Electrospinning of peanut protein isolate/poly-L-lactic acid nanofibers containing tetracycline hydrochloride for wound healing

Yao, Fei; Zheng, Yanzhao; Gao, Yuhang; Du, Youwei; Chen, Fusheng

doi:10.1016/j.indcrop.2023.116262

Cited by 9 publications

(13 citation statements)

References 35 publications

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“…The PPI was developed using the alkali-dissolved acid precipitation method, and then the blend PPI/PLLA containing TCH was obtained via electrospinning. The incorporation of TCH did not affect the morphology of the nanofiber membranes, although the fiber diameter decreased when TCH content increased, while the wettability and mechanical properties improved [69]. Besides, the TCH was released from the PPI/PPLA composite nanofibers through a Fickian diffusion process.…”

Section: Wound Dressingsmentioning

confidence: 92%

“…Besides, the TCH was released from the PPI/PPLA composite nanofibers through a Fickian diffusion process. Moreover, the hemolysis rates were below 5%, which indicated the safety of the drug-loaded PPI/PLLA nanofibers, and the TCH-loaded PPI/PLLA composite nanofibers maintained the anticoagulant effect and showed low toxicity to cells [69]. The TCH/PPI/PLLA nanofibers also exhibited an inhibitory effect on S. aureus and E. coli growth and promoted skin wound healing in mice [69].…”

Section: Wound Dressingsmentioning

confidence: 98%

“…Yao et al prepared peanut protein isolate (PPI)/PLLA nanofibers loaded with f 5, 10, and 15% of tetracycline hydrochloride (TCH) for being applied as wound dressing materials [69]. The PPI was developed using the alkali-dissolved acid precipitation method, and then the blend PPI/PLLA containing TCH was obtained via electrospinning.…”

Section: Wound Dressingsmentioning

confidence: 99%

See 2 more Smart Citations

Development of Drug-Delivery Textiles Using Different Electrospinning Techniques: A Review

C. Gouveia,

Mouro

2024

Electrospinning - Theory, Applications, and Update Challenges

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Electrospinning, a remarkable and versatile technique has been related to medical textiles, aiming to produce nanomaterials for drug delivery and tissue regeneration applications. Furthermore, electrospun nanofibrous materials with unique properties as favorable pore size distribution, porosity, surface area, and wettability, along with effective mechanical properties, are the frontrunner solutions. Also, the features of the nanofibrous structures can be designed and optimized by controlling electrospinning parameters related to the solution properties, the setup parameters, and the environmental conditions to design nanofibrous textile materials for the desired applications. Further, to accomplish the required functionality of the drug-delivery systems, a rather broad range of drugs have been loaded into the nanofibers using different electrospinning techniques, namely the blending, side-by-side, coaxial, tri-axial, emulsion, and multi-needle electrospinning, in order to accomplish specific drug-release profiles of the designed nanofibrous textiles. Thus, this chapter describes the different electrospinning techniques that have been utilized in the production of the textile nanofibrous materials as the application of these materials in bone, nerve, periodontal, and vascular regeneration, as well as in wound dressings, personal-protective-equipment (PPE), and cancer treatment, providing an overview of the recent studies and highlighting the current challenges and future perspectives for their medical applications.

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Section: Wound Dressingsmentioning

confidence: 92%

Section: Wound Dressingsmentioning

confidence: 98%

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Development of Drug-Delivery Textiles Using Different Electrospinning Techniques: A Review

C. Gouveia,

Mouro

2024

Electrospinning - Theory, Applications, and Update Challenges

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“…This helps to improve their therapeutic efficacy and reduce side effects [ 253 ]. Fatemeh Koohzad et al designed a nanofibrous scaffold that uses electrostatic action to adsorb drugs, enabling the slow release of drugs at alkaline wound sites ( Figure 2 ) [ 80 ].…”

Section: Multiresponse Intelligent Drug Delivery Systems Based On Nan...mentioning

confidence: 99%

Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing

Jiang

Zheng

et al. 2023

Pharmaceutics

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Nanofiber scaffolds have emerged as a revolutionary drug delivery platform for promoting wound healing, due to their unique properties, including high surface area, interconnected porosity, excellent breathability, and moisture absorption, as well as their spatial structure which mimics the extracellular matrix. However, the use of nanofibers to achieve controlled drug loading and release still presents many challenges, with ongoing research still exploring how to load drugs onto nanofiber scaffolds without loss of activity and how to control their release in a specific spatiotemporal manner. This comprehensive study systematically reviews the applications and recent advances related to drug-laden nanofiber scaffolds for skin-wound management. First, we introduce commonly used methods for nanofiber preparation, including electrostatic spinning, sol–gel, molecular self-assembly, thermally induced phase separation, and 3D-printing techniques. Next, we summarize the polymers used in the preparation of nanofibers and drug delivery methods utilizing nanofiber scaffolds. We then review the application of drug-loaded nanofiber scaffolds for wound healing, considering the different stages of wound healing in which the drug acts. Finally, we briefly describe stimulus-responsive drug delivery schemes for nanofiber scaffolds, as well as other exciting drug delivery systems.

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“…To contrast many antibiotics’ drawbacks, such as their rapid elimination from the blood stream or the narrow therapeutic index, their topical administration has been explored by loading them in several polymeric matrices [ 158 , 159 ]. Different antibiotics have been incorporated in polymeric matrixes, such as ciprofloxacin [ 54 ], gentamycin [ 160 ], tetracycline [ 161 ], and silver sulfadiazine [ 162 ].…”

Section: Bioactive Moleculesmentioning

confidence: 99%

Natural and Synthetic Polymeric Biomaterials for Application in Wound Management

Prete,

Dattilo,

Patitucci

et al. 2023

JFB

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Biomaterials are at the forefront of the future, finding a variety of applications in the biomedical field, especially in wound healing, thanks to their biocompatible and biodegradable properties. Wounds spontaneously try to heal through a series of interconnected processes involving several initiators and mediators such as cytokines, macrophages, and fibroblasts. The combination of biopolymers with wound healing properties may provide opportunities to synthesize matrices that stimulate and trigger target cell responses crucial to the healing process. This review outlines the optimal management and care required for wound treatment with a special focus on biopolymers, drug-delivery systems, and nanotechnologies used for enhanced wound healing applications. Researchers have utilized a range of techniques to produce wound dressings, leading to products with different characteristics. Each method comes with its unique strengths and limitations, which are important to consider. The future trajectory in wound dressing advancement should prioritize economical and eco-friendly methodologies, along with improving the efficacy of constituent materials. The aim of this work is to give researchers the possibility to evaluate the proper materials for wound dressing preparation and to better understand the optimal synthesis conditions as well as the most effective bioactive molecules to load.

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Electrospinning of peanut protein isolate/poly-L-lactic acid nanofibers containing tetracycline hydrochloride for wound healing

Cited by 9 publications

References 35 publications

Development of Drug-Delivery Textiles Using Different Electrospinning Techniques: A Review

Development of Drug-Delivery Textiles Using Different Electrospinning Techniques: A Review

Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing

Natural and Synthetic Polymeric Biomaterials for Application in Wound Management

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