Electrospinning of polylactide and polycaprolactone mixtures for preparation of materials with tunable drug release properties

Biodegradable polyesters reinforced with triclosan loaded polylactide micro/nanofibers: Properties, release and biocompatibility

“…It should be noted that, in this case, k 1 became close to the value previously determined for similar PLA scaffolds (i.e. 0.09 and 0.08 min -1 ) [24]. Release data also indicate that all the triclosan was practically released in the selected medium and only an increase in the time required for complete delivery was observed when the diameter was increased (i.e.…”

“…compact or porous) and geometry of samples. However, it should be reminded that previous results on similar PCL scaffold samples [24] showed greater affinity of triclosan with the more hydrophobic PCL polymer and a lower final release percentage when PLA scaffolds were progressively enriched with PCL. As can be seen in Table 3 and Figure 8b, very few differences were found when triclosan loaded PCL matrices were reinforced with PLA micro/nanofibers.…”

“…However, at higher temperatures three Bragg peaks gradually developed at 0.542, 0.472, and 0.403 nm, indicating crystallization of PLA into the well known %-form (10 3 helical conformation) since the observed peaks could be indexed as the corresponding (200)+ (110), (203) and (015) reflections [21,22]. Although PLA hardly crystallizes, it is clear that molecular chains attain a high unidirectional orientation during electrospinning, which makes feasible a subsequent reordering process on heating [23,24]. The final degree of crystallinity was evaluated from the intensity of the above crystalline and amorphous reflections after deconvolution of the WAXD profile corresponding to the end of the cold crystallization process (Figure 4b).…”

“…Hence, the release rate constants (Table 3) and even the asymptotic release value decreased with hydrophobicity, which depended on the methylene content of the repeat unit and increased in the order P99 > COP > PCL. Samples containing triclosan loaded micro/nanofibers appear highly interesting since a relatively fast release is observed at the beginning of the delivery process; hence, a rapid antimicrobial effect should be expected; as found from the release of the similar systems [24,38]. Furthermore, a considerable amount of drug could be retained, and therefore pharmacological activity may be observed again when degradation of the polymer matrix reaches a considerable level.…”

Electrospun scaffolds of polylactide with a different enantiomeric content and loaded with anti-inflammatory and antibacterial drugs

“…Thus, diameters could be easily varied from 100 nm (i.e., nanometer scale) to 2 m (i.e., micrometer scale) by using dimethyl formamide and chloroform-acetone (2:1 v/v) mixture as solvents, respectively, when polymer concentration was kept at 10% (w/v). 29,30 Nevertheless, PLA concentration also played a determinant role because nanofibers could again be obtained when it was lower than 5% (w/v). 31 The above conclusions were taken into account in this study since a micrometer scale was preferred to detect release differences between drugs and from distinct PLA matrices.…”