Electrospray tandem mass spectrometric measurements of organotin compounds

Abstract

Electrospray mass spectrometry of a series of organotin compounds in solutions of methanol are reported. Low energy collision‒induced dissociation MS/MS analysis of diagnostic precursor ions confirmed the characteristic fingerprint patterns obtained in the conventional electrospray spectra and proved to be a specific and very sensitive method for quantification of the (R3Sn)2O and the series of RnSnX4–ncompounds in environmental matrices. Concentrations of butyltin compounds (TBTX, DBTX2and MBTX3) in sediment reference materials PACS-1 and PACS-2 and butyltin and phenyltin compounds (TBTX, DBTX2, MBTX3, TPTX, DPTX2and DPTX3) in Quasimeme II biota reference material (QSP001BT) were determined. The organotin compounds were extracted from the reference materials with 1-butanol followed by dilution with methanol containing 1 mM ammonium acetate. The extracts were introduced directly into the electrospray source by a continuous flow of MeOH : H2O (60 :40). Quantitation of TBTX, DBTX2, TPTX, DPTX2and DPTX3was achieved by low energy CID tandem mass spectrometry using the Multiple Reaction Monitoring (MRM) analysis with the appropriate MS/MS transitions (positive ion electrospray ionization). Quantitation of MBTX3was achieved using a negative ion electrospray CID tandem mass spectrometry method. For all samples quantitation was achieved by use of the method of standard addition, relative extraction recoveries were determined spiking with internal standards of mono‒, di‒ and triorganotin compounds separately to different samples.

New diorganotin(IV) complexes of Schiff base derived from 4‐amino‐3‐hydrazino‐5‐mercapto‐4H‐1,2,4‐triazole: Synthesis, structural characterization, density functional theory studies, atoms‐in‐molecules analysis and antifungal activity

“…The spectrum also indicated the formation of the fragment ion centred at m / z 717 assigned as [(Ph 3 Sn) 2 OH] + , which is obtained probably as the hydrolysis product of [Ph 3 Sn] + ion, and the radical cation [SnH 2 ] +• at m / z 122. The diagnostic fragment ions observed in the mass spectra of complexes 1 and 2 have been reported previously for several complexes containing the R 2 Sn(IV) 2+ moiety …”

“…The characteristic fragment ions along with their relative abundance and probable ion structure are presented in Section and also summarized in Tables S4 and S5. The m / z values discussed have been assigned on the basis of 120 Sn, which is the most abundant isotope of tin …”

Biotransformation of tributyltin chloride to less toxic dibutyltin dichloride and monobutyltin trichloride by Klebsiella pneumoniae strain SD9

“…5). These results go hand in hand with earlier findings of Banaub et al (2004) and clearly revealed that K. pneumoniae strain SD9 biotransforms TBTCl into DBTCl 2 and finally into MBTCl 3 by utilizing it as a sole carbon source in MSM.…”

Tributyltin (TBT) biodegradation induces oxidative stress of Cunninghamella echinulata

“…The TBT fragmentation pattern had been described previously (Banoub et al 2004;Békri et al 2006). On the basis of the optimized product ions of TBT, the predicted MRM LC-MS/MS methods were developed using LightSight TM software and applied for the screening of possible metabolites.…”