Electrospinning of uniform nanofibers of Polymers of Intrinsic Microporosity (PIM-1): The influence of solution conductivity and relative humidity

Topuz, Fuat; Satilmiş, Bekir; Uyar, Tamer

doi:10.1016/j.polymer.2019.121610

Cited by 70 publications

(45 citation statements)

References 38 publications

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“…This is completely in line with the largely increased conductivity of the PLGA/TSC solutions with increased amounts of TSC (Table 2). Enhanced conductivity might have improved the stretching of the jet in the electrical field during the electrospinning procedure thus producing fibers with smaller diameter, in line with similar observations 15,16,38,39 …”

Section: Resultssupporting

confidence: 79%

“…Enhanced conductivity might have improved the stretching of the jet in the electrical field during the electrospinning procedure thus producing fibers with smaller diameter, in line with similar observations. 15,16,38,39 After treatment of the PLGA-TSC fibers for 21 days with phosphate buffer solution, the SEM showed agglomerated structures and the initial uniform morphology of the PLGA fiber mat as well as PLGA-TSC with 2.5% of HfpyTSCmB (Figure 2A,B) had disappeared.…”

Section: Resultsmentioning

confidence: 99%

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Sustained release of a thiosemicarbazone from antibacterial electrospun poly(lactic‐co‐glycolic acid) fiber mats

Barani

Haseloer

Mathur

et al. 2020

Polymers for Advanced Techs

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Antibacterial fiber mats of poly(lactic-co-glycolic acid) (PLGA) were produced in the presence of different amounts of the thiosemicarbazone (TSC) N4-(S)-(1-phenylethyl)-2-(pyridin-2-ylmethylene)hydrazine-1-carbothioamide (HfpyTSCmB) through electrospinning. Increasing amounts (0, 2.5, 5, and 10 wt%) of TSC in the PLGA spinning solution in 2,2,2-trifluoroethanol (TFE) caused an increase up to 230% in conductivity and up to 27% in viscosity. The morphology of the electrospun fibers was studied using scanning electron microscope (SEM) and showed the formation of uniform, bead free, cylindrical, and smooth fiber mats. Increasing amounts of HfpyTSCmB in the polymer solution resulted also in significant shrinking of the diameter and narrowing of the size distribution of the fibers in line with the increased conductivity of the spinning solutions. Nuclear magnetic resonance (NMR) spectroscopy and thermal methods (DSC and TG/DTA) gave proof for the chemical integrity of HfpyTSCmB in the fiber mats after the electrospinning process. The release profile of HfpyTSCmB from the fibers was examined using UV-vis absorption spectroscopy. The observed release data during 21 days was fitted to different mathematical models with the best results obtained from the Higuchi release model. The fiber mat samples showed effective antibacterial properties with inhibition zones of 0.5 to 1.5 mm against the Gram-positive Staphylococcus aureus and the Gram-negative Escherichia coli. K E Y W O R D S bacteriostatic properties, controlled drug release, nano fiber mats, PLGA, thiosemicarbazone 1 | INTRODUCTION There is an increasing demand for novel antimicrobial materials in many application areas, due to threatening human health with the growth of drug-resistant pathogens due to the biological and morphological modifications. This has led the high demand for novel drugs with enhanced, targeted activity. Thiosemicarbazones (TSC) are very promising molecules having interesting pharmacological properties with remarkable antioxidant, antiviral, antibacterial, anticancer, antitumor, antimalarial, ribonucleotide reductase enzyme inhibition, and antifungal activities when coordinated to metals but also in their absence. 1-7 TSC are synthesized through condensation of thiosemicarbazides with aldehydes or ketones. 1-3 The source thiosemicarbazides are synthesized either from secondary amines in a substitution reaction with methyl hydrazinecarbodithioate or from the addition of hydrazine to isothiocyanates. 6-13 TSC can act as ligands coordinating metal ions through their azomethine nitrogen and thiocarbonyl sulfur atoms (Scheme 1). The title TSC N4-(S)-(1-phenylethyl)-2-(pyridin-2-ylmethylene)hydrazine-1-carbothioamide (HfpyTSCmB) potentially coordinates metals through three (NNS)

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Section: Resultssupporting

confidence: 79%

Section: Resultsmentioning

confidence: 99%

Sustained release of a thiosemicarbazone from antibacterial electrospun poly(lactic‐co‐glycolic acid) fiber mats

Barani

Haseloer

Mathur

et al. 2020

Polymers for Advanced Techs

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“…The mean diameter of the fibers was calculated as 1690 ± 490 nm, suggesting the formation of microfibers, along with a small portion of nanofibers. The concentration for the electrospinning of the PAc-b-CD is higher than polymeric systems, which are generally between 5 and 30% (w/v) to able electrospun into bead-free fibers [27,28]. However, for our case, we do not use any polymeric component, and the overall system is absent from entangled chains to form physical joint domains.…”

Section: Resultsmentioning

confidence: 96%

Water-insoluble polymer-free uniform nanofibers of peracetylated cyclodextrin by electrospinning

et al. 2020

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Hydrophobic cyclodextrin (CD) nanofibers were produced by the electrospinning of peracetylated b-CD without requiring any polymer as a carrier matrix. Native b-CD was peracetylated through the reaction with acetic anhydride, and the conversion of all hydroxyl groups into acetyl was confirmed by NMR, XPS, and TGA analyses. The peracetyl modification drastically boosted the thermal stability of the b-CD molecules. The electrospinning of the peracetylated b-CD from its highly concentrated solutions (180% (w/v)) in DMF led to bead-free nanofibers, while electrospinning at the concentrations of 140 and 160% (w/v) CDs resulted in beads and beaded nanofibers, respectively. The electrospinning process parameters such as applied voltage, flow rate, and tip-to-collector distances were systematically altered to produce a uniform nanofiber structure. The flow rate had the most drastic effect on the diameter and morphology of the resultant nanofibers: A threefold rise in the fiber diameter was observed with increasing the flow rate from 0.1 to 2 mL h-1. Similarly, higher electrical field increased the fiber diameter due to higher mass flow, while boosting the tip-tocollector distance did not reveal any significant change on the fiber diameter. The stability of the peracetylated b-CD nanofibers was observed in water for 24 h without any significant morphological change; however, the dissolution of the nanofiber mat was observed with a long-time exposure to water. We demonstrated production of hydrophobic uniform CD nanofibers without using any carrier polymer.

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“…The diameter of the fiber can also be increased by increasing the electrical conductivity of the polymer solution through salt addition. Fuat Topuz et al [ 62 ] used the self-polymerizing microporous polymer (PIM) solution to prepare fibers and found that the working fluid could be electrospun at a low concentration to form fibers after ammonium salt addition. However, the diameter of the fiber slightly increased possibly because the addition of ammonium salt had increased the viscosity of the polymer solution.…”

Section: Electrospinningmentioning

confidence: 99%

Electrospun Functional Nanofiber Membrane for Antibiotic Removal in Water: Review

et al. 2021

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As a new kind of water pollutant, antibiotics have encouraged researchers to develop new treatment technologies. Electrospun fiber membrane shows excellent benefits in antibiotic removal in water due to its advantages of large specific surface area, high porosity, good connectivity, easy surface modification and new functions. This review introduces the four aspects of electrospinning technology, namely, initial development history, working principle, influencing factors and process types. The preparation technologies of electrospun functional fiber membranes are then summarized. Finally, recent studies about antibiotic removal by electrospun functional fiber membrane are reviewed from three aspects, namely, adsorption, photocatalysis and biodegradation. Future research demand is also recommended.

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Electrospinning of uniform nanofibers of Polymers of Intrinsic Microporosity (PIM-1): The influence of solution conductivity and relative humidity

Cited by 70 publications

References 38 publications

Sustained release of a thiosemicarbazone from antibacterial electrospun poly(lactic‐co‐glycolic acid) fiber mats

Sustained release of a thiosemicarbazone from antibacterial electrospun poly(lactic‐co‐glycolic acid) fiber mats

Water-insoluble polymer-free uniform nanofibers of peracetylated cyclodextrin by electrospinning

Electrospun Functional Nanofiber Membrane for Antibiotic Removal in Water: Review

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