Electrospun Biomaterials’ Applications and Processing

Depeigne, Lucie; Zdraveva, Emilija

doi:10.4028/www.scientific.net/jbbbe.49.91

Cited by 6 publications

(8 citation statements)

References 70 publications

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“…Meanwhile, synthetic polymer nanofibers achieve structural programming, but they lack the necessary biological functions, such as biocompatibility and low cytotoxicity. Therefore, synthetic polymeric nanofibers, in their current form, serve as passive wound dressings without inherent capabilities to actively promote tissue repair and wound healing 73–75 …”

Section: Electrospinning Wound Dressing Of Synthetic Polymersmentioning

confidence: 99%

Advances in wound dressing based on electrospinning nanofibers

Zhang,

Wang,

Gao

et al. 2023

J of Applied Polymer Sci

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In recent years, there has been a significant focus on bioactive dressings suitable for treating chronic and acute wounds. Electrospinning nanofibers are considered advanced dressing options due to their high porosity and permeability to air and water, effective barrier properties against external pathogens, and excellent resemblance to the extracellular matrix for wound healing and skin regeneration. This article reviews the recent advancements in the application of electrospinning nanofibers for bioactive wound healing. The review begins with an overview of the wound healing process and electrospinning methods. It then explores the advantages and disadvantages of different synthetic and natural polymers used in the preparation of electrospinning wound dressings. The natural polymers discussed in this review include collagen, gelatin, silk fibroin, chitosan, hyaluronic acid, and sodium alginate. Additionally, the review delves into commonly used synthetic polymers like polyvinyl alcohol, polyvinyl chloride, polyethylene lactone, polylactide, and polyurethane for wound dressing applications. Furthermore, the review examines the blending of natural and synthetic polymers to create high‐performance wound dressings. It also explores the incorporation of functional additives, such as antimicrobial agents, growth factors, and natural extracts, into electrospinning nanofibers to expedite wound healing and tissue repair. In conclusion, electrospinning is an emerging technology that provides unique opportunities for designing more effective wound dressings and care products.

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Section: Electrospinning Wound Dressing Of Synthetic Polymersmentioning

confidence: 99%

Advances in wound dressing based on electrospinning nanofibers

Zhang,

Wang,

Gao

et al. 2023

J of Applied Polymer Sci

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“…A syringe pump then extrudes the solution through a small gauge needle connected to a high-voltage power supply. The collagen thread is then collected onto a conductive metal plate or mandrel [ 94 ]. The resulting threads can range in diameter from 10 nm to a few microns and can be controlled by altering the processing parameters.…”

Section: Overview Of Collagen Alignment Techniquesmentioning

confidence: 99%

“…The resulting threads can range in diameter from 10 nm to a few microns and can be controlled by altering the processing parameters. Variables related to processing parameters include voltage, extrusion speed, and needle-ground distance, whilst solution properties, such as collagen source, solvent, and concentration and environmental conditions, can affect electrospinning [ 68 , 92 , 94 , 95 ]. One of the primary benefits of electrospun collagen fibres is their enhanced mechanical properties when compared to conventional collagen scaffolds.…”

Section: Overview Of Collagen Alignment Techniquesmentioning

confidence: 99%

Collagen Alignment via Electro-Compaction for Biofabrication Applications: A Review

Carr

Chen²,

Chung³

et al. 2022

Polymers

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As the most prevalent structural protein in the extracellular matrix, collagen has been extensively investigated for biofabrication-based applications. However, its utilisation has been impeded due to a lack of sufficient mechanical toughness and the inability of the scaffold to mimic complex natural tissues. The anisotropic alignment of collagen fibres has been proven to be an effective method to enhance its overall mechanical properties and produce biomimetic scaffolds. This review introduces the complicated scenario of collagen structure, fibril arrangement, type, function, and in addition, distribution within the body for the enhancement of collagen-based scaffolds. We describe and compare existing approaches for the alignment of collagen with a sharper focus on electro-compaction. Additionally, various effective processes to further enhance electro-compacted collagen, such as crosslinking, the addition of filler materials, and post-alignment fabrication techniques, are discussed. Finally, current challenges and future directions for the electro-compaction of collagen are presented, providing guidance for the further development of collagenous scaffolds for bioengineering and nanotechnology.

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“…Electrospinning is a technology to produce fibrous and porous polymer scaffolds. The electrospun materials have a large field of potential application, owing to their large surface area, controllable surface configuration, well-modified surface, complex pore structure and good biocompatibility [ 25 , 26 , 27 , 28 , 29 , 30 ]. Electrospun membranes are widely used in the biomedical field, including tissue engineering, drug delivery, and wound healing.…”

Section: Introductionmentioning

confidence: 99%

Electrospun Silk Fibroin/Polylactic-co-glycolic Acid/Black Phosphorus Nanosheets Nanofibrous Membrane with Photothermal Therapy Potential for Cancer

Zhou

et al. 2022

Molecules

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Photothermal therapy is a promising treating method for cancers since it is safe and easily controllable. Black phosphorus (BP) nanosheets have drawn tremendous attention as a novel biodegradable thermotherapy material, owing to their excellent biocompatibility and photothermal properties. In this study, silk fibroin (SF) was used to exfoliate BP with long-term stability and good solution-processability. Then, the prepared BP@SF was introduced into fibrous membranes by electrospinning, together with SF and polylactic-co-glycolic acid (PLGA). The SF/PLGA/BP@SF membranes had relatively smooth and even fibers and the maximum stress was 2.92 MPa. Most importantly, the SF/PLGA/BP@SF membranes exhibited excellent photothermal properties, which could be controlled by the BP@SF content and near infrared (NIR) light power. The temperature of SF/PLGA/BP@SF composite membrane was increased by 15.26 °C under NIR (808 nm, 2.5 W/cm2) irradiation for 10 min. The photothermal property of SF/PLGA/BP@SF membranes significantly killed the HepG2 cancer cells in vitro, indicating its good potential for application in local treatment of cancer.

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Electrospun Biomaterials’ Applications and Processing

Cited by 6 publications

References 70 publications

Advances in wound dressing based on electrospinning nanofibers

Advances in wound dressing based on electrospinning nanofibers

Collagen Alignment via Electro-Compaction for Biofabrication Applications: A Review

Electrospun Silk Fibroin/Polylactic-co-glycolic Acid/Black Phosphorus Nanosheets Nanofibrous Membrane with Photothermal Therapy Potential for Cancer

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