Electrosprayed Montelukast/poly (lactic-co-glycolic acid) particle based coating: A new therapeutic approach towards the prevention of in-stent restenosis

Zamani, Maedeh; Prabhakaran, Molamma P.; Varshosaz, Jaleh; Mhaisalkar, Priyadarshini S.; Ramakrishna, Seeram

doi:10.1016/j.actbio.2016.07.007

Cited by 19 publications

(11 citation statements)

References 47 publications

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“…Montelukast is a selective cysLT 1 receptor antagonist and able to preserve the proliferation and migration of coronary artery endothelial cells (Zamani et al, 2016). Drug-eluting stents coated by electrosprayed montelukast-loaded PLGA was developed to inhibit the formation of neointimal hyperplasia (Zamani et al, 2016).…”

Section: Application Of the Electrosprayed Carriers In Biomedicinementioning

confidence: 99%

Electrospraying: Possibilities and Challenges of Engineering Carriers for Biomedical Applications—A Mini Review

2019

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Electrospraying, a liquid atomization-based technique, has been used to produce and formulate micro/nanoparticular cargo carriers for various biomedical applications, including drug delivery, biomedical imaging, implant coatings, and tissue engineering. In this mini review, we begin with the main features of electrospraying methods to engineer carriers with various bioactive cargos, including genes, growth factors, and enzymes. In particular, this review focuses on the improvement of traditional electrospraying technology for the fabrication of carriers for living cells and providing a suitable condition for gene transformation. Subsequently, the major applications of the electrosprayed carriers in the biomedical field are highlighted. Finally, we finish with conclusions and future perspectives of electrospraying for high efficiency and safe production.

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Section: Application Of the Electrosprayed Carriers In Biomedicinementioning

confidence: 99%

Electrospraying: Possibilities and Challenges of Engineering Carriers for Biomedical Applications—A Mini Review

2019

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“…Leukotrienes (LTs) are a class of inflammatory mediators which are present in elevated concentrations in injured arteries following percutaneous coronary intervention. In this hindsight, montelukast (MK), a selective cysLT 1 receptor antagonist was mixed with PLGA and electrosprayed on stents (Zamani, Prabhakaran, Varshosaz, Mhaisalkar, & Ramakrishna, 2016). The MK-PLGA coatings maintained the growth of human coronary artery endothelial cells (HCAECs) while inhibiting the proliferation of human coronary artery smooth muscle cells (HCASMCs), thus preventing neointimal hyperplasia and in-stent restenosis.…”

Section: Es For Implant Coatingsmentioning

confidence: 99%

Electrospraying an enabling technology for pharmaceutical and biomedical applications: A review

Boda

Xie

2018

Journal of Aerosol Science

144

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Electrospraying (ES) is a robust and versatile technique for the fabrication of micro- and nanoparticulate materials of various compositions, morphologies, shapes, textures and sizes. The physics of ES provides a great degree of flexibility towards the materials design of choice with desired physicochemical and biological properties. Not surprising, this technology has become an important tool for the production of micro- and nanostructured materials, especially in the pharmaceutical and biomedical arena. In this review, a basic introduction to the fundamentals of ES along with a brief description of the experimental parameters that can be manipulated to obtain micro- and nanostructured materials of desired composition, size, and configuration are outlined. A greater focus of this review is to bring to light the broad range of electrosprayed materials and their applications in drug delivery, biomedical imaging, implant coating, tissue engineering, and sensing. Taken together, this review will provide an appreciation of this unique technology, which can be used to fabricate micro- and nanostructured materials with tremendous applications in the pharmaceutical and biomedical fields.

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“…Zamani's research showed that multi-drug coatings could easily be fabricated using electrospraying. The electrosprayed Montelukast/poly(lactic-co-glycolic acid) particle-based coating is a potential new therapeutic approach toward the prevention of in-stent restenosis 26 .…”

Section: Introductionmentioning

confidence: 99%

Design and testing of hydrophobic core/hydrophilic shell nano/micro particles for drug-eluting stent coating

Wang

Huang

et al. 2018

NPG Asia Mater

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In this study, we designed a novel drug-eluting coating for vascular implants consisting of a core coating of the antiproliferative drug docetaxel (DTX) and a shell coating of the platelet glycoprotein IIb/IIIa receptor monoclonal antibody SZ-21. The core/shell structure was sprayed onto the surface of 316L stainless steel stents using a coaxial electrospray process with the aim of creating a coating that exhibited a differential release of the two drugs. The prepared stents displayed a uniform coating consisting of nano/micro particles. In vitro drug release experiments were performed, and we demonstrated that a biphasic mathematical model was capable of capturing the data, indicating that the release of the two drugs conformed to a diffusion-controlled release system. We demonstrated that our coating was capable of inhibiting the adhesion and activation of platelets, as well as the proliferation and migration of smooth muscle cells (SMCs), indicating its good biocompatibility and anti-proliferation qualities. In an in vivo porcine coronary artery model, the SZ-21/DTX drug-loaded hydrophobic core/hydrophilic shell particle coating stents were observed to promote re-endothelialization and inhibit neointimal hyperplasia. This core/shell particle-coated stent may serve as part of a new strategy for the differential release of different functional drugs to sequentially target thrombosis and in-stent restenosis during the vascular repair process and ensure rapid re-endothelialization in the field of cardiovascular disease.

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Electrosprayed Montelukast/poly (lactic-co-glycolic acid) particle based coating: A new therapeutic approach towards the prevention of in-stent restenosis

Cited by 19 publications

References 47 publications

Electrospraying: Possibilities and Challenges of Engineering Carriers for Biomedical Applications—A Mini Review

Electrospraying: Possibilities and Challenges of Engineering Carriers for Biomedical Applications—A Mini Review

Electrospraying an enabling technology for pharmaceutical and biomedical applications: A review

Design and testing of hydrophobic core/hydrophilic shell nano/micro particles for drug-eluting stent coating

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