Electrosprayed core-shell nanoparticles of PVP and shellac for furnishing biphasic controlled release of ferulic acid

Abstract

Coaxial electrospraying was explored to organize polymer excipients in a core-shell 43 manner for providing biphasic controlled release of active ingredient. With ferulic acid (FA) as a 44 model drug, and shellac and polyvinylpyrrolidone as the core and shell polymeric matrices, 45 core-shell nanoparticles were successfully fabricated. A series of tests were carried out to 46 characterize the prepared core-shell nanoparticles and also the nanoparticles prepared using a 47 single fluid electrospraying of the shell or core fluids alone. The core-shell nanoparticles had an 48 average diameter of 530 ± 80 nm with clear core-shell structure. The contained FA was converted 49to an amorphous state both in the core and the shell parts due to the favorable hydrogen bonding 50 between the components. In vitro dissolution tests demonstrated that the core-shell nanoparticles 51 were able to provide the desired biphasic drug controlled release profiles. Coaxial electrospraying 52 is a useful tool for the development of novel nano drug delivery systems from polymers. 53

Electrospun acid–base pair solid dispersions of quercetin

“…IL, USA) and a high-voltage power supply (ZGF 25 60 kV/2 mA, Shanghai Sute Corp., Shanghai, China) were employed in electrospinning. A homemade concentric spinneret was used to conduct both single fluid (adjusting the core or shell fluid flow rate to zero mL/h) and coaxial electrospinning processes.…”

“…31 Coaxial electrospinning can duplicate the concentric structure of the spinneret into the nanoscale. The components in the shell and core fluids are propagated almost exclusively into the shell and 25 core parts of the fibers. It is also able to 'freeze' the drug molecules into a state comparable to a liquid form.…”

“…[1][2][3][4][5] The working fluid 20 in a traditional single fluid electrospinning process is often a mixed solution of an active ingredient and a filament-forming polymer; suspensions of functional nanoparticles may also be used. [6][7][8][9][10] The active ingredient must have sufficient solubility in the chosen solvent to give an effective therapeutic dose in the 25 patient. The polymer should have good filament-forming properties and be soluble at an adequate concentration to permit the formation of fibers.…”

Improved shellac mediated nanoscale application drug release effect in a gastric-site drug delivery system

“…The study did not report a further study for the suitability of the shellac nanoparticles and sodium shellac for drug delivery. Comparing the study of Wang et al 29 and Cui et al, 30 pure shellac nanobers and shellac nanoparticles were respectively analyzed for drug delivery in vitro. Both of their whole in vitro dug release processes (pH 2 and pH 6.8) were only last for about 10 hours.…”

From Mechanical Spraying to Electrospraying-Advanced Technology Teaching in Higher Education

“…An electrospraying system is often composed of four components, i.e. the high-voltage power supply, the working fluid driving pump, the spinneret and the particle collector [20][21][22][23]. The technique essentially involves making a solution of a solute or a mixture in a volatile solvent, and ejecting this from a syringe fitted with a metal needle (the spraying head).…”