Electrospinning Combined with Nonsolvent-Induced Phase Separation To Fabricate Highly Porous and Hollow Submicrometer Polymer Fibers

Nayani, Karthik; Katepalli, Hari; Sharma, Chandra Shekhar; Sharma, Ashutosh; Patil, Sandip; Venkataraghavan, R.

doi:10.1021/ie2009229

Cited by 133 publications

(109 citation statements)

References 38 publications

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“…One of the polymers, either from the core or the shell of the spun fibers, is dissolved to achieve porous nanofibers. There are a few other methods for fabricating porous nanofibers, such as phase separation by vapor, non-solvent and thermally induced phase separation [97][98][99], rapid phase separation [100,101], selective dissolution [102], and selective calcination [102,103].…”

Section: Hollow and Porous Nanofibersmentioning

confidence: 99%

Recent Advances in the Synthesis of Metal Oxide Nanofibers and Their Environmental Remediation Applications

Mondal

2017

Inventions

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Recently, wastewater treatment by photocatalytic oxidation processes with metal oxide nanomaterials and nanocomposites such as zinc oxide, titanium dioxide, zirconium dioxide, etc. using ultraviolet (UV) and visible light or even solar energy has added massive research importance. This waste removal technique using nanostructured photocatalysts is well known because of its effectiveness in disintegrating and mineralizing the unsafe organic pollutants such as organic pesticides, organohalogens, PAHs (Polycyclic Aromatic Hydrocarbons), surfactants, microorganisms, and other coloring agents in addition to the prospect of utilizing the solar and UV spectrum. The photocatalysts degrade the pollutants using light energy, which creates energetic electron in the metal oxide and thus generates hydroxyl radical, an oxidative mediator that can oxidize completely the organic pollutant in the wastewater. Altering the morphologies of metal oxide photocatalysts in nanoscale can further improve their photodegradation efficiency. Nanoscale features of the photocatalysts promote enhance light absorption and improved photon harvest property by refining the process of charge carrier generation and recombination at the semiconductor surfaces and in that way boost hydroxyl radicals. The literature covering semiconductor nanomaterials and nanocomposite-assisted photocatalysis-and, among those, metal oxide nanofibers-suggest that this is an attractive route for environmental remediation due to their capability of reaching complete mineralization of organic contaminants under mild reaction conditions such as room temperature and ambient atmospheric pressure with greater degradation performance. The main aim of this review is to highlight the most recent published work in the field of metal oxide nanofibrous photocatalyst-mediated degradation of organic pollutants and unsafe microorganisms present in wastewater. Finally, the recycling and reuse of photocatalysts for viable wastewater purification has also been conferred here and the latest examples given.

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Section: Hollow and Porous Nanofibersmentioning

confidence: 99%

Recent Advances in the Synthesis of Metal Oxide Nanofibers and Their Environmental Remediation Applications

Mondal

2017

Inventions

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“…highly porous three dimensional surface, high surface-to-volume ratios, interconnected porosity with tuneable pore dimensions, found tremendous applications in different biomedical fields [9][10][11][12][13][14][15]. Various electrospinning parameters modulate the fiber diameter and thickness, which may affect sustained and controlled release profiles [16][17][18]. To increase the diffusional path between the drug and dissolution medium, eventually the concept of multi-layered electrospun fibers was developed, which enabled better control in release [13,14].…”

Section: Introductionmentioning

confidence: 99%

Sustained drug release from multi-layered sequentially crosslinked electrospun gelatin nanofiber mesh

Laha

Sharma

Majumdar

2017

Materials Science and Engineering: C

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The aim of this study is to develop electrospun gelatin nanofibers based drug delivery carrier to achieve controlled and sustainable release of hydrophobic drug (piperine) for prolonged time. To accomplish this, we devised some strategies such as sandwiching the drug loaded gelatin nanofiber mesh with another gelatin nanofiber matrix without drug (acting as diffusion barrier), sequential crosslinking and finally, a combination of both. As fabricated multilayered electrospun nanofibers mesh was first characterized in terms of degradation study, morphology, drug-polymer interactions, thermal stability followed by studying their release kinetics in different physiological pH as per the gastrointestinal tract. Our results show that with optimized diffusional barrier support and sequential crosslinking together, a zero order sustained drug release up to 48 h may be achieved with a flexibility to vary the drug loading as per the therapeutic requirements. This work lays out the possibility of systematic design of multilayer nano-fiber mesh of a biopolymer as a drug delivery vehicle for hydrophobic drugs with a desired signature of zero order release for prolonged duration.

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“…This variant of electrospinning was successfully used for obtaining highly porous nanofibres of poly(acrylonitrile) and poly(caprolactone) [65]. Phase separation-induced porous fibre generation has also been achieved using a non-solvent, and the technique is referred to as 'non-solvent-induced phase separation' (NIPS) [66]. To achieve porous fibres, the electrospun polymer is collected in a trough containing a non-solvent for the polymer resulting in polymer precipitation.…”

Section: Scaffold Design Strategiesmentioning

confidence: 99%

The Integration of Nanotechnology and Biology for Cell Engineering: Promises and Challenges

Krishnan

Sethuraman

2013

Nanomaterials and Nanotechnology

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Introduction: Successful tissue engineering strategies leading to the regeneration of a tissue depend on many factors, starting from the choice of appropriate scaffold material, tailoring the surface functionalities and topography, providing the correct amount of chemical and mechanical stimuli at the appropriate time points, and ensuring the uniform and precise localization of cells. Further challenges arise when more than one cell type has to be employed for the effective regeneration of an organ. Importance: Though the use of nanomaterials has improved tissue engineering, many pitfalls still exist that present a roadblock in the translation of tissue engineering strategies to clinical practice. Apart from employing different materials with distinct surface functionalities and mechanical properties, various strategies have been employed to manipulate the surface topography and chemistry of scaffolds to create a biomimetic microenvironment for effective tissue regeneration. Conclusion: This review provides information about the factors influencing tissue engineering, namely geometry, chemistry, mechanics and cells, and the emerging concepts that may well represent the future of regenerative medicine. Electrospinning techniques and their variants, self-assembly, cell-printing techniques and cell sheet engineering, have all been elaborated in detail. These novel techniques may serve to overcome the challenges currently faced in tissue engineering.

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Electrospinning Combined with Nonsolvent-Induced Phase Separation To Fabricate Highly Porous and Hollow Submicrometer Polymer Fibers

Cited by 133 publications

References 38 publications

Recent Advances in the Synthesis of Metal Oxide Nanofibers and Their Environmental Remediation Applications

Recent Advances in the Synthesis of Metal Oxide Nanofibers and Their Environmental Remediation Applications

Sustained drug release from multi-layered sequentially crosslinked electrospun gelatin nanofiber mesh

The Integration of Nanotechnology and Biology for Cell Engineering: Promises and Challenges

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