Electrospinning of natural polymers for the production of nanofibres for wound healing applications

Bombin, Adrian D. Juncos; Dunne, Nicholas; McCarthy, Helen

doi:10.1016/j.msec.2020.110994

Cited by 221 publications

(113 citation statements)

References 165 publications

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“…In addition, in terms of drug delivery, the commonly used fibrous mats are difficult to fix onto wound sites, and often fail to meet the shape of irregular wounds. Although soft hydrogels can cover irregular wounds, their poor permeability affects the exchange of nutrients such as oxygen during skin repair [ 32 ]. Compared to conventional wound dressings, the advantages of the spray include its convenience of storage, ease of preparation, and ability to fit a range of irregular wounds with high adhesion ability [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effects of EGF-modified curcumin/chitosan nano-spray on wound healing

Leng

Pang

et al. 2021

Regenerative Biomaterials

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Dermal injury, including trauma, surgical incisions, and burns, remain the most prevalent socio-economical health care issue in the clinic. Nanomedicine represents a reliable administration strategy that can promote the healing of skin lesions, but the lack of effective drug delivery methods can limit its effectiveness. In this study, we developed a novel nano-drug delivery system to treat skin defects through spraying. We prepared curcumin-loaded chitosan nanoparticles modified with epidermal growth factor (EGF) to develop an aqueous EGF-modified spray (EGF@CCN) for the treatment of dermal wounds. In vitro assays showed that the EGF@CCN displayed low cytotoxicity, and that curcumin was continuously and slowly released from the EGF@CCN. In vivo efficacy on wound healing was then evaluated using full-thickness dermal defect models in Wistar rats, showing that the EGF@CCN had significant advantages in promoting wound healing. On day 12 post-operation, skin defects in the rats of the EGF@CCN group were almost completely restored. These effects were related to the activity of curcumin and EGF on skin healing, and the high compatibility of the nano formulation. We therefore conclude that the prepared nano-scaled EGF@CCN spray represents a promising strategy for the treatment of dermal wounds.

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Section: Discussionmentioning

confidence: 99%

Therapeutic effects of EGF-modified curcumin/chitosan nano-spray on wound healing

Leng

Pang

et al. 2021

Regenerative Biomaterials

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“…In particular, the size of nanofibers and their network promote gas exchange and alienation of bacteria, while their high surface-to-volume ratio supports the delivery of therapeutic molecules [104]. Moreover, electrospun membranes show good adaptability to wound shape compared to conventional dressings, and their surface can be functionalized to enhance their bioactivity [105]. In electrospinning, a positive high voltage is applied to a viscoelastic liquid droplet of the polymer solution, deforming it into a conical shape.…”

Section: Two Major Nanotechnological Preparatory Techniques Applied Imentioning

confidence: 99%

Nanotechnology Development for Formulating Essential Oils in Wound Dressing Materials to Promote the Wound-Healing Process: A Review

Luca¹,

Pedram

Moeini

et al. 2021

Applied Sciences

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Wound healing refers to the replacement of damaged tissue through strongly coordinated cellular events. The patient’s condition and different types of wounds complicate the already intricate healing process. Conventional wound dressing materials seem to be insufficient to facilitate and support this mechanism. Nanotechnology could provide the physicochemical properties and specific biological responses needed to promote the healing process. For nanoparticulate dressing design, growing interest has focused on natural biopolymers due to their biocompatibility and good adaptability to technological needs. Polysaccharides are the most common natural biopolymers used for wound-healing materials. In particular, alginate and chitosan polymers exhibit intrinsic antibacterial and anti-inflammatory effects, useful for guaranteeing efficient treatment. Recent studies highlight that several natural plant-derived molecules can influence healing stages. In particular, essential oils show excellent antibacterial, antifungal, antioxidant, and anti-inflammatory properties that can be amplified by combining them with nanotechnological strategies. This review summarizes recent studies concerning essential oils as active secondary compounds in polysaccharide-based wound dressings.

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“…During the last years, an increasing interest in the biomedical use of polymeric nanofibers was recorded due to their high porosity, outstanding mechanical strength, and simplicity of fabrication [ 10 ]. In particular, nanofibers have been proposed as systems for the delivery of bioactive molecules [ 81 ] or in regenerative medicine [ 82 ] and also as wound dressings devices [ 83 ]. Usually, polymeric nanofibers can be fabricated by template synthesis [ 84 ], self-assembly [ 85 ], phase separation [ 86 ], and electrospinning [ 87 ].…”

Section: Nanofibers As Carriers Of Antimicrobial Natural Productsmentioning

confidence: 99%

Nanotechnologies: An Innovative Tool to Release Natural Extracts with Antimicrobial Properties

et al. 2021

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Site-Specific release of active molecules with antimicrobial activity spurred the interest in the development of innovative polymeric nanocarriers. In the preparation of polymeric devices, nanotechnologies usually overcome the inconvenience frequently related to other synthetic strategies. High performing nanocarriers were synthesized using a wide range of starting polymer structures, with tailored features and great chemical versatility. Over the last decade, many antimicrobial substances originating from plants, herbs, and agro-food waste by-products were deeply investigated, significantly catching the interest of the scientific community. In this review, the most innovative strategies to synthesize nanodevices able to release antimicrobial natural extracts were discussed. In this regard, the properties and structure of the starting polymers, either synthetic or natural, as well as the antimicrobial activity of the biomolecules were deeply investigated, outlining the right combination able to inhibit pathogens in specific biological compartments.

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Electrospinning of natural polymers for the production of nanofibres for wound healing applications

Cited by 221 publications

References 165 publications

Therapeutic effects of EGF-modified curcumin/chitosan nano-spray on wound healing

Therapeutic effects of EGF-modified curcumin/chitosan nano-spray on wound healing

Nanotechnology Development for Formulating Essential Oils in Wound Dressing Materials to Promote the Wound-Healing Process: A Review

Nanotechnologies: An Innovative Tool to Release Natural Extracts with Antimicrobial Properties

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