Electrospun PLA/MWCNTs composite nanofibers for combined chemo- and photothermal therapy

Electrospun pH-sensitive core–shell polymer nanocomposites fabricated using a tri-axial process

“…However, it can 389 easily result in an anaphylactic reaction, and to an allergic reaction in the digestive 390 tract [52,53]. With traditional electrospun nanofibers, the drug is released by diffusion 391 through an insoluble polymeric matrix, or by an erosion mechanism from a 392 water-soluble carrier (or a combination of both processes) [39,43]. Here the drug 393 release from the core-shell composites is expected to include two successive steps 394 (Fig.…”

“…These include not only 126 core-shell fibers [34,35], but also fibers prepared from materials without 127 filament-forming properties [36] and used as templates for creating nanotubes (from 128 the fiber as a whole) or the "bottom-up" generation of NPs (self-assembled from the 129 components loaded in the fibers) [26,37]. For biomedical applications, core-shell 130 nanofibers proffer a series of new possibilities; for instance, it is possible to protect a 131 fragile active ingredient such as a protein from the stresses of the electrospinning 132 processes by confining it to the core, or to vary the APIs concentration in the core and 133 shell to achieve complex drug release profiles [38][39][40][41]. In the traditional coaxial 134 process the sheath working fluid must be electrospinnable, but a modified process in 135 which one can utilize unspinnable liquids as the sheath fluid is also possible.…”

Photosensitizer effects of MWCNTs-COOH particles on CT26 fibroblastic cells exposed to laser irradiation

“…MWCNTs are capable of converting NIR radiation to heat and also, they are biocompatible. Studies have shown that MWCNTs can reduce adverse side effects to healthy tissues, leading to increased anticancer effects [22,23].…”

Paclitaxel‐Loaded Polylactide/Polyethylene Glycol Fibers with Long‐Term Antitumor Activity as a Potential Drug Carrier for Local Chemotherapy

“…Intravenous administration of a current formulation in a nonaqueous solvent, Cremophor EL, may cause precipitation in an aqueous dilution or allergic reactions . To overcome the limitations associated with poor water solubility and to achieve prolonged drug activity, more “sophisticated” delivery systems are being developed, e.g., systems with nanoscale additives, such as mesoporous silica nanoparticles, carbon nanotubes, or hydroxyapatite nanoparticles incorporated into electrospun nanofibrous carriers. The release of hydrophobic drugs can also be favorably influenced by increasing the surface area of the carrier by forming a micro‐/nanoparticle delivery system or by the addition of leachable polymers, such as PEGs .…”