Electrospinning of Block and Graft Type Silicone Modified Polyurethane Nanofibers

Yin, Cong; Okamoto, Rino; Kondo, Mikihisa; Tanaka, Toshihisa; Hattori, Hatsuhiko; Tanaka, Masaki; Sato, Hiromasa; Iino, Shota; Koshiro, Yoshitaka

doi:10.3390/nano9010034

Cited by 20 publications

(9 citation statements)

References 19 publications

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“…In the previous study [10], we successfully prepared 12 kinds of PUSX nanofibers under the optimized conditions, and investigated the effects of solvents and solution concentrations on the as-spun nanofibers, along with the morphological appearance.…”

Section: Resultsmentioning

confidence: 99%

“…All the electrospinning solutions were prepared by diluting the PUSX solutions (30 wt%) in DMF/MEK mixed solvent (v/v = 64:36), and stirring at room temperature for 48 h in order to obtain homogeneous solutions. All electrospinning experiments were performed at room temperature (22 °C) under the optimized parameters of our previous study [10], and the deposited nanofibers were collected on a moving metallic collector. A 10–20 kV voltage was applied while the needle tip-to-collector distance was 10 cm with an irradiation angle of 30°, and the air flow rate in the spinning environment was 0.1 mL/min.…”

Section: Methodsmentioning

confidence: 99%

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Physical Properties and In Vitro Biocompatible Evaluation of Silicone-Modified Polyurethane Nanofibers and Films

et al. 2019

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In this study, the physical properties and the biocompatibility of electrospun silicone-modified polyurethane (PUSX) nanofibers were discussed and compared with PUSX films. To investigate the effects of different structures on the physical properties, tensile strength, elongation at break, Young’s modulus, water retention, water contact angle (WCA) and thermal conductivity measurements were performed. To prove the in vitro biocompatibility of the materials, cell adhesion, cell proliferation, and cytotoxicity were studied by NIH3T3 mouse embryonic fibroblasts cells following by lactate dehydrogenase (LDH) analysis. As a conclusion, the mechanical properties, water retention, and WCA were proven to be able to be controlled and improved by adjusting the structure of PUSX. A higher hydrophobicity and lower thermal conductivity were found in PUSX nanofibers compared with polyurethane (PU) nanofibers and films. An in vitro biocompatibility evaluation shows that the cell proliferation can be performed on both PUSX nanofibers and films. However, within a short period, cells prefer to attach and entangle on PUSX nanofibers rather than PUSX films. PUSX nanofibers were proven to be a nontoxic alternative for PU nano-membranes or films in the biomedical field, because of the controllable physical properties and the biocompatibility.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Physical Properties and In Vitro Biocompatible Evaluation of Silicone-Modified Polyurethane Nanofibers and Films

et al. 2019

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“…The clinical ability of BG to bond to bone is due to the formation of a bioactive layer of hydroxyapatite (HAp) on the glass surface without the need for surrounding fibrous tissue [ 13 , 14 ]. Recently, biomaterials based on BG fiber and nanoparticles have been recognized as valuable materials in the medical field due to their high surface area and versatility [ 15 , 16 ]. As a result, they have been used in drug delivery, tissue engineering, and dentistry [ 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Physicochemical Properties, Cytocompatibility, and Biocompatibility of a Bioactive Glass Based Retrograde Filling Material

et al. 2021

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The ideal retrograde filling material that is easy to handle, has good physicochemical properties, and is biocompatible has not yet been developed. The current study reports the development of a novel bioactive glass based powder for use as a retrograde filling material that is capable of altering the consistency and hardening rate of mixtures when mixed with existing bioactive glass based cement. Furthermore, its physicochemical properties, in vitro effects on human cementoblast-like cells, and in vivo effects on inflammatory responses were evaluated. The surface of the hardened cement showed the formation of hydroxyapatite-like precipitates and calcium and silicate ions were eluted from the cement when the pH level was stabilized at 10.5. Additionally, the cement was found to be insoluble and exhibited favorable handling properties. No adverse effects on viability, proliferation, and expression of differentiated markers were observed in the in vitro experiment, and the cement was capable of inducing calcium deposition in the cells. Moreover, the cement demonstrated a lower number of infiltrated inflammatory cells compared to the other materials used in the in vivo mouse subcutaneous implantation experiment. These findings suggest that the retrograde filling material composed of bioactive glass and the novel bioactive glass based powder exhibits favorable physicochemical properties, cytocompatibility, and biocompatibility.

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“…Nanoparticles have been considered as valuable means in medicinal discipline by the reason of their high surface area to volume ratio and consequence versatility [ 34 , 35 ]. Indeed, nanoparticle-based biomaterials can interact with several biomolecules [ 36 ], resulting in being employed to several biomedical areas—e.g., drug delivery, tissue engineering, and dentistry [ 37 ].…”

Section: Introductionmentioning

confidence: 99%

Physical Properties and Biofunctionalities of Bioactive Root Canal Sealers In Vitro

Kim

Lee

et al. 2020

Nanomaterials

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Calcium silicate-based bioactive glass has received significant attention for use in various biomedical applications due to its excellent bioactivity and biocompatibility. However, the bioactivity of calcium silicate nanoparticle-incorporated bioactive dental sealer is not much explored. Herein, three commercially available bioactive root canal sealers (Endoseal MTA (EDS), Well-Root ST (WST), and Nishika Canal Sealer BG (NBG)) were compared with a resin-based control sealer (AH Plus (AHP)) in terms of physical, chemical, and biological properties. EDS and NBG showed 200 to 400 nm and 100 to 200 nm nanoparticle incorporation in the SEM image, respectively, and WST and NBG showed mineral deposition in Hank’s balanced salt solution after 28 days. The flowability and film thickness of all products met the ISO 3107 standard. Water contact angle, linear dimensional changes, and calcium and silicate ion release were significantly different among groups. All bioactive root canal sealers released calcium ions, while NBG released ~10 times more silicon ions than the other bioactive root canal sealers. Under the cytocompatible extraction range, NBG showed prominent cytocompatibility, osteogenecity, and angiogenecity compared to other sealers in vitro. These results indicate that calcium silicate nanoparticle incorporation in dental sealers could be a potential strategy for dental periapical tissue regeneration.

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Electrospinning of Block and Graft Type Silicone Modified Polyurethane Nanofibers

Cited by 20 publications

References 19 publications

Physical Properties and In Vitro Biocompatible Evaluation of Silicone-Modified Polyurethane Nanofibers and Films

Physical Properties and In Vitro Biocompatible Evaluation of Silicone-Modified Polyurethane Nanofibers and Films

Physicochemical Properties, Cytocompatibility, and Biocompatibility of a Bioactive Glass Based Retrograde Filling Material

Physical Properties and Biofunctionalities of Bioactive Root Canal Sealers In Vitro

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