Electrospray-based synthesis of fluorescent poly(<scp>d</scp>,<scp>l</scp>-lactide-<i>co</i>-glycolide) nanoparticles for the efficient delivery of an anticancer drug and self-monitoring its effect in drug-resistant breast cancer cells

Chatterjee, Manosree; Maity, Ritwik; Das, Souvik; Mahata, Nibedita; Basu, Biswarup; Chanda, Nripen

doi:10.1039/d0ma00646g

Cited by 15 publications

(10 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The nanoparticles were also sensitive to acidic pH, showing high drug release in acidic medium. Elevated apoptosis from the nanoparticles was observed compared to free MTX [56].…”

Section: Poly(lactic-co-glycolic Acid)mentioning

confidence: 92%

Polymer-Drug Conjugates as Nanotheranostic Agents

Manandhar

Sjöholm

Bobacka

et al. 2021

JNT

View full text Add to dashboard Cite

Since the last decade, the polymer-drug conjugate (PDC) approach has emerged as one of the most promising drug-delivery technologies owing to several benefits like circumventing premature drug release, offering controlled and targeted drug delivery, improving the stability, safety, and kinetics of conjugated drugs, and so forth. In recent years, PDC technology has advanced with the objective to further enhance the treatment outcomes by integrating nanotechnology and multifunctional characteristics into these systems. One such development is the ability of PDCs to act as theranostic agents, permitting simultaneous diagnosis and treatment options. Theranostic nanocarriers offer the opportunity to track the distribution of PDCs within the body and help to localize the diseased site. This characteristic is of particular interest, especially among those therapeutic approaches where external stimuli are supposed to be applied for abrupt drug release at the target site for localized delivery to avoid systemic side effects (e.g., Visudyne®). Thus, with the help of this review article, we are presenting the most recent updates in the domain of PDCs as nanotheranostic agents. Different methodologies utilized to design PDCs along with imaging characteristics and their applicability in a wide range of diseases, have been summarized in this article.

show abstract

“…The nanoparticles were also sensitive to acidic pH, showing high drug release in acidic medium. Elevated apoptosis from the nanoparticles was observed compared to free MTX [56].…”

Section: Poly(lactic-co-glycolic Acid)mentioning

confidence: 92%

Polymer-Drug Conjugates as Nanotheranostic Agents

Manandhar

Sjöholm

Bobacka

et al. 2021

JNT

View full text Add to dashboard Cite

show abstract

“…9). [87][88][89][90][91] The electrospray process is operated inside a closed chamber to avoid external disturbances like dirt, airflow, and humidity. The formation of nanoparticles in this method depends on parameters like concentration of the polymer, nature of the solvent, constant flow rate, needle diameter, stable voltage (above the Rayleigh limit), and a fixed distance between the needle and grounded collector, which are controllable and can be fine-tuned as per requirement.…”

Section: View Article Onlinementioning

confidence: 99%

“…11a). 91,98,99,102 Since there is no chemical modification of the biomolecules, it minimizes the chance of loss of activity. This coupling reaction is extensively studied to functionalize PLGA polymer/nanoparticles due to its intrinsic free terminal -COOH groups.…”

Section: Covalentmentioning

confidence: 99%

“…12). 90,91 The nanoparticle's shape and morphology depend on the synthesis procedure, which has an effect on the cellular uptake of the nanoparticles. A threedimensional view and line roughness graph of nanoparticles with the sub-nanometer resolution is observed under AFM in atmospheric or submerged conditions.…”

Section: Materials Advancesmentioning

confidence: 99%

“…137 Elemental characterization provides a deeper understanding of physical, chemical, and biological phenomena of the nanocarrier by the Fourier-transform infrared spectroscopy (FTIR), mass spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, X-ray photoelectron spectroscopy (XPS), and Raman spectroscopy. 90,91 The most common technique to determine the elemental composition and type of bonds between the molecules in the nano-carrier by their unique stretching frequencies is FTIR analysis (Fig. 14).…”

Section: Materials Advancesmentioning

confidence: 99%

See 2 more Smart Citations

Formulation of PLGA nano-carriers: specialized modification for cancer therapeutic applications

Chatterjee

Chanda

2022

Mater. Adv.

Self Cite

View full text Add to dashboard Cite

show abstract

Curcumin‐Encapsulated Poly(lactic‐co‐glycolic acid) Nanoparticles: A Comparison of Drug Release Kinetics from Particles Prepared via Electrospray and Nanoprecipitation

Roshan,

Haddadi‐Asl,

Ahmadi

et al. 2024

Macro Materials & Eng

View full text Add to dashboard Cite

Controlled drug release (CDR) is a significant field of research in medical sciences due to its numerous clinical advantages over traditional methods. Encapsulation of a drug in a polymeric matrix is common technique to achieve CDR. In this study, drug‐polymer particles are prepared using poly(lactic‐co‐glycolic acid) (PLGA) as the polymer and curcumin (CUR) as model drug. Two different methods, electrospray and nanoprecipitation, are used to prepare the particles, and optimal samples in each process are selected based on size and polydispersity index (PDI). Samples are characterized using various tests, and entrapment efficiency (EE%) and drug loading (DL%) are calculated using UV spectroscopy. The results showed that nanoprecipitated and electrosprayed PLGA particles successfully encapsulated CUR, with higher encapsulation efficiency (93.2%) and loading capacity (7.2%) for electrosprayed particles. The in vitro drug release showed that electrospray particles have a slower release rate due to higher encapsulation efficiency. The electrospray method turned out to be more viable for synthesizing these polymer‐drug particles due to smaller particle size, lower PDI, higher entrapment efficiency, and drug loading percentage. Finally, the antibacterial behavior of the particles proved that prepared particles provide excellent antibacterial efficacy (99.9%) and can be used as drug delivery systems.

show abstract

Electrospray-based synthesis of fluorescent poly(d,l-lactide-co-glycolide) nanoparticles for the efficient delivery of an anticancer drug and self-monitoring its effect in drug-resistant breast cancer cells

Abstract: A novel approach to synthesize anti-metabolite conjugated and intense blue fluorescence emitting smart polymeric nanoparticles is reported for the efficient delivery anticancer drug and self-monitoring its effect in the drug-resistant...

Cited by 15 publications

References 64 publications

Polymer-Drug Conjugates as Nanotheranostic Agents

Polymer-Drug Conjugates as Nanotheranostic Agents

Formulation of PLGA nano-carriers: specialized modification for cancer therapeutic applications

Curcumin‐Encapsulated Poly(lactic‐co‐glycolic acid) Nanoparticles: A Comparison of Drug Release Kinetics from Particles Prepared via Electrospray and Nanoprecipitation

Contact Info

Product

Resources

About