Electrospun essential oil-polycaprolactone nanofibers as antibiofilm surfaces against clinical Candida tropicalis isolates

Şahal, Gülcan; Nasseri, Behzad; Ebrahimi, A.; Bilkay, Işıl Seyis

doi:10.1007/s10529-019-02660-y

Cited by 28 publications

(11 citation statements)

References 45 publications

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“…So far a wide variety of essential oils have been electrospun, including cinnamon [39][40][41][42][43][44], oregano [45][46][47][48], peppermint [44,[49][50][51][52], clove [41,[53][54][55][56][57], thyme [58][59][60][61], lavender [62][63][64], eucalyptus [65], ginger [66], tea tree [67,68], Manuka [68], black pepper [69], and sage [69]. This review focuses on works that report the addition of EOs to polymeric solutions before conducting the electrospinning process.…”

Section: Electrospun Fibres Containing Eos and Their Applicationsmentioning

confidence: 99%

“…Clove EO has been encapsulated in electrospun fibres of PCL [53], gelatine [54], PCL/gelatine [55], polyacrylonitrile [56], alginate/PVA [41] and polyvinylpyrrolidone [57], and its efficacy has been investigated against S. aureus, E. coli, B. subtilis, Klebsiella pneumonia, Candida tropicalis, and Candida albicans. PCL/gelatine fibres (with a 7:3 PCL:gelatine ratio) containing different concentrations of clove EO (1.5%, 3.0% and 6.0% v/v) have been produced for wound care applications [55].…”

Section: Clove Essential Oilmentioning

confidence: 99%

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Electrospinning of Essential Oils

Mele

2020

Polymers

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The extensive and sometimes unregulated use of synthetic chemicals, such as drugs, preservatives, and pesticides, is posing big threats to global health, the environment, and food security. This has stimulated the research of new strategies to deal with bacterial infections in animals and humans and to eradicate pests. Plant extracts, particularly essential oils, have recently emerged as valid alternatives to synthetic drugs, due to their properties which include antibacterial, antifungal, anti-inflammatory, antioxidant, and insecticidal activity. This review discusses the current research on the use of electrospinning to encapsulate essential oils into polymeric nanofibres and achieve controlled release of these bioactive compounds, while protecting them from degradation. The works here analysed demonstrate that the electrospinning process is an effective strategy to preserve the properties of essential oils and create bioactive membranes for biomedical, pharmaceutical, and food packaging applications.

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Section: Electrospun Fibres Containing Eos and Their Applicationsmentioning

confidence: 99%

Section: Clove Essential Oilmentioning

confidence: 99%

Electrospinning of Essential Oils

Mele

2020

Polymers

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“…The antifungal activity of S. aromaticum has been demonstrated by Khan et al (2009), who reported that the ethanolic extract of clove was highly effective against C. albicans with a Minimum inhibitory concentration (MIC) value at 156 μg/mL [22]. The same result has been confirmed by Gonelimali et al (2018) and Sahal et al (2019), who detected the potency of clove extracts against C. albicans and C. tropicalis strains at concentrations of 20% w/v and 500 μl/mL, with inhibition zones diameter of 25.2 and 28 mm, respectively [23,24]. The high incidence of vaginal candidiasis among pregnant women, in addition to the emergence of resistant Candida strains to different antifungal agents, enhances the necessity to formulate novel and safe natural therapeutic agents.…”

Section: Introductionmentioning

confidence: 68%

In vitro anticandidal potency of Syzygium aromaticum (clove) extracts against vaginal candidiasis

Yassin

Mostafa

Al-Askar

2020

BMC Complement Med Ther

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Background: Candida vaginitis is a global health hazard that increases morbidity among women of childbearing age. Recent studies have revealed a high incidence of drug-resistant Candida strains. Additionally, treating Candida vulvovaginitis during pregnancy is challenging as antifungal therapy is associated with fetal abnormalities. Hence, it is important to develop novel therapeutic strategies to treat vulvovaginal candidiasis. Methods: In this study, we used the disc diffusion method to evaluate the anticandidal activity of different Syzygium aromaticum extracts (methanol, ethyl acetate, n-hexane, and diethyl ether) against C. albicans, C. glabrata, and C. tropicalis. Furthermore, gas chromatography-mass spectrometry (GC-MS) analysis of different S. aromaticum extracts was performed to determine active components exhibiting anticandidal activity. Cytotoxicity of different clove extracts against the HUH7 cell line was evaluated. Results: The ethyl acetate extract exhibited the highest antifungal activity against C. albicans, C. glabrata, and C. tropicalis with inhibition zone diameters of 20.9, 14.9, and 30.7 mm, respectively. The minimum inhibitory concentration of the S. aromaticum ethyl acetate extract was 250 μg/disc against C. tropicalis, and 500 μg/disc against C. albicans and C. glabrata, while the minimum fungicidal concentration was 0.5 mg/disc against C. tropicalis and 1 mg/disc against the C. albicans and C. glabrata. GC-MS analysis of the ethyl acetate extract revealed the main bioactive compound as eugenol (58.88%), followed by eugenyl acetate (23.86%), transcaryophyllene (14.44%), and α-humulene (1.88%). The cytotoxicity assay indicated that the diethyl ether extract demonstrated the lowest toxicological effect against the HUH7 cell line, with a relative IC 50 of 62.43 μg/ml; the methanolic extract demonstrated a higher toxicity (IC 50 , 24.17 μg/ml). Conclusion: As the S. aromaticum extract exhibited high antifungal activity at low concentrations, it can be a potential source of natural antifungal drugs.

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“…When the diameters of nanofibers are reduced to nano size, their mechanical properties such as Young's modulus and tensile strength can improve as compared to the micron size due to high surface area/volume ratios . It makes polymeric nanofibers attractive for many different applications . Moreover, nanofibers have high functionalization potential due to their large specific surface areas.…”

Section: Introductionmentioning

confidence: 99%

“…[11,12] It makes polymeric nanofibers attractive for many different applications. [13][14][15][16] Moreover, nanofibers have high functionalization potential due to their large specific surface areas. Among the production methods of nanofibers used in many application areas due to these attractive properties, the electrospinning method is considered to be a highly efficient technique for obtaining polymeric matrix nanostructures.…”

mentioning

confidence: 99%

Flexible poly(styrene‐ethylene‐butadiene‐styrene) hybrid nanofibers for bioengineering and water filtration applications

Avcı

Akkulak

Gergeroglu

et al. 2020

J of Applied Polymer Sci

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Among the thermoplastic elastomers that play important roles in the polymer industry due to their superior properties, styrene‐based species and polyurethane block copolymers are of great interest. Poly(styrene‐ethylene‐butadiene‐styrene) (SEBS) as a triblock copolymer seems to have the potential to meet many demands in different applications due to various industrial requirements where durability, biocompatibility, breaking elongation, and interfacial adhesion are important. In this study, the SEBS triblock copolymer was functionalized with natural (Satureja hortensis, SH) and synthetic (nanopowder, TiO2) agents to obtain composite nanofibers by electrospinning and electrospraying methods for use in biomedical and water filtration applications. The results were compared with thermoplastic polyurethane (TPU) composite nanofibers, which are commonly used in these fields. Here, functionalized SEBS nanofibers exhibited antibacterial effect while at the same time improving cell viability. In addition, because of successful water filtration by using the SEBS composite nanofibers, the material may have a good potential to be used comparably to TPU for the application.

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Electrospun essential oil-polycaprolactone nanofibers as antibiofilm surfaces against clinical Candida tropicalis isolates

Cited by 28 publications

References 45 publications

Electrospinning of Essential Oils

Electrospinning of Essential Oils

In vitro anticandidal potency of Syzygium aromaticum (clove) extracts against vaginal candidiasis

Flexible poly(styrene‐ethylene‐butadiene‐styrene) hybrid nanofibers for bioengineering and water filtration applications

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