Electrospinning of Nanofibers from Polymer Solutions and Melts

AC and DC electrospinning of hydroxypropylmethylcellulose with polyethylene oxides as secondary polymer for improved drug dissolution

“…Electrospinning (ES) is considered to be the simplest technique to produce ultrafine fibers with average diameters of 10 nm to 10 μm from solution or melt (H. under the drawing force of the electrostatic field (Li and Xia, 2004;Reneker et al, 2007). Solventbased electrospinning has been found to be an excellent method also for the preparation of solid dispersions due to the fast and, thus, very efficient amorphization of the drug enclosed in the fibers owing a large surface area Yu et al, 2009).…”

Nanofibers Made of Globular Proteins

“…One of the attractive methods to fabricate artificial nano-and microscale polymeric fibers is by electrospinning. 3 This method is relatively simple, allowing for the manipulation of many parameters, such as fiber diameter and morphology, and enabling the formation of nonwoven mats with a controlled density. For these reasons, electrospinning has gained significant interest during the past decade as an alternative methodology for the development of biodegradable polymers for possible biomedical applications such as scaffolds for tissue engineering [4][5][6][7] and as carriers for drugs and bioactive molecules, including enzymes or even bacteria.…”

Stimuli-Responsive Polymers in Nanotechnology: Deposition and Possible Effect on Drug Release

“…Blends of PNIPAM with such biocompatible and biodegradable polymers as Poly(acrylic acid) (PAA) can be easily prepared, which yield PAA polymer matrixes with PNIPAM islands inside. Electrospinning, co-electrospinning and various solution-precipitation methods allow for manufacturing of nanofibers and nanoparticles with embedded or grafted macromolecules [1][2][3][4][5]. In addition, nanofibers and nanoparticles functionalized with drugs attract significant interest in biomedical applications [6], where PNIPAM-like stimuli-responsive materials embedded in the bulk or grafted at the surface may facilitate efficient drug delivery systems.…”