Electrospinning of Bioresorbable Polymers for Tissue Engineering Scaffolds

Boland, Eugene D.; Pawlowski, Kristin J.; Barnes, Catherine P.; Simpson, David G.; Wnek, Gary E.; Bowlin, Gary L.

doi:10.1021/bk-2006-0918.ch014

Cited by 69 publications

(70 citation statements)

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“…The lumen was seeded with smooth muscle cells and cultured for 3 days. Then, human umbilical vascular endothelial cells were injected into the lumen, and the construct was cultured for two more days to form a tissue-engineered vascular construct [36]. Apart from the vascular grafts, electrospun tubes made of biodegradable polymers have also been used to regenerate nerve defects.…”

Section: Electrospun Fibrous Scaffoldsmentioning

confidence: 99%

Electrospun nanofibrous materials for tissue engineering and drug delivery

Cui

Zhou

Chang

2010

Science and Technology of Advanced Materials

447

206

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The electrospinning technique, which was invented about 100 years ago, has attracted more attention in recent years due to its possible biomedical applications. Electrospun fibers with high surface area to volume ratio and structures mimicking extracellular matrix (ECM) have shown great potential in tissue engineering and drug delivery. In order to develop electrospun fibers for these applications, different biocompatible materials have been used to fabricate fibers with different structures and morphologies, such as single fibers with different composition and structures (blending and core-shell composite fibers) and fiber assemblies (fiber bundles, membranes and scaffolds). This review summarizes the electrospinning techniques which control the composition and structures of the nanofibrous materials. It also outlines possible applications of these fibrous materials in skin, blood vessels, nervous system and bone tissue engineering, as well as in drug delivery.

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Section: Electrospun Fibrous Scaffoldsmentioning

confidence: 99%

Electrospun nanofibrous materials for tissue engineering and drug delivery

Cui

Zhou

Chang

2010

Science and Technology of Advanced Materials

447

206

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“…Electrospun polysaccharides [31,32] and other bio-polymer based nanofibres show significant potential for a variety of biomedical applications [33][34][35] such as tissue engineering, wound dressing and cosmetics [15,34,36,37]. While oligosaccharides and polysaccharides are known to form fibres by electrospinning [15,31,32,38], the electrospinning of mono-or disaccharide-based solutions into fibres has not been reported yet.…”

Section: Introductionmentioning

confidence: 99%

Sub-micron sized saccharide fibres via electrospinning

Lepe¹,

Tucker²,

Simmons³

et al. 2015

Electrospinning

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Abstract:In this work, the production of continuous submicron diameter saccharide fibres is shown to be possible using the electrospinning process. The mechanism for the formation of electrospun polymer fibres is usually attributed to the physical entanglement of long molecular chains. The ability to electrospin continuous fibre from a low molecular weight saccharides was an unexpected phenomenon. The formation of sub-micron diameter "sugar syrup" fibres was observed in situ using highspeed video. The trajectory of the electrospun saccharide fibre was observed to follow that typical of electrospun polymers. Based on initial food grade glucose syrup tests, various solutions based on combinations of syrup components, i.e. mono-, di-and tri-saccharides, were investigated to map out materials and electrospinning conditions that would lead to the formation of fibre. This work demonstrated that sucrose exhibits the highest propensity for fibre formation during electrospinning amongst the various types of saccharide solutions studied. The possibility of electrospinning low molecular weight saccharides into sub-micron fibres has implications for the electrospinability of supramolecular polymers and other biomaterials.

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“…We prepared a uniform nanofiber with a diameter of less than 50 nm because such nanofibrous membranes could enhance both the flux and selectivity of size-exclusion membranes, and are also useful for many applications such as catalysis, as well as in electronic and photonic devices and tissue scaffolds. [12][13][14] To fabricate the desired ultrafine uniform nanofiber, we focused on the effects of salt additives in the polymer solution and humidity conditions when the polymer solution is electrospun. The electrical conductivity of the solution is known to have an important role in the formation of nonbeaded nanofibers.…”

Section: Introductionmentioning

confidence: 99%

Preparation of ultrafine uniform electrospun polyimide nanofiber

Fukushima

Karube

Kawakami

2010

Polym J

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This paper reports the preparation of bead-free ultrafine uniform nanofibers with a narrow fiber diameter distribution from fluorinated polyimide by electrospinning. Increasing the electrical conductivity of polymer solutions by the addition of salts and decreasing the discharge rate of water from the polymer by decreasing the humidity in the surrounding air decreases the diameter of the electrospun nanofiber. Ultrafine uniform nanofibers were achieved using these new salt and humidity conditions, and we successfully prepared bead-free ultrafine uniform nanofibers with a narrow range of nanoscale diameters (33±5 nm). Polymer Journal (2010) 42, 514-518; doi:10.1038/pj.2010.33; published online 28 April 2010Keywords: electrospinning; fluorinated polyimide; humidity; nanofiber; salt INTRODUCTION Nanoscale fibers prepared by the electrospinning method have received a great deal of attention, as electrospinning is capable of producing fibers with diameters in the nanometer range. 1-4 Electrospun nanofibers possess many unique properties including a large specific surface area and superior mechanical properties, and they have potential use as nanoscale building blocks. Nanofibers have been successfully prepared for many applications such as filters, optical and chemical sensors, catalyst systems, scaffolds for tissue regeneration and immobilized enzymes. 5-10 However, the applications are currently somewhat limited by the fact that most electrospun nanofibers are in the form of nonwoven mats composed of disordered nanofibers. Aligned nanofibers can be used in a variety of electrical, optical, mechanical and biomedical applications.Recently, we reported the synthesis of novel nanofibrous fluorinated polyimide membranes using an electrospinning method on a specially designed collector composed of conductive aluminum plates and glass insulator materials that can be removed from the apparatus. 11 The electrospun nanofibers were deposited across the plates and uniaxially aligned to the collector. In addition, multilayer stacked nanofibrous membranes consisting of three-dimensionally ordered nanopores were produced, and the water flux properties of the nanofibrous membranes were measured. The distance between the uniaxially aligned nanofibers decreased with deposition time, and the collector resulted in square nanopores with a regular diameter of approximately 200 nm. The nanopores prepared by the uniaxially aligned nanofibers had a significantly more regular structure than that formed by nonwoven nanofibers.The nanopore size or the distance between the uniaxially aligned nanofibers strongly depended on the nanofiber diameter. Many papers report a uniform nanofiber without beads with a diameter of

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Electrospinning of Bioresorbable Polymers for Tissue Engineering Scaffolds

Cited by 69 publications

References 0 publications

Electrospun nanofibrous materials for tissue engineering and drug delivery

Electrospun nanofibrous materials for tissue engineering and drug delivery

Sub-micron sized saccharide fibres via electrospinning

Preparation of ultrafine uniform electrospun polyimide nanofiber

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