Electrospinning of functional materials for biomedicine and tissue engineering

Inozemtseva, Olga A.; Salkovskiy, Yury; Severyukhina, A N; Vidyasheva, Irina V.; Petrova, N. V.; Metwally, H A; Stetciura, Inna Y.; Gorin, Dmitry A.

doi:10.1070/rcr4435

Cited by 29 publications

(20 citation statements)

References 308 publications

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“…The first is the incorporation of either a metal salt or as-prepared plasmonic nanoparticles in a polymer, and then a mixture is spun to achieve modification of nanofibers 26,27 . The second approach is based on the functionalization of the surface of polymer nanofiber substrates.…”

Section: Introductionmentioning

confidence: 99%

Nanoplasmonic Chitosan Nanofibers as Effective SERS Substrate for Detection of Small Molecules

Severyukhina

Parakhonskiy

Prikhozhdenko

et al. 2015

ACS Appl. Mater. Interfaces

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The use of surface enhanced Raman spectroscopy (SERS) is limited by low reproducibility and uniformity of the response. Solving these problems can turn the laboratory use of SERS into real-world application. In this regard, soft SERS-active substrates can enable portable instrumentation and reduce costs in the fabrication of SERS-based sensors. Here, plasmonic free-standing films made of biocompatible chitosan nanofibers and gold nanoparticles are engineered by a simple protocol varying the concentration of chloroauric acid. The concentration and distribution of gold nanoparticles in films are controlled in a predictable way, and SERS spectra for the standard 2-naphthalenethiol with concentration less than 10(-15) M are acquired in a reproducible way. The statistical analysis reveals a relatively high and locally uniform performance of SERS with an enhancement factor of 2 × 10(5) for 86% of the points on the imaged area of the SERS substrate. Potential SERS detection of small molecules, both Rhodamine 6G and d-Glucose, in the micromolar range is demonstrated.

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Section: Introductionmentioning

confidence: 99%

Nanoplasmonic Chitosan Nanofibers as Effective SERS Substrate for Detection of Small Molecules

Severyukhina

Parakhonskiy

Prikhozhdenko

et al. 2015

ACS Appl. Mater. Interfaces

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“…Moreover, the structure of the polymeric scaffold has a determinative effect on the growth behavior of the inorganic material and its resulting morphology . In view of these requirements, nonwoven polymeric materials fabricated by electrospinning (ES) are especially interesting . Such materials are structured at nanoscale level, similar to the natural extracellular matrices of living tissues, and can be prepared from a wide range of polymers .…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…3 In view of these requirements, nonwoven polymeric materials fabricated by electrospinning (ES) are especially interesting. 4 Such materials are structured at nanoscale level, similar to the natural extracellular matrices of living tissues, and can be prepared from a wide range of polymers. 5 Electrospun fibers can be successfully used as scaffolds for design of tissue engineering materials because of their unique physical chemical properties due to nanostructured nature of scaffold.…”

Section: Introductionmentioning

confidence: 99%

“…The modification of electrospun fibers allows new scaffold properties to be achieved (biologically active properties, enhanced mechanical properties, drug delivery capability), which can be beneficial for the design of functional biomedical materials. 4 The widely accepted modification technique is the incorporation of various fillers into the fiber structure. The embedding of mineral particles (calcite nanoparticles, 19 hydroxyapatite nanoparticles, 20,21 calcium phosphates CaP, 22 silicon-doped vaterite 23 ), the embedding of carbon structures (carbon nanotubes 24 and fullerenes 25 ), silver 26 or gold 11 nanoparticles and the incorporation of nanocontainers with biologically active agents (liposomes 27 ) have been carried out to obtain scaffolds with improved functionality.…”

Section: Introductionmentioning

confidence: 99%

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Vaterite coatings on electrospun polymeric fibers for biomedical applications

Savelyeva

Abalymov

Lyubun

et al. 2016

J Biomedical Materials Res

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The process of porous calcium carbonate (CaCO ) covering on electrospun poly(ε-caprolactone) (PCL) fibers is described in this study. Uniform CaCO coatings, composed of vaterite microparticles and its aggregates, were formed on PCL fibers by mineral precipitation from solution under ultrasonic treatment. The porous structure of CaCO in vaterite polymorphic form is useful for loading of various substances (drugs and nanoparticles), and this property makes vaterite an appropriate material for design of drug delivery systems. Such mineralization was implemented to attain therapeutic and/or biological activity of tissue engineering scaffolds based on electrospun PCL, by means of CaCO coatings. Various structures and polymorphs of CaCO coatings were obtained by variation of growth conditions (time of fiber incubation in work solution, ultrasonic treatment of this system). Coating homogeneity, CaCO polymorphic form, morphology, and CaCO mass can be controlled by number of successive stages of fibrous material treatment. Cytotoxicity tests showed that PCL fibers mineralized with CaCO did not release substances toxic for cells. SEM images of PCL/CaCO scaffolds cultured with cells demonstrate that scaffolds supported cell adhesion and spreading. The presented results show the new technique of controlled PCL scaffold mineralization with vaterite, and an opportunity of using PCL/CaCO as scaffolds for tissue engineering. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 94-103, 2017.

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