential.…”
Section: Methodsmentioning
confidence: 99%
“…Structurally, 4-HPA fits the desirable description mentioned before. It is a bifunctional monomer containing a hydroxyl (phenolic monomer) and a carboxyl group (functionality), and it has already been shown promising for the development of electrochemical platforms for biomolecules immobilization and biosensors development [ 22 , 27 , 28 ]. The mechanism is believed to occur via oxygen atoms leaving the carboxyl groups unchanged.…”
Section: Introductionmentioning
confidence: 99%
“…Rodrigues e colaboradores (Rodrigues et al, 2015) imobilizaram uma ssDNA específica para Neisseria miningitidis em eletrodos de grafite modificados com filmes eletropolimerizados derivados do ácido hidroxifenilacético, os resultados indicaram alta sensibilidade para a formação da dsDNA e foram monitorados por espectroscopia de impedância eletroquímica e por voltametria de pulso diferencial. Ensafi e colaboradores (Ensafi et al, 2015) usaram eletrodos de pasta de carbono modificados com óxido de grafeno-TO2 reduzido para imobilizar uma dsDNA para detecção de furazolidona por meio do monitoramento dos sinais de oxidação da guanina e da adenina por voltametria de pulso diferencial, estes genossensores apresentaram limite de detecção de 0,55 e 0,43 pM para adenina e guanina, respectivamente, além de uma boa seletividade e desempenho quando aplicado em amostras reais.…”
Section: Quando O Biorreceptor é Uma Enzima O Biossensor é Classificaunclassified