Electrospun Nanofibrous Membranes for Preventing Tendon Adhesion

Alimohammadi, Mahdieh; Aghli, Yasaman; Fakhraei, Omid; Moradi, Ali; Passandideh-Fard, Mohammad; Ebrahimzadeh, Mohammad H.; Khademhosseini, Ali; Tamayol, Ali; Shaegh, Seyed Ali Mousavi

doi:10.1021/acsbiomaterials.0c00201

Cited by 31 publications

(18 citation statements)

References 92 publications

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“…Fibrous scaffolds offer anisotropic mechanical and architectural properties, which mimics those observed in some native tissues such as tendons, ligaments, and muscles [ 56 , 57 ]. These scaffolds can be fabricated using several different techniques such as random, organized stacking of fibers, or assembly using textile processes.…”

Section: Biofabrication Of Natural Hydrogel-based Scaffoldsmentioning

confidence: 99%

Biofabrication of natural hydrogels for cardiac, neural, and bone Tissue engineering Applications

Elkhoury

Morsink²,

Sánchez-González³

et al. 2021

Bioactive Materials

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111

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Natural hydrogels are one of the most promising biomaterials for tissue engineering applications, due to their biocompatibility, biodegradability, and extracellular matrix mimicking ability. To surpass the limitations of conventional fabrication techniques and to recapitulate the complex architecture of native tissue structure, natural hydrogels are being constructed using novel biofabrication strategies, such as textile techniques and three-dimensional bioprinting. These innovative techniques play an enormous role in the development of advanced scaffolds for various tissue engineering applications. The progress, advantages, and shortcomings of the emerging biofabrication techniques are highlighted in this review. Additionally, the novel applications of biofabricated natural hydrogels in cardiac, neural, and bone tissue engineering are discussed as well.

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Section: Biofabrication Of Natural Hydrogel-based Scaffoldsmentioning

confidence: 99%

Biofabrication of natural hydrogels for cardiac, neural, and bone Tissue engineering Applications

Elkhoury

Morsink²,

Sánchez-González³

et al. 2021

Bioactive Materials

Self Cite

111

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“…[ 142 ] Alginate based nanofiber membrane was developed to prevent postsurgical tendon‐sheath adhesions. [ 152 ] Guardix‐SG is a thermosensitive antiadhesive consisting of alginate, CaCl 2 , and poloxamer, forming gel at body temperature and providing a physical barrier for up to 21 days. Alginate was used by Ito et al.…”

Section: Biomaterials To Fabricate Antiadhesion Barriersmentioning

confidence: 99%

Advancement of Biomaterial‐Based Postoperative Adhesion Barriers

Chandel

Shimizu

Hasegawa

et al. 2021

Macromolecular Bioscience

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Postoperative peritoneal adhesion (PPA) is a prevalent incidence that generally happens during the healing process of traumatized tissues. It causes multiple severe complications such as intestinal obstruction, chronic abdominal pain, and female infertility. To prevent PPA, several antiadhesion materials and drug delivery systems composed of biomaterials are used clinically, and clinical antiadhesive is one of the important applications nowadays. In addition to several commercially available materials, like film, spray, injectable hydrogel, powder, or solution type have been energetically studied based on natural and synthetic biomaterials such as alginate, hyaluronan, cellulose, starch, chondroitin sulfate, polyethylene glycol, polylactic acid, etc. Moreover, many kinds of animal adhesion models, such as cecum abrasion models and unitary horn models, are developed to evaluate new materials’ efficacy. A new animal adhesion model based on hepatectomy and conventional animal adhesion models is recently developed and a new adhesion barrier by this new model is also developed. In summary, many kinds of materials and animal models are studied; thus, it is quite important to overview this field's current progress. Here, PPA is reviewed in terms of the species of biomaterials and animal models and several problems to be solved to develop better antiadhesion materials in the future are discussed.

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“…[ 29 ] It should act as a tissue growth support and vehicle for the cells and growth factors, while the adhesion of surrounded tissue should be avoided. [ 66 ] The scaffold is also supposed to recapitulate the mechanical features of the healthy tissue, guaranteeing the transmission of forces and strengthening the joint, without risk of failure. [ 2 ] In order to design a proper scaffold for tendon and ligament engineering, various natural materials, biodegradable polymers, and composite biomaterials have been considered.…”

Section: Tendon and Ligament Tissue Engineeringmentioning

confidence: 99%

“…Additionally, electrospun nanofibers have been successfully applied as tendon biomimetic sheath or physical barrier, to prevent adhesion of surrounded tissues. [ 66 ] The local release of bioactive agents loaded into the membranes can further improve the antiadhesion effect and enhance tendon repair, as deeply described by Alimohammadi et al.…”

Section: Fiber‐based Engineered Scaffolds For Tendons and Ligamentsmentioning

confidence: 99%

Fibrous Systems as Potential Solutions for Tendon and Ligament Repair, Healing, and Regeneration

Rinoldi

Kijeńska‐Gawrońska

Khademhosseini

et al. 2021

Adv Healthcare Materials

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Tendon and ligament injuries caused by trauma and degenerative diseases are frequent and affect diverse groups of the population. Such injuries reduce musculoskeletal performance, limit joint mobility, and lower people's comfort. Currently, various treatment strategies and surgical procedures are used to heal, repair, and restore the native tissue function. However, these strategies are inadequate and, in some cases, fail to re‐establish the lost functionality. Tissue engineering and regenerative medicine approaches aim to overcome these disadvantages by stimulating the regeneration and formation of neotissues. Design and fabrication of artificial scaffolds with tailored mechanical properties are crucial for restoring the mechanical function of tendons. In this review, the tendon and ligament structure, their physiology, and performance are presented. On the other hand, the requirements are focused for the development of an effective reconstruction device. The most common fiber‐based scaffolding systems are also described for tendon and ligament tissue regeneration like strand fibers, woven, knitted, braided, and braid‐twisted fibrous structures, as well as electrospun and wet‐spun constructs, discussing critically the advantages and limitations of their utilization. Finally, the potential of multilayered systems as the most effective candidates for tendon and ligaments tissue engineering is pointed out.

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Electrospun Nanofibrous Membranes for Preventing Tendon Adhesion

Cited by 31 publications

References 92 publications

Biofabrication of natural hydrogels for cardiac, neural, and bone Tissue engineering Applications

Biofabrication of natural hydrogels for cardiac, neural, and bone Tissue engineering Applications

Advancement of Biomaterial‐Based Postoperative Adhesion Barriers

Fibrous Systems as Potential Solutions for Tendon and Ligament Repair, Healing, and Regeneration

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