Electrospun metronidazole-loaded nanofibers for vaginal drug delivery

Tuğcu-Demiröz, Fatmanur; Saar, Sinem; Tort, Serdar; Acartürk, Füsun

doi:10.1080/03639045.2020.1767125

Cited by 46 publications

(26 citation statements)

References 78 publications

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“…Ex vivo permeability studies revealed the enhanced permeability of metronidazole through the cow vaginal mucosa from metronidazole-loaded nanofibers compared to the solution and gel systems. This increment was associated with the hydrophilic properties of PVP resulting in rapid wetting of nanofibers [86]. A similar study was performed by Nematpour and colleagues with the developed nanofiber-loaded clotrimazole for local treatment of VVC.…”

Section: Vaginal Nanofibersmentioning

confidence: 61%

Promising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update

et al. 2020

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An optimal host–microbiota interaction in the human vagina governs the reproductive health status of a woman. The marked depletion in the beneficial Lactobacillus sp. increases the risk of infection with sexually transmitted pathogens, resulting in gynaecological issues. Vaginal infections that are becoming increasingly prevalent, especially among women of reproductive age, require an effective concentration of antimicrobial drugs at the infectious sites for complete disease eradication. Thus, topical treatment is recommended as it allows direct therapeutic action, reduced drug doses and side effects, and self-insertion. However, the alterations in the physiological conditions of the vagina affect the effectiveness of vaginal drug delivery considerably. Conventional vaginal dosage forms are often linked to low retention time in the vagina and discomfort which significantly reduces patient compliance. The lack of optimal prevention and treatment approaches have contributed to the unacceptably high rate of recurrence for vaginal diseases. To combat these limitations, several novel approaches including nano-systems, mucoadhesive polymeric systems, and stimuli-responsive systems have been developed in recent years. This review discusses and summarises the recent research progress of these novel approaches for vaginal drug delivery against various vaginal diseases. An overview of the concept and challenges of vaginal infections, anatomy and physiology of the vagina, and barriers to vaginal drug delivery are also addressed.

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Section: Vaginal Nanofibersmentioning

confidence: 61%

Promising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update

et al. 2020

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“…The knowledge of the thickness measurement conditions (mainly the applied pressure) should help, but usually, this information is missing. [9,[27][28][29][30][31][32][33][34][35][36][37][38][39] The underestimation of this aspect, affecting almost all the studies about tensile testing of nanofibers, prevents any reliable comparison. As a consequence, the state-of-the-art on the topic lacks, despite the widespread growth and use of such nanomaterials.…”

Section: Introductionmentioning

confidence: 99%

How Nanofibers Carry the Load: Toward a Universal and Reliable Approach for Tensile Testing of Polymeric Nanofibrous Membranes

Maccaferri

Cocchi

Mazzocchetti

et al. 2021

Macro Materials & Eng

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Nanofibrous nonwovens show high versatility and outstanding properties, with reduced weight. Porous morphology, high material flexibility and deformability challenge their mechanical testing, severely affecting results reliability. Still today, a specific technical standard method to carry out tensile testing of nonwoven nanofibrous mats is lacking, as well as studies concerning tensile test data reliability. In this work, an accurate, systematic, and critical study is presented concerning tensile testing of nonwovens, using electrospun Nylon 66 random nanofibrous mats as a case study. Nanofibers diameter and specimen geometry are investigated to thoroughly describe the nanomat tensile behavior, also considering the polymer thermal properties, and the nanofibers crossings number as a function of the nanofibers diameter. Below a threshold value, which lies between 150 and 250 nm, the overall mat mechanical behavior changes from ductile to brittle, showing enhanced elastic modulus for a high number of nanofibers crossings. While specimen geometry does not affect tensile results. Stress–strain data are analyzed using a phenomenological data fitting model to better interpret the tensile behavior. The experimental results demonstrate the high reliability of the proposed mass‐based load normalization, providing a simple, effective, and universally suitable method for obtaining high reproducible tensile stress–strain curves.

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“…Nevertheless, the nanofibers released an effective level (higher than the minimum inhibitory concentrations (MICs)) for only 4 days. Tugzu-Demiroz et al [ 35 ] prepared metronidazole-loaded nanofibers via electrospinning, and proposed that metronidazole-loaded nanofibers can be a potential drug delivery system for the treatment of bacterial vaginosis. Srithep et al [ 36 ] developed metronidazole-loaded polylactide stereocomplex electrospun nanofiber mats for treatment of periodontal disease.…”

Section: Discussionmentioning

confidence: 99%

Fabrication of Drug-Eluting Polycaprolactone/poly(lactic-co-glycolic Acid) Prolapse Mats Using Solution-Extrusion 3D Printing and Coaxial Electrospinning Techniques

Chen

Lin

et al. 2021

Polymers

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We developed biodegradable drug-eluting prolapse mats using solution-extrusion 3D printing and coaxial electrospinning techniques. The mats were composed of polycaprolactone (PCL) mesh and lidocaine-, estradiol-, metronidazole-, and connective tissue growth factor (CTGF)-incorporated poly(lactic-co-glycolic acid) (PLGA) nanofibers that mimic the structure of the natural extracellular matrix of most connective tissues. The mechanical properties of degradable prolapse membrane were assessed and compared to commercial non-degradable polypropylene knitted meshes clinically used for pelvic organ prolapse (POP) repair. The release behaviors of the drug-loaded hybrid degradable membranes were also characterized. The experimental results suggest that 3D-printed PCL meshes exhibited comparable strengths to commercial POP meshes and survived through 10,000 cycles of fatigue test without breakage. Hybrid PCL meshes/PLGA nanofibrous membranes provided a sustainable release of metronidazole, lidocaine, and estradiol for 4, 25, and 30 days, respectively, in vitro. The membranes further liberated high levels of CTGF for more than 30 days. The animal tests show that the mechanical property of PCL mesh decreased with time, mainly due to degradation of the polymers post-implantation. No adverse effect of the mesh/nanofibers was noted in the histological images. By adopting solution-extrusion 3D printing and coaxial electrospinning, degradable drug-eluting membranes can be fabricated for POP applications.

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Electrospun metronidazole-loaded nanofibers for vaginal drug delivery

Cited by 46 publications

References 78 publications

Promising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update

Promising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update

How Nanofibers Carry the Load: Toward a Universal and Reliable Approach for Tensile Testing of Polymeric Nanofibrous Membranes

Fabrication of Drug-Eluting Polycaprolactone/poly(lactic-co-glycolic Acid) Prolapse Mats Using Solution-Extrusion 3D Printing and Coaxial Electrospinning Techniques

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