Electrospun cellulose acetate fiber mats containing asiaticoside or Centella asiatica crude extract and the release characteristics of asiaticoside

Suwantong, Orawan; Ruktanonchai, Uracha; Supaphol, Pitt

doi:10.1016/j.polymer.2008.07.020

Cited by 100 publications

(64 citation statements)

References 27 publications

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“…In the same analogy, even though cyclodextrins and cyclodextrin derivatives are well known for forming self-assembling aggregates, 30-32 such a short processing time would lessen the possibility for HPβCD to form into large aggregates in case of the HPβCD fibers. As for the AC 10 fibers, the non-existence of any aggregate agreed well the work of Suwantong et al, 28 which showed that the CA fiber mats containing 40% (wt/wt) AC were smooth without any aggregate on the fiber surfaces.…”

Section: Resultssupporting

confidence: 88%

“…Comparatively, Suwantong et al 28 reported that the diameter of AC-loaded CA fibers at 40% (wt/ wt) of AC loading was 485±91 nm. The larger diameters of the AC 40 fibers (as in the Suwantong et al 28 's work) as opposed to those of the AC 10 fibers should be due to the greater amount of AC used, which could affect to the viscosity of the spinning solution in an increasing manner. The diameters of the HPβCD fibers ranged between 357±90 and 507±92 nm, while those for the FINC fibers were between 408±115 and 515±99 nm.…”

Section: Resultsmentioning

confidence: 98%

“…Generally, one of the major factors contributing to an observed increase in the diameters of electrospun fibers is an increase in the viscosity of the spinning solution. 28,33 The presence of foreign substances (i.e., AC, HPβCD, and AC/ HPβCD, in this case) would cause the viscosities of the AC-, HPβCD-, and AC/HPβCD-containing CA solutions to increase from that of the neat CA solution. As a result, larger diameters from those of the neat CA fibers were observed.…”

Section: Resultsmentioning

confidence: 99%

“…The actual amounts of AC in the specimens were first quantified according to a published method. 28 Briefly, the 1.5 cm circular disc samples were dissolved in 4 mL of 2:1 v/v acetone/DMAc. Then, 0.5 mL of solution was withdrawn and diluted in 8 mL of the phosphate buffer saline solution (PBS, pH 7.4) containing 10% (vol/vol) methanol.…”

Section: Methodsmentioning

confidence: 99%

“…These values suggested that these materials released no substances in the levels that were harmful to the cells. Suwantong et al 28 showed that CA fiber mats containing AC at 40% (wt/wt) were non-toxic to the tested fibroblasts, while Sikareepaisan et al 37 showed that alginate films containing AC at 20% (wt/wt) also posed no threat to the cells. As for the HPβCD fiber mats, the viabilities of the cells after having been submerged in the extraction media were found to range between 92 and 99%, while the values were in the range of 82 and 99% for the AC/HPβCD fiber mats.…”

Section: 폴리머 제38권 제3호 2014년mentioning

confidence: 99%

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Electrospinning of Asiaticoside/2-Hydroxypropyl-β-cyclodextrin Inclusion Complex-loaded Cellulose Acetate Fiber Mats: Release Characteristics and Potential for Use as Wound Dressing

Panichpakdee¹,

Pavasant²,

Supaphol³

2014

Polymer Korea

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Cellulose acetate (CA) fiber mats containing inclusion complexes of asiaticoside (AC) in 2-hydroxypropyl-β-cyclodextrin (HPβCD) for potential usage as wound dressings were developed. The AC/HPβCD complex-loaded CA fibers at various HPβCD to AC molar ratios of 0.5, 1, and 2 were prepared in 90:10 v/v mixture of 80% (v/v) acetic acid and N,N-dimethylacetamide (DMAc) via electrospinning. The maximum released amounts of AC depended on the HPβCD content and were much greater than those released from the AC-loaded CA fiber mat. In the in vitro study, indirect cytotoxic evaluation with human dermal fibroblasts (HDFa) showed that these materials released no substances in the levels that were harmful to the cells and the cells appeared to attach and proliferate well on these substrates. However, only the CA fiber mats containing AC/HPβCD complexes at the HPβCD to AC molar ratio of 0.5 was effective in upregulating the production of collagen of the cultured cells.

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Section: Resultssupporting

confidence: 88%

Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: 폴리머 제38권 제3호 2014년mentioning

confidence: 99%

See 3 more Smart Citations

Electrospinning of Asiaticoside/2-Hydroxypropyl-β-cyclodextrin Inclusion Complex-loaded Cellulose Acetate Fiber Mats: Release Characteristics and Potential for Use as Wound Dressing

Panichpakdee¹,

Pavasant²,

Supaphol³

2014

Polymer Korea

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Fibrous membranes of cellulose acetate and poly(vinyl pyrrolidone) by electrospinning method: Preparation and characterization

Castillo‐Ortega

Romero‐García

Medellín‐Rodríguez

et al. 2010

J of Applied Polymer Sci

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Fibrous membranes of cellulose acetate (CA), poly(vinyl pyrrolidone) (PVP) and composite membranes of these polymers, were obtained by the electrospinning method. Using systematic method, the optimal conditions for preparation of fibrous membranes were found. Both CA and PVP a concentration of 8% weight was found. The CA was dissolved in a acetone:-water solution, volume ratio 80 : 20 and the PVP is dissolved in ethanol:water solution, ratio volume 85 : 15. The flow rate for both polymers was 1.5 mL h À1. The same applied voltage value and the distance between the needle and collection plate were for polymer both, 15 kV and 15 cm respectively. The morphology of fibrous membranes and composite membranes were evaluated by scanning electron microscopy (SEM). The CA fibers showed ribon morphology, while the PVP fibers were cilindric, in both cases with diameters in the micrometer range. Thermogravimetric analysis showed that CA had a complete degradation to 445 C, while the fibrous membranes PVP required a value of temperature for degradation of up to 571 C. Fibrous composite membrane PVP/CA/PVP shows a higher value of strain at break (%), and a lower value of tensile strength (MPa) compared to CA/PVP/CA.

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In vitro biological evaluation of electrospun cellulose acetate fiber mats containing asiaticoside or curcumin

Suwantong

Ruktanonchai

Supaphol

2010

J Biomedical Materials Res

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Ultra-fine cellulose acetate (CA; M(w) approximately 30,000 Da; degree of acetyl substitution approximately 2.4) fiber mats containing either asiaticoside [from the plant Centella asiatica (L.); either in the form of a crude extract (CACE) or pure substance (PAC)] or curcumin (CM; from the plant Curcuma longa L.) were successfully prepared. The proposed use of these materials is as topical/transdermal patches or wound dressings. Here, the potential for use of these herb-loaded CA fiber mats as wound dressings was evaluated in terms of the stability and the antioxidant activity of the as-loaded herbal substances, the ability to support both the attachment and the proliferation of fibroblasts and the ability of the cultured fibroblasts to synthesize collagen. Normal human dermal fibroblasts (NHDF) were used as the reference fibroblastic cells. The results showed that the as-loaded herbal substances were stable even after the herb-loaded CA fiber mats had been aged either at room temperature or at 40 degrees C for a period of up to 4 months. The inclusion of asiaticoside [either 2% (w/w) CACE or 40% (w/w) PAC] rendered the resulting CA fiber mats their superiority in supporting the attachment, promoting the proliferation, and upregulating the production of collagen of the seeded and/or the cultured NHDF to the corresponding solvent-cast films and the neat CA fiber mats. On the other hand, the presence of CM imparted the antioxidant activity to the resulting CA fiber mats.

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Electrospun cellulose acetate fiber mats containing asiaticoside or Centella asiatica crude extract and the release characteristics of asiaticoside

Cited by 100 publications

References 27 publications

Electrospinning of Asiaticoside/2-Hydroxypropyl-β-cyclodextrin Inclusion Complex-loaded Cellulose Acetate Fiber Mats: Release Characteristics and Potential for Use as Wound Dressing

Electrospinning of Asiaticoside/2-Hydroxypropyl-β-cyclodextrin Inclusion Complex-loaded Cellulose Acetate Fiber Mats: Release Characteristics and Potential for Use as Wound Dressing

Fibrous membranes of cellulose acetate and poly(vinyl pyrrolidone) by electrospinning method: Preparation and characterization

In vitro biological evaluation of electrospun cellulose acetate fiber mats containing asiaticoside or curcumin

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