Electrospun Asymmetric Membranes as Promising Wound Dressings: A Review

Melo‐Diogo, Duarte de; Correia, Ilídio J.; Moreira, André F.

doi:10.3390/pharmaceutics13020183

Cited by 44 publications

(21 citation statements)

References 89 publications

(65 reference statements)

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“… 12 , 13 Because of its intrinsic high porosity and interconnectivity, electrospun fibers have been the target of many applications in the biomedical field, including drug delivery, 14 , 15 tissue engineering, 10 , 11 , 14 and wound dressing. 16 − 18 …”

Section: Introductionmentioning

confidence: 99%

Curcuminoid-Tailored Interfacial Free Energy of Hydrophobic Fibers for Enhanced Biological Properties

Deus

França

Forero

et al. 2021

ACS Appl. Mater. Interfaces

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The ability of mimicking the extracellular matrix architecture has gained electrospun scaffolds a prominent space into the tissue engineering field. The high surface-to-volume aspect ratio of nanofibers increases their bioactivity while enhancing the bonding strength with the host tissue. Over the years, numerous polyesters, such as poly(lactic acid) (PLA), have been consolidated as excellent matrices for biomedical applications. However, this class of polymers usually has a high hydrophobic character, which limits cell attachment and proliferation, and therefore decreases biological interactions. In this way, functionalization of polyester-based materials is often performed in order to modify their interfacial free energy and achieve more hydrophilic surfaces. Herein, we report the preparation, characterization, and in vitro assessment of electrospun PLA fibers with low contents (0.1 wt %) of different curcuminoids featuring π-conjugated systems, and a central β-diketone unit, including curcumin itself. We evaluated the potential of these materials for photochemical and biomedical purposes. For this, we investigated their optical properties, water contact angle, and surface features while assessing their in vitro behavior using SH-SY5Y cells. Our results demonstrate the successful generation of homogeneous and defect-free fluorescent fibers, which are noncytotoxic, exhibit enhanced hydrophilicity, and as such greater cell adhesion and proliferation toward neuroblastoma cells. The unexpected tailoring of the scaffolds’ interfacial free energy has been associated with the strong interactions between the PLA hydrophobic sites and the nonpolar groups from curcuminoids, which indicate its role for releasing hydrophilic sites from both parts. This investigation reveals a straightforward approach to produce photoluminescent 3D-scaffolds with enhanced biological properties by using a polymer that is essentially hydrophobic combined with the low contents of photoactive and multifunctional curcuminoids

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Section: Introductionmentioning

confidence: 99%

Curcuminoid-Tailored Interfacial Free Energy of Hydrophobic Fibers for Enhanced Biological Properties

Deus

França

Forero

et al. 2021

ACS Appl. Mater. Interfaces

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“…The burst drug release from nanofibers was expected, taking into account (i) the thin fiber diameter of between 99 to 150 nm ( Figure 1 ), (ii) the high swelling index of between 800 and 1400% ( Table 4 ) and (iii) the hydrophilicity of the polymers, all of which are known to influence the release from nanofibers [ 65 ]. A faster swelling reflects the faster penetration of water molecules into the fibrous structure.…”

Section: Resultsmentioning

confidence: 99%

Multifunctional Nanofibrous Dressing with Antimicrobial and Anti-Inflammatory Properties Prepared by Needle-Free Electrospinning

et al. 2021

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An active wound dressing should address the main goals in wound treatment, which are improved wound healing and reduced infection rates. We developed novel multifunctional nanofibrous wound dressings with three active ingredients: chloramphenicol (CAM), beta-glucan (βG) and chitosan (CHI), of which βG and CHI are active nanofiber-forming biopolymers isolated from the cell walls of Saccharomyces cerevisiae and from shrimp shells, respectively. To evaluate the effect of each active ingredient on the nanofibers' morphological features and bioactivity, nanofibers with both βG and CHI, only βG, only CHI and only copolymers, polyethylene oxide (PEO) and hydroxypropylmethylcellulose (HPMC) were fabricated. All four nanofiber formulations were also prepared with 1% CAM. The needle-free NanospiderTM technique allowed for the successful production of defect-free nanofibers containing all three active ingredients. The CAM-containing nanofibers had a burst CAM-release and a high absorption capacity. Nanofibers with all active ingredients (βG, CHI and CAM) showed a concentration-dependent anti-inflammatory activity, while maintaining the antimicrobial activity of CAM. The promising anti-inflammatory properties, together with the high absorption capacity and antimicrobial effect, make these multifunctional nanofibers promising as dressings in local treatment of infected and exuding wounds, such as burn wounds.

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“…Electrospun wound dressing can be prepared to be loaded with different therapeutic or antimicrobial agents to improve wound healing. Unfortunately, the currently available wound dressings are not able to fulfil all the expectations because they are unable to restore the structural and functional properties of the native skin [117]. Nevertheless, nanofibers are presently being studied and improved for their application in tissue regeneration, both in wound healing and beauty treatment.…”

Section: Nanofibers and Scaffoldsmentioning

confidence: 99%

Nanomaterials in Skin Regeneration and Rejuvenation

Bellu

Medici

Coradduzza

et al. 2021

IJMS

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Skin is the external part of the human body; thus, it is exposed to outer stimuli leading to injuries and damage, due to being the tissue mostly affected by wounds and aging that compromise its protective function. The recent extension of the average lifespan raises the interest in products capable of counteracting skin related health conditions. However, the skin barrier is not easy to permeate and could be influenced by different factors. In the last decades an innovative pharmacotherapeutic approach has been possible thanks to the advent of nanomedicine. Nanodevices can represent an appropriate formulation to enhance the passive penetration, modulate drug solubility and increase the thermodynamic activity of drugs. Here, we summarize the recent nanotechnological approaches to maintain and replace skin homeostasis, with particular attention to nanomaterials applications on wound healing, regeneration and rejuvenation of skin tissue. The different nanomaterials as nanofibers, hydrogels, nanosuspensions, and nanoparticles are described and in particular we highlight their main chemical features that are useful in drug delivery and tissue regeneration.

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Electrospun Asymmetric Membranes as Promising Wound Dressings: A Review

Cited by 44 publications

References 89 publications

Curcuminoid-Tailored Interfacial Free Energy of Hydrophobic Fibers for Enhanced Biological Properties

Curcuminoid-Tailored Interfacial Free Energy of Hydrophobic Fibers for Enhanced Biological Properties

Multifunctional Nanofibrous Dressing with Antimicrobial and Anti-Inflammatory Properties Prepared by Needle-Free Electrospinning

Nanomaterials in Skin Regeneration and Rejuvenation

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