Electrospinning Nanofibers as a Dressing to Treat Diabetic Wounds

Abstract

Globally, diabetic mellitus (DM) is a common metabolic disease that effectively inhibits insulin production, destroys pancreatic β cells, and consequently, promotes hyperglycemia. This disease causes complications, including slowed wound healing, risk of infection in wound areas, and development of chronic wounds all of which are significant sources of mortality. With an increasing number of people diagnosed with DM, the current method of wound healing does not meet the needs of patients with diabetes. The lack of antibacterial ability and the inability to sustainably deliver necessary factors to wound areas limit its use. To overcome this, a new method of creating wound dressings for diabetic patients was developed using an electrospinning methodology. The nanofiber membrane mimics the extracellular matrix with its unique structure and functionality, owing to which it can store and deliver active substances that greatly aid in diabetic wound healing. In this review, we discuss several polymers used to create nanofiber membranes and their effectiveness in the treatment of diabetic wounds.

Electrospun organic/inorganic hybrid nanofibers for accelerating wound healing: a review

“…Unfortunately, chronic wounds, such as diabetic foot ulcers and severe burns, often necessitate prolonged and advanced medical interventions, imposing substantial financial burdens on patients. 4,5 Conventional wound treatment strategies include autografts, allografts, and xenografts. 6 However, these methods suffer from limited availability, donor shortage, and the risk of immune rejections.…”

A Novel Method to Enhance the Mechanical Properties of Polyacrylonitrile Nanofiber Mats: An Experimental and Numerical Investigation

“…This method enables the production of nanofibrous structures through a straightforward single-step process, offering precise control over fiber diameters ranging from as small as ten nanometers to several hundred nanometers. Electrospun polyacrylonitrile (PAN) nanofibers serve as a fundamental base for continuous carbon nanofibers [2], optical and sensor materials [3], nanocomposites [4], tissue scaffolds [5,6], wound healing [7,8], drug delivery systems [9], filtration solutions [10], protective gear [11,12], and intelligent textiles [13].…”