Electrospinning: Methods and Development of Biodegradable Nanofibres for Drug Release

Ashammakhi, Nureddin; Wimpenny, Ian; Nikkola, L.; Yang, Yaoyao

doi:10.1166/jbn.2009.1003

Cited by 87 publications

(38 citation statements)

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“…Classically, electrospun fibers were primarily studied for (a) tissue engineering 120 due to the high morphological similarities with the natural ECM, (b) wound dressing, where phase III clinical trials were encouraging, and (c) drug delivery. 3,121,122 The further development of methods for electrospinning and the vast amount of data generated in the last decade have given rise to novel potential applications. Some of them, i.e.…”

Section: Emerging Biomedical Applications Of Electrospun Fibers and Websmentioning

confidence: 99%

Stimuli-responsive electrospun fibers and their applications

et al. 2011

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In this critical review, an overview is given on recent advances in the development and application of stimuliresponsive electrospun nanofibers.Please check this proof carefully. Our staff will not read it in detail after you have returned it. Translation errors between word-processor files and typesetting systems can occur so the whole proof needs to be read. Please pay particular attention to: tabulated material; equations; numerical data; figures and graphics; and references. If you have not already indicated the corresponding author(s) please mark their name(s) with an asterisk. Please e-mail a list of corrections or the PDF with electronic notes attached --do not change the text within the PDF file or send a revised manuscript.Please bear in mind that minor layout improvements, e.g. in line breaking, table widths and graphic placement, are routinely applied to the final version.Please note that, in the typefaces we use, an italic vee looks like this: n, and a Greek nu looks like this: n.We will publish articles on the web as soon as possible after receiving your corrections; no late corrections will be made.Please return your final corrections, where possible within 48 hours of receipt, by e-mail to: chemsocrev@rsc.org Reprints-Electronic (PDF) reprints will be provided free of charge to the corresponding author. Enquiries about purchasing paper reprints should be addressed via: http://www.rsc.org/publishing/journals/guidelines/paperreprints/. Costs for reprints are below: Stimuli-responsive electrospun nanofibers are gaining considerable attention as highly versatile tools which offer great potential in the biomedical field. In this critical review, an overview is given on recent advances made in the development and application of stimuli-responsive fibers. The specific features of these electrospun fibers are highlighted and discussed in view of the properties required for the diverse applications. Furthermore, several novel biomedical applications are discussed and the respective advantages and shortcomings inherent to stimuli-responsive electrospun fibers are addressed (136 references).

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Section: Emerging Biomedical Applications Of Electrospun Fibers and Websmentioning

confidence: 99%

Stimuli-responsive electrospun fibers and their applications

et al. 2011

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“…[ 1,2 ] Because of the high surfacearea-to-volume ratios, electrospun polymer fi bers have been investigated for a variety of applications such as catalysis, [ 3 ] fi ltration, [ 4 ] tissue engineering, [ 5 ] wound dressing, [ 6 ] and drug delivery. [ 7 ] These applications usually require different types of post-treatment after the preparation of the electrospun fi bers. Among these post-treatment methods, annealing is a useful process to control the properties of the polymer fi bers.…”

Section: Introductionmentioning

confidence: 99%

Annealing Effect on Electrospun Polymer Fibers and Their Transformation into Polymer Microspheres

Ping

Chen

Lee

et al. 2012

Macromol. Rapid Commun.

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Electrospinning is a simple and convenient technique to produce polymer fibers with diameters ranging from several nanometers to a few micrometers. Different types of polymer fibers have been prepared by electrospinning for various applications. Among different post-treatment methods of electrospun polymer fibers, the annealing process plays a critical role in controlling the fiber properties. The morphology changes of electrospun polymer fibers under annealing, however, have been little studied. Here we investigate the annealing effect of electrospun poly(methyl methacrylate) (PMMA) fibers and their transformation into PMMA microspheres. PMMA fibers with an average size of 2.39 μm are first prepared by electrospinning a 35 wt% PMMA solution in dimethylformamide. After the electrospun fibers are thermally annealed in ethylene glycol, a non-solvent for PMMA, the surfaces of the fibers undulate and transform into microspheres driven by the Rayleigh instability. The driving force of the transformation process is the minimization of the interfacial energy between the polymer fibers and ethylene glycol. The sizes of the microspheres fit well with the theoretical predictions. Longer annealing times are found to be required at lower temperatures to obtain the microspheres.

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“…With the development of tissue engineering technology, it is popular to fabricate implantable scaffolds for bridging long nerve gaps that will produce similar results of autografting (Cao et al 2009;de Ruiter et al 2009;Agnew et al 2010;Jiang et al 2010). Nanoscaled scaffolds can mimic the structure of extracellular matrix (ECM), which can provide a suitable environment to support cell regeneration (Zhang et al 2007;Sill et al 2008;Ashammakhi et al 2009). Nanofibrous scaffolds can be fabricated through many ways, such as template synthesis (Bechara et al 2010), solvent casting (Ahmed et al 2010), phase separation (Liu et al 2010), self-assembly (Shahmoon et al 2010), and electrospinning (Zhang et al 2007;Kumbar et al 2008;Sill et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Electrospun PLGA–silk fibroin–collagen nanofibrous scaffolds for nerve tissue engineering

Wang

Wei

et al. 2010

In Vitro Cell.Dev.Biol.-Animal

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Electrospun nanofibrous scaffolds varying different materials are fabricated for tissue engineering. PLGA, silk fibroin, and collagen-derived scaffolds have been proved on good biocompatibility with neurons. However, no systematic studies have been performed to examine the PLGA-silk fibroin-collagen (PLGA-SF-COL) biocomposite fiber matrices for nerve tissue engineering. In this study, different weight ratio PLGA-SF-COL (50:25:25, 30:35:35) scaffolds were produced via electrospinning. The physical and mechanical properties were tested. The average fiber diameter ranged from 280 + 26 to 168 + 21 nm with high porosity and hydrophilicity; the tensile strength was 1.76 ± 0.32 and 1.25 ± 0.20 Mpa, respectively. The results demonstrated that electrospinning polymer blending is a simple and effective approach for fabricating novel biocomposite nanofibrous scaffolds. The properties of the scaffolds can be strongly influenced by the concentration of collagen and silk fibroin in the biocomposite. To assay the cytocompatibility, Schwann cells were seeded on the scaffolds; cell attachment, growth morphology, and proliferation were studied. SEM and MTT results confirmed that PLGA-SF-COL scaffolds particularly the one that contains 50% PLGA, 25% silk fibroin, and 25% collagen is more suitable for nerve tissue engineering compared to PLGA nanofibrous scaffolds.

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Electrospinning: Methods and Development of Biodegradable Nanofibres for Drug Release

Cited by 87 publications

References 0 publications

Stimuli-responsive electrospun fibers and their applications

Stimuli-responsive electrospun fibers and their applications

Annealing Effect on Electrospun Polymer Fibers and Their Transformation into Polymer Microspheres

Electrospun PLGA–silk fibroin–collagen nanofibrous scaffolds for nerve tissue engineering

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