Electroretinographic and optical coherence tomography findings in breast cancer patients using aromatase inhibitors

Moschos, Marilita M.; Chatziralli, Irini; Sergentanis, Theodoros N.; Zagouri, Flora; Chrysikos, Dimosthenis; Ladas, Ioannis; Zografos, George

doi:10.3109/15569527.2014.1003267

Cited by 12 publications

(14 citation statements)

References 34 publications

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“…In addition to this advantage, we also need to be aware of possible side effects. Specifically, aromatase inhibitor use among women with hormone receptor-positive breast cancer was associated with a decrease in retinal nerve fiber layer thickness (37). Through pleiotropy, we can better understand how shared genetic factors between traits influence biological processes, such as drug metabolism, and subsequently, how they may aid in more effective treatments while also preventing negative side effects.…”

Section: Discussionmentioning

confidence: 99%

Genome-wide association analyses identify 139 loci associated with macular thickness in the UK Biobank cohort

Huang

Kim

2018

Human Molecular Genetics

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The macula, located near the center of the retina in the human eye, is responsible for providing critical functions, such as central, sharp vision. Structural changes in the macula are associated with many ocular diseases, including age-related macular degeneration (AMD) and glaucoma. Although macular thickness is a highly heritable trait, there are no prior reported genome-wide association studies (GWASs) of it. Here we describe the first GWAS of macular thickness, which was measured by spectral-domain optical coherence tomography using 68 423 participants from the UK Biobank cohort. We identified 139 genetic loci associated with macular thickness at genome-wide significance (P < 5 × 10 −8). The most significant loci were LINC00461 (P = 5.1 × 10 −120), TSPAN10 (P = 1.2 × 10 −118), RDH5 (P = 9.2 × 10 −105) and SLC6A20 (P = 1.4 × 10 −71). Results from gene expression demonstrated that these genes are highly expressed in the retina. Other hits included many previously reported AMD genes, such as NPLOC4 (P = 1.7 × 10 −103), RAD51B (P = 9.1 × 10 −14) and SLC16A8 (P = 1.7 × 10 −8), further providing functional significance of the identified loci. Through cross-phenotype analysis, these genetic loci also exhibited pleiotropic effects with myopia, neurodegenerative diseases (e.g. Parkinson's disease, schizophrenia and Alzheimer's disease), cancer (e.g. breast, ovarian and lung cancers) and metabolic traits (e.g. body mass index, waist circumference and type 2 diabetes). Our findings provide the first insight into the genetic architecture of macular thickness and may further elucidate the pathogenesis of related ocular diseases, such as AMD.

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Section: Discussionmentioning

confidence: 99%

Genome-wide association analyses identify 139 loci associated with macular thickness in the UK Biobank cohort

Huang

Kim

2018

Human Molecular Genetics

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“…Moschos et al investigated the impact of AIs on macular, retinal, and optic nerve function. The study concluded that AIs significantly decrease retinal nerve fibre layer thickness, retinal response density, and visual acuity [ 10 ]. There has also been evidence of crystalline retinopathy in a patient who was six months into anastrozole treatment [ 11 ].…”

Section: Reviewmentioning

confidence: 99%

Review of the Literature on Ocular Complications Associated With Aromatase Inhibitor Use

Almafreji

Smith

Peck³

2021

Cureus

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Aromatase inhibitors (AIs), such as anastrozole, letrozole, and exemestane, are commonly used as adjuvant endocrine therapy in hormone-receptive breast cancer in postmenopausal women. Their adverse effects are well documented, except for visual disturbances. The purpose of this study was to review the current literature on ocular disease linked to AI use. Due to the scarcity of published data, any suggested ophthalmic adverse events were included to increase awareness of these drugs. The ocular side effects of tamoxifen use are well documented and were not included. Cases of rare side effects such as papilloedema, macular oedema, and uveitis associated with anastrozole and letrozole have been reported. Studies demonstrating retinopathy, in the form of crystalline retinopathy, hemicentral retinal artery occlusion, and retinal haemorrhages, are also noted. All three third-generation AIs can also lead to ocular surface diseases such as corneal epithelial changes, blepharitis, and keratitis. There is slightly more literature available regarding anastrozole-related ocular diseases. Although these are likely rare side effects, we recommend a high level of clinical suspicion when assessing patients with visual symptoms and on AIs. Larger prospective studies are necessary to further investigate these complications.

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“…Moschos and colleagues 148 evaluated the effects of aromatase inhibitors (AIs) used in patients with breast cancer on peripapillary RNFL thickness, optic nerve and macular function. The study showed that AIs significantly decreased RNFL thickness (overall average, superior and inferior).…”

Section: Review Of Diseasesmentioning

confidence: 99%

The role of optical coherence tomography in therapeutics and conditions, which primarily have systemic manifestations: a narrative review

Mukherjee

Al-Fahad²,

Elsherbiny³

2019

Ophthalmol Eye Dis

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Optical coherence tomography is designed to evaluate in vivo qualitative and quantitative changes of the anterior segment, optic nerve and the retina. Initial applications of this technology were confined mainly to ophthalmic diseases. However recently, numerous studies have evaluated its use in systemic conditions and in therapeutics where, optic nerve and retinal architecture can be assessed to monitor progression of systemic conditions and its response to treatment. This is a narrative review aimed at evaluating the debate surrounding the role of spectral domain optical coherence tomography, in systemic conditions where optic nerve affection can be measured and be used in the diagnosis, monitoring and assessment of treatment effect as a non-invasive, quick, novel technique.

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Electroretinographic and optical coherence tomography findings in breast cancer patients using aromatase inhibitors

Cited by 12 publications

References 34 publications

Genome-wide association analyses identify 139 loci associated with macular thickness in the UK Biobank cohort

Genome-wide association analyses identify 139 loci associated with macular thickness in the UK Biobank cohort

Review of the Literature on Ocular Complications Associated With Aromatase Inhibitor Use

The role of optical coherence tomography in therapeutics and conditions, which primarily have systemic manifestations: a narrative review

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