Electrospun nanofibers as a wound dressing for treating diabetic foot ulcer

Liu, Yan; Zhou, Shiya; Gao, Yanlin; Zhai, Yinglei

doi:10.1016/j.ajps.2018.04.004

Cited by 174 publications

(111 citation statements)

References 124 publications

Supporting

Mentioning

103

Contrasting

Unclassified

Order By: Relevance

“…Bixin-load PCL nanofibers reduce the length of time of wound closure more than the PCL nanofibers. Other natural curcumin compounds derived from turmeric have many biological activities that have been proven such as anti-tumor, antioxidant, and anti-inflammatory (Liu et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…The choice of intervention can be adjusted according to the available health facilities and services in the surrounding environment. (Liu et al, 2018) (Liu et al, 2018) Article review 1. Electrospun nanofibers as a wound dressing to treat diabetic foot ulcers…”

Section: Discussionmentioning

confidence: 99%

“…The principle use for wound care is managing the moist wound condition. (Liu, Zhou, Gao, & Zhai, 2018). If the moisture of the wound is managed properly, then it will speed up the healing process.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Management of Diabetic Foot Ulcers Using the Wound Treatment Techniques of Modern Dressing: A Systematic Review

Alfaqih

Sinawang

Faizah

et al. 2020

J. Ners

View full text Add to dashboard Cite

Background: One of the complications caused by diabetes mellitus is the problem of diabetic foot ulcers (DFU). The management of the DFU problem can be carried out through the wound care focused on the foot using modern dressings. This research was to determine the effectiveness of modern dressings on the healing process of diabetic foot ulcers.Methods: The methods used in arranging this systematic review were (1) the identification of interventions in the literature, (2) the identification of relevant literature based on the topic and title, (3) obtaining the literature in full-text form and (4) the analysis of the results from the various interventions in the literature.Result: The literature search was carried out in several databases such as Scopus, Google Scholar and Pubmed. The samples in this article were research about the effect of modern dressings in the treatment of diabetic foot ulcers. A total of 22 evidence bases found 10 studies using the pre-experimental method, 3 RCTs, 2 quasi-experiments, 2 articles / systematic reviews, 2 perspective studies, 1 medical report, 1 case study and 1 vitro and vivo study.Conclusion: Based on the review, it explains that the research on modern dressings using nanocrystalline silver ion and curcumin can improves wound recovery by increasing the transformation rate of the ß1 growth factor, which is a protein involved in cell growth and proliferation.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Management of Diabetic Foot Ulcers Using the Wound Treatment Techniques of Modern Dressing: A Systematic Review

Alfaqih

Sinawang

Faizah

et al. 2020

J. Ners

View full text Add to dashboard Cite

show abstract

“…Regarding the polymeric solution characteristics of the solution, the conductivity and viscosity can influence the nanofibrous diameter and the diameter distribution in a considerable manner. Therefore, the high-conductivity polymeric solution will form nanofibers characterized by a wide size distribution, and at the same time the extremely low conductivity solutions combined with moderately high electrical will lead to the formation of inhomogeneous nanofibers [ 51 ]. Also related to the characteristics of the polymer solution for electrospinning, the concentration of the polymer and implicitly the viscosity of the obtained solution represent key factors in the stretching of the charged jet.…”

Section: Electrospun Nanofibers In Wound Healingmentioning

confidence: 99%

An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

et al. 2020

View full text Add to dashboard Cite

Currently, despite the thoroughgoing scientific research carried out in the area of wound healing management, the treatment of skin injuries, regardless of etiology remains a big provocation for health care professionals. An optimal wound dressing should be nontoxic, non-adherent, non-allergenic, should also maintain a humid medium at the wound interfacing, and be easily removed without trauma. For the development of functional and bioactive dressings, they must meet different conditions such as: The ability to remove excess exudates, to allow gaseous interchange, to behave as a barrier to microbes and to external physical or chemical aggressions, and at the same time to have the capacity of promoting the process of healing by stimulating other intricate processes such as differentiation, cell adhesion, and proliferation. Over the past several years, various types of wound dressings including hydrogels, hydrocolloids, films, foams, sponges, and micro/nanofibers have been formulated, and among them, the electrospun nanofibrous mats received an increased interest from researchers due to the numerous advantages and their intrinsic properties. The drug-embedded nanofibers are the potential candidates for wound dressing application by virtue of: Superior surface area-to volume ratio, enormous porosity (can allow oxy-permeability) or reticular nano-porosity (can inhibit the microorganisms’adhesion), structural similitude to the skin extracellular matrix, and progressive electrospinning methodology, which promotes a prolonged drug release. The reason that we chose to review the formulation of electrospun nanofibers based on polysaccharides as dressings useful in wound healing was based on the ever-growing research in this field, research that highlighted many advantages of the nanofibrillary network, but also a marked versatility in terms of numerous active substances that can be incorporated for rapid and infection-free tissue regeneration. In this review, we have extensively discussed the recent advancements performed on electrospun nanofibers (eNFs) formulation methodology as wound dressings, and we focused as well on the entrapment of different active biomolecules that have been incorporated on polysaccharides-based nanofibers, highlighting those bioagents capable of improving the healing process. In addition, in vivo tests performed to support their increased efficacy were also listed, and the advantages of the polysaccharide nanofiber-based wound dressings compared to the traditional ones were emphasized.

show abstract

“…Meanwhile, electrospinning technology has evolved to be effective and has been well studied to produce synthetic or natural biomaterials—modified nano‐ and microfiber structures (100‐2000 nm) with controlled morphology and appropriate performance . Electrospun nanofibers have been demonstrated to be entirely useful in promising biomedical applications, for instance, in the repair and regeneration of tissue/organ, therapeutics biofactor delivery systems and inert biocompatible/biodegradable medical scaffolds as well as in medical diagnostic instrumentation . Electrospun scaffolds with nano‐ or microfibers with internal connected pores, similar to the natural extracellular matrix (ECM) of tissues, indicate a high potential for the amplification of engineered functional tissues.…”

Section: Introductionmentioning

confidence: 99%

Wound healing improvement by curcumin‐loaded electrospun nanofibers and BFP‐MSCs as a bioactive dressing

Golchin

Hosseinzadeh

Jouybar

et al. 2020

Polymers for Advanced Techs

View full text Add to dashboard Cite

Wound healing, one of the most complex processes of the body involving the cooperation of several important biomolecules and pathways, is one of the major therapeutic and economic issues in regenerative medicine. The present study aimed to introduce a novel electrospun curcumin (Cur)-incorporated chitosan/polyvinyl alcohol/carbopol/polycaprolactone nanofibrous composite for concurrent delivery of the buccal fat pad-derived mesenchymal stem cells (BFP-MSCs) and Cur to a fullthickness wound on the mouse model. Scaffolds were characterized structurally using scanning electron microscopy (SEM), fluorescence microscopy imaging and Fouriertransform infrared spectroscopy, and toxicity of the scaffolds was also evaluated after BFP-MSC seeding by SEM imaging and 3-(4,5 dimethyiazol-2-1)-2-5-diphenyl tetrazolium bromide (MTT) assay. Then, its influence on the wound-healing process was investigated as a wound dressing for a full-thickness skin defect in mouse model.Results demonstrated that the designed composite scaffolds have the capability for cell seeding and support their growth and proliferation. Macroscopic and histopathological characteristics were evaluated at the end of the 7 and 14 days after surgery, and their results showed that our designed scaffold groups accelerated the woundhealing process compared with the control group. Among those, scaffold/Cur, scaffold/Cur/BFP-MSC and scaffold/BFP-MSC groups demonstrated more wound repair efficacy. These results indicated that the combined grafts can be used to improve the wound-healing process, and therefore, the electrospun nanofibers presented in this study, Cur and BFP-MSC together, were demonstrated to have promising potential for wound-dressing applications. K E Y W O R D S chitosan/polyvinyl alcohol/carbopol/polycaprolactone, curcumin, electrospun nanofibers, mesenchymal stem cells, regenerative medicine, wound healing

show abstract

Electrospun nanofibers as a wound dressing for treating diabetic foot ulcer

Cited by 174 publications

References 124 publications

The Management of Diabetic Foot Ulcers Using the Wound Treatment Techniques of Modern Dressing: A Systematic Review

The Management of Diabetic Foot Ulcers Using the Wound Treatment Techniques of Modern Dressing: A Systematic Review

An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

Wound healing improvement by curcumin‐loaded electrospun nanofibers and BFP‐MSCs as a bioactive dressing

Contact Info

Product

Resources

About