Electrospinning Approaches Toward Scaffold Engineering—A Brief Overview

Boudriot, Ulrich; Dersch, Roland; Greiner, Andreas; Wendorff, Joachim H.

doi:10.1111/j.1525-1594.2006.00301.x

Cited by 235 publications

(175 citation statements)

References 28 publications

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“…In electrospinning, the bulk material of interest is dissolved in an organic solvent and subsequently pulled under the influence of an electric field through a needle and finally deposited in a non-woven pattern on a collector plate ( Figure 6). 210 Both in vitro and in vivo studies have demonstrated that osteoprogenitor cells differentiate, proliferate, and adhere in synthetic nanofibrous matrices. 211,212 Another emerging fabrication technique for nanoscale manipulation for tissue engineering applications is called nanotemplating or template synthesis.…”

Section: Physical Effectors In Synthetic Bone Scaffoldsmentioning

confidence: 99%

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Porter

Ruckh

Popat

2009

Biotechnology Progress

685

499

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Critical‐sized defects in bone, whether induced by primary tumor resection, trauma, or selective surgery have in many cases presented insurmountable challenges to the current gold standard treatment for bone repair. The primary purpose of a tissue‐engineered scaffold is to use engineering principles to incite and promote the natural healing process of bone which does not occur in critical‐sized defects. A synthetic bone scaffold must be biocompatible, biodegradable to allow native tissue integration, and mimic the multidimensional hierarchical structure of native bone. In addition to being physically and chemically biomimetic, an ideal scaffold is capable of eluting bioactive molecules (e.g., BMPs, TGF‐βs, etc., to accelerate extracellular matrix production and tissue integration) or drugs (e.g., antibiotics, cisplatin, etc., to prevent undesired biological response such as sepsis or cancer recurrence) in a temporally and spatially controlled manner. Various biomaterials including ceramics, metals, polymers, and composites have been investigated for their potential as bone scaffold materials. However, due to their tunable physiochemical properties, biocompatibility, and controllable biodegradability, polymers have emerged as the principal material in bone tissue engineering. This article briefly reviews the physiological and anatomical characteristics of native bone, describes key technologies in mimicking the physical and chemical environment of bone using synthetic materials, and provides an overview of local drug delivery as it pertains to bone tissue engineering is included. © 2009 American Institute of Chemical Engineers Biotechnol. Prog., 2009

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Section: Physical Effectors In Synthetic Bone Scaffoldsmentioning

confidence: 99%

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Porter

Ruckh

Popat

2009

Biotechnology Progress

685

499

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“…Polymeric micro/nanofibers are highly interesting materials for applications such as tissue engineering and drug delivery because the large surface area to volume ratio affords interesting new properties [1][2][3]. Electrospinning is currently one of the most versatile processes for preparing such kind of fibers since it is applicable to a wide range of materials (e.g.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable polyesters reinforced with triclosan loaded polylactide micro/nanofibers: Properties, release and biocompatibility

Valle¹,

Díaz²,

Royo³

et al. 2012

Express Polym. Lett.

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Abstract. Mechanical properties and drug release behavior were studied for three biodegradable polyester matrices (polycaprolactone, poly(nonamethylene azelate) and the copolymer derived from 1,9-nonanediol and an equimolar mixture of azelaic and pimelic acids) reinforced with polylactide (PLA) fibers. Electrospinning was used to produce suitable mats constituted by fibers of different diameters (i.e. from micro-to nanoscale) and a homogeneous dispersion of a representative hydrophobic drug (i.e. triclosan). Fabrics were prepared by a molding process, which allowed cold crystallization of PLA micro/nanofibers and hot crystallization of the polyester matrices. The orientation of PLA molecules during electrospinning favored the crystallization process, which was slightly enhanced when the diameter decreased. Incorporation of PLA micro/nanofibers led to a significant increase in the elastic modulus and tensile strength, and in general to a decrease in the strain at break. The brittle fracture was clearer when high molecular weight samples with high plastic deformation were employed. Large differences in the release behavior were detected depending on the loading process, fiber diameter size and hydrophobicity of the polyester matrix. The release of samples with the drug only loaded into the reinforcing fibers was initially fast and then became slow and sustained, resulting in longer lasting antimicrobial activity. Biocompatibility of all samples studied was demonstrated by adhesion and proliferation assays using HEp-2 cell cultures.

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“…On the contrary, electrospinning as an alternative method offers strict alignment of the resulting scaffolds (Ayres et al 2006). The technique of electrospinning results in fibers formed by electrical voltage (Boudriot et al 2006). Though, the process depends on multiple parameters, e.g.…”

Section: Matricesmentioning

confidence: 99%