Electrospun Biomolecule-Based Drug Delivery Systems

Abstract

Drug delivery, mainly a professional term in pharmaceutics, is a field of interdisciplinary intersection and integration [...]

Advanced postoperative tissue antiadhesive membranes enabled with electrospun nanofibers

“…83 Meanwhile, electrospun nanofibers are also good drug loading platforms, enabling enhanced attributes of single-layer anti-adhesive membranes through drug integration. 84 In the following part, we focus on membranes with therapeutic agents and membranes without therapeutic agents.…”

Advanced 3D Electrospinning “Xspin” System: Fabrication of Bifiber Floating Oral Pharmaceutical Scaffolds for Controlled Drug Delivery

“…In recent years, there has been significant progress in utilizing electrospinning for the creation of intricate nanostructures, including coaxial and triaxial configurations. Despite the abundant literature on multiaxial electrospinning and related core–shell structures, there is a conspicuous scarcity of reports on side-by-side electrospinning and its derivatives . This research seeks to address this gap by proposing a novel design for fabricating a side-by-side biaxial electrospinning system.…”

“…Despite the abundant literature on multiaxial electrospinning and related core−shell structures, there is a conspicuous scarcity of reports on side-by-side electrospinning and its derivatives. 9 This research seeks to address this gap by proposing a novel design for fabricating a side-by-side biaxial electrospinning system. In doing so, we aim to contribute to the advancement of electrospinning technology and expand the possibilities for creating complex nanostructures.…”

On-Demand Sequential Release of Dual Drug from pH-Responsive Electrospun Janus Nanofiber Membranes toward Wound Healing and Infection Control

“…7,8 Electrospun nanofibers serving as carriers to either currently used or newly synthesized pharmaceuticals are considered a notable alternative for traditional drug delivery. 9,10 In particular, biphasic nanofibers prepared by coaxial and emulsion electrospinning enable the incorporation of bioactive molecules or cells within layered core−shell structures and allow their delivery to target localizations. 11,12 However, as a counterpart of the core− shell nanofibers, Janus nanofibers fabricated by arranging two polymers in a side-by-side configuration have attracted considerable interest recently.…”

“…Drug delivery systems exploiting the unique capabilities of nanotechnology are promising candidates for supporting maximized therapeutic activity and minimizing undesirable side effects by regulating the time, rate, and place of drug release in the body. − Nanofibers have been found to possess several unique properties that make them highly effective for drug delivery. Due to their small diameter, high surface area, and porosity, nanofibers can enhance the efficacy of drugs through nanoeffects. , Electrospinning is one of the well-known techniques for fabricating polymeric nanofibers, and it offers a wide range of configurations that provide great flexibility in material selection, process parameters variability, and instrument setup adaptability. , This level of control ensures the development of high-quality polymeric nanofibers, which hold great promise for advanced drug delivery and tissue engineering applications. , Electrospun nanofibers serving as carriers to either currently used or newly synthesized pharmaceuticals are considered a notable alternative for traditional drug delivery. , In particular, biphasic nanofibers prepared by coaxial and emulsion electrospinning enable the incorporation of bioactive molecules or cells within layered core–shell structures and allow their delivery to target localizations. , However, as a counterpart of the core–shell nanofibers, Janus nanofibers fabricated by arranging two polymers in a side-by-side configuration have attracted considerable interest recently. − The ability of two-faced independent regions to coencapsulate multiple cargos is advantageous in the design of “intelligent” drug delivery systems. By controlling surface anisotropy, there are more options available to tailor these systems to specific needs. ,, As anticipated, the investigation on coloading therapeutic agents in electrospun Janus nanofibers for biomedical applications is still in the early stages of development .…”