Electrospun aliphatic polycarbonates as tailored tissue scaffold materials

Welle, Alexander; Kröger, Mario; Döring, Manfred; Niederer, Kerstin; Pindel, Elvira; Chronakis, Ioannis S.

doi:10.1016/j.biomaterials.2007.01.024

Cited by 145 publications

(85 citation statements)

References 29 publications

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“…In combination with epoxides aliphatic polycarbonates are obtained [13,14]. Mostly propylene oxide (PO) and cyclohexene oxide (CHO) have been copolymerized with CO 2 to date, resulting in biodegradable materials [15,16].…”

Section: Of 12mentioning

confidence: 99%

“…After 51 days solely 3% (RT) or rather 11% (50 °C) polycarbonate units were degraded ( Figure S8). At a reaction temperature of 70 °C the degradation is faster (86% after 51 days), because 70 °C is significantly higher than the glass transition temperature of the core [16]. However, this degradation rate is still not satisfactory for a rapid purification of the poly(styrene) dispersion.…”

Section: Surfactant Properties and Degradationmentioning

confidence: 99%

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Acid-Labile Surfactants Based on Poly(ethylene glycol), Carbon Dioxide and Propylene Oxide: Miniemulsion Polymerization and Degradation Studies

et al. 2017

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Partially degradable, nonionic AB and ABA type di-and triblock copolymers based on poly(propylene carbonate) and poly(ethylene glycol) blocks were synthesized via immortal copolymerization of carbon dioxide and propylene oxide, using mPEG or PEG as a macroinitiator, and (R,R)-(salcy)-CoOBzF 5 as a catalyst in a solvent-free one-pot procedure. The amphiphilic surfactants were prepared with molecular weights (M n ) between 2800 and 10,000 g·mol −1 with narrow molecular weight distributions (1.03-1.09). The copolymers were characterized using 1 H-, 13 C-and DOSY-NMR spectroscopy and size exclusion chromatography (SEC). Surface-active properties were determined by surface tension measurements (critical micelle concentration, CMC; CMC range: 1-14 mg·mL −1 ). Degradation of the acid-labile polycarbonate blocks was investigated in aqueous solution using online 1 H-NMR spectroscopy and SEC. The amphiphilic polymers were used as surfactants in a direct miniemulsion polymerization for poly(styrene) (PS) nanoparticles with mean diameter of 270 to 940 nm. The usage of an acid-triggered precipitation of the emulsion simplified the separation of the particles from the surfactant and purification of the nanoparticles.

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Section: Of 12mentioning

confidence: 99%

Section: Surfactant Properties and Degradationmentioning

confidence: 99%

Acid-Labile Surfactants Based on Poly(ethylene glycol), Carbon Dioxide and Propylene Oxide: Miniemulsion Polymerization and Degradation Studies

et al. 2017

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“…Electrospun 3D nano-fibrous structures provide a suitable engineered 3D surface similar to the extracellular matrix, which is characterized by a wide range of pore diameters, high porosity, and high mechanical endurance [17][18][19]. Adding an electroactive coating would result in enhanced functionality over the present, passive 3D-scaffolds.…”

Section: Introductionmentioning

confidence: 99%

Nano-fiber scaffold electrodes based on PEDOT for cell stimulation

Bolin

Svennersten

Wang

et al. 2009

Sensors and Actuators B: Chemical

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119

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Electronically conductive and electrochemically active 3D-scaffolds based on electrospun poly(ethylene terephthalate) (PET) nano-fibers are reported. Vapour phase polymerization was employed to achieve an uniform and conformal coating of poly(3,4-ethylenedioxythiophone) doped with tosylate (PEDOT:tosylate) on the nano-fibers. The PEDOT coatings had a large impact on the wettability, turning the hydrophobic PET fibers super-hydrophilic. SH-SY5Y neuroblastoma cells were grown on the PEDOT coated fibers.The SH-SY5Y cells adhered well and showed healthy morphology. These electrically active scaffolds were used to induce Ca 2+ signalling in SH-SY5Y neuroblastoma cells.PEDOT:tosylate coated nano-fibers represents a class of 3D host environments that combines excellent adhesion and proliferation for neuronal cells with the possibility to regulate their signalling.

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“…PTMC is fabricated into microparticles [234], discs [235], and gels [236] alone or with polyesters or polyethers [237] for the delivery of angiogenic agents [238] and antibiotics [235]. Moreover, PCA with cyclohexane or propylene in the monomer backbone [239] or with bulky side groups linked through an ester bond to the carbons of the backbone [240] [245]. PCA are also used as denture resins.…”

Section: Polycarbonatesmentioning

confidence: 99%