Electrospun PCL Patches with Controlled Fiber Morphology and Mechanical Performance for Skin Moisturization via Long-Term Release of Hemp Oil for Atopic Dermatitis

Abstract

Atopic dermatitis (AD) is a chronic, inflammatory skin condition, caused by wide genetic, environmental, or immunologic factors. AD is very common in children but can occur at any age. The lack of long-term treatments forces the development of new strategies for skin regeneration. Polycaprolactone (PCL) is a well-developed, tissue-compatible biomaterial showing also good mechanical properties. In our study, we designed the electrospun PCL patches with controlled architecture and topography for long-term release in time. Hemp oil shows anti-inflammatory and antibacterial properties, increasing also the skin moisture without clogging the pores. It can be used as an alternative cure for patients that do not respond to traditional treatments. In the study, we tested the mechanical properties of PCL fibers, and the hemp oil spreading together with the release in time measured on skin model and human skin. The PCL membranes are suitable material as patches or bandages, characterized by good mechanical properties and high permeability. Importantly, PCL patches showed release of hemp oil up to 55% within 6 h, increasing also the skin moisture up to 25%. Our results confirmed that electrospun PCL patches are great material as oil carriers indicating a high potential to be used as skin patches for AD skin treatment.

Cannabis-Based Products for the Treatment of Skin Inflammatory Diseases: A Timely Review

“…Furthermore, no patients experienced any adverse reaction to either oil during the treatment period. Recently, a polycaprolactone (PCL) patch was developed with the aim to study the long-term release of hemp seed oil on a skin model and on the skin of three human volunteers [79]. The results showed up to 55% of oil release within 6 h, while the moisturization of the volunteers' skin increased around 25%.…”

Enhanced mechanical performance and wettability of PHBV fiber blends with evening primrose oil for skin patches improving hydration and comfort

“…The different shapes of the curves as a result of the uniaxial stretching of electrospun fibers can be caused by the chemical composition of the polymer solution as well as the physical strengthening of the fibers. 24,40,56,57 Overall, PHB is a brittle material with low toughness. The increased flexibility was achieved by copolymerizing the PHB homopolymer with the HV monomer.…”

“…[20][21][22] Direct blending biocompatible polymers with natural oils to enhance the oil delivery for skin moisturization effects helps in maintaining the problematic skin, for example with eczema. 23,24 Poly(3-hydroxybutyrate-co-3hydroxyvalerate) is widely used as a biomaterial due to its high a Faculty of Metals Engineering and Industrial Computer Science, AGH University of Science and Technology, Cracow, Poland. E-mail: ustachew@agh.edu.pl b Academic Centre for Materials and Nanotechnology, AGH University of Science and Technology, Cracow, Poland † Electronic supplementary information (ESI) available.…”

Topical Use of Cannabis sativa L. Biochemicals

“…Moreover, Hemp Seed Oil is a non-comedogenic [137] dry oil that does not leave a greasy and sticky layer on the skin [137]. As a result, formulations have been developed with Hemp Seed Oil as long-term moisturizing patches [138] and stable emulsions in sunscreen cosmetics [5,136]. Hemp Seed Oil's global antioxidant activity can be measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,20-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) test [130].…”