Electrospun PLGA Membranes with Incorporated Moxifloxacin-Loaded Silica-Based Mesoporous Nanocarriers for Periodontal Regeneration

Pouroutzidou, Georgia Κ.; Lazaridou, Maria; Papoulia, Chrysanthi; Tsamesidis, Ioannis; Chrissafis, K.; Vourlias, G.; Paraskevopoulos, K. M.; Bikiaris, Dimitrios N.; Kontonasaki, Eleana

doi:10.3390/nano12050850

Cited by 18 publications

(13 citation statements)

References 101 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another study constructed nanocomposite membranes that could deliver moxifloxacin by incorporating MSNs particles into PLGA fibers. The drug release is significantly prolonged because the drug needs to be released from the MSNs to the PLGA fibers first and then diffused from the fibers into the medium [ 78 ].…”

Section: Nanomaterials Applied In Periodontal Tissue Engineeringmentioning

confidence: 99%

Nanomaterials in Scaffolds for Periodontal Tissue Engineering: Frontiers and Prospects

Chen

Huang

2022

Bioengineering

View full text Add to dashboard Cite

The regeneration of periodontium represents important challenges to controlling infection and achieving functional regeneration. It has been recognized that tissue engineering plays a vital role in the treatment of periodontal defects, profiting from scaffolds that create the right microenvironment and deliver signaling molecules. Attributable to the excellent physicochemical and antibacterial properties, nanomaterials show great potential in stimulating tissue regeneration in tissue engineering. This article reviewed the up-to-date development of nanomaterials in scaffolds for periodontal tissue engineering. The paper also represented the merits and defects of different materials, among which the biocompatibility, antibacterial properties, and regeneration ability were discussed in detail. To optimize the project of choosing materials and furthermore lay the foundation for constructing a series of periodontal tissue engineering scaffolds, various nanomaterials and their applications in periodontal regeneration were introduced.

show abstract

Section: Nanomaterials Applied In Periodontal Tissue Engineeringmentioning

confidence: 99%

Nanomaterials in Scaffolds for Periodontal Tissue Engineering: Frontiers and Prospects

Chen

Huang

2022

Bioengineering

View full text Add to dashboard Cite

show abstract

“…Electrospinning is a prevalent technology for top-down production of nanofibers, which utilizes high-voltage electrostatics to draw working fluids into filaments ( Rezaei et al, 2022 ; Yin et al, 2022 ; Basar et al, 2023 ; Boaretti et al, 2023 ; Zhou et al, 2023 ). During the electrospinning process, drugs or other nanoparticles can be effortlessly loaded into nanofibers without altering their original properties ( Yin et al, 2021 ; Izgis et al, 2022 ; Pouroutzidou et al, 2022 ; Figueroa-Lopez et al, 2023 ). Traditional electrospun nanofibers with a single layer usually result in an initial burst of release.…”

Section: Introductionmentioning

confidence: 99%

Electrospun core–sheath PCL nanofibers loaded with nHA and simvastatin and their potential bone regeneration applications

Qian

Liu

Chen

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Introduction: Drugs and biocompatible nanoparticles have raised significant potential in advancing the bone regeneration. Electrospinning technology enables the full realization of the value of drugs and nanoparticles.Methods: In this study, we have successfully fabricated core–sheath nanofibers solely composed of polycaprolactone (PCL) polymer. Simvastatin (SIM) was confined to the core of the nanofibers while nanohydroxyapatite (nHA) was loaded on the nanofiber surface.Results: All the prepared nanofibers exhibited a cylindrical micromorphology, and the core–sheath structure was exploited using a Transmission Electron Microscope. X-ray pattern results indicated that SIM was in an amorphous state within nanofibers, while Fourier Transform InfraRed spectroscopy showed excellent chemical compatibility among SIM, nHA, and PCL. The actual loading of nHA within the nanofiber was determined by a thermogravimetric test due to the high melting point of nHA. Core–sheath nanofibers could release SIM for 672 h, which was attributed to the core–sheath structure. Furthermore, nanofibers loaded with SIM or nHA had a positive impact on cell proliferation, with the core–sheath nanofibers displaying the most favorable cell proliferation behavior.Discussion: Such a synergistic facilitation strategy based on materials and nanostructure may encourage researchers to exploit new biomedical materials in future.

show abstract

“…At the nanoscale, structural changes can easily lead to improvements in the macroscopic performance. Electrospinning technology is a bottom-up electrohydrodynamic process characterized by high voltages and low currents . Based on its rapid fiber fabrication process, the intricate structures can form in a single route without the need for post-treatment.…”

Section: Introductionmentioning

confidence: 99%

Electrospun Core–Sheath Nanofibers with a Cellulose Acetate Coating for the Synergistic Release of Zinc Ion and Drugs

Chen,

Liu,

Liu

2023

Mol. Pharmaceutics

View full text Add to dashboard Cite

Precisely modulating the synergistic release behavior of multiple bioactive substances has emerged as a formidable challenge in recent years. In this work, we successfully prepared core−sheath nanofibers, where a thin cellulose acetate (CA) coating enrobed the core. Curcumin (Cur) was encapsulated in the core layer as a model drug, while zinc oxide (ZnO) nanoparticles were loaded on the sheath layer. The prepared fiber exhibited a straight cylindrical morphology containing nanoparticles, and the distinct core−sheath nanostructure was demonstrated through transmission electron microscopy (TEM). X-ray diffraction (XRD) and Fourier transform infrared (FTIR) were conducted to study the physical state and compatibility among CA, Cur, and ZnO. Drug release data indicated that core−sheath nanofibers were able to decelerate the rate of drug release, and the thickness of the sheath layer increased in the presence of ZnO particles. Most remarkably, these core−sheath nanofibers exhibited the remarkable ability to sustain the release of drugs and zinc ion (Zn 2+ ), the two-day synergistically release behavior leading to a significant increase in cell proliferation. This material preparation strategy for the synergistic and controlled release of two bioactive substances is instructive for the exploration of innovative and versatile drug delivery systems.

show abstract

Electrospun PLGA Membranes with Incorporated Moxifloxacin-Loaded Silica-Based Mesoporous Nanocarriers for Periodontal Regeneration

Cited by 18 publications

References 101 publications

Nanomaterials in Scaffolds for Periodontal Tissue Engineering: Frontiers and Prospects

Nanomaterials in Scaffolds for Periodontal Tissue Engineering: Frontiers and Prospects

Electrospun core–sheath PCL nanofibers loaded with nHA and simvastatin and their potential bone regeneration applications

Electrospun Core–Sheath Nanofibers with a Cellulose Acetate Coating for the Synergistic Release of Zinc Ion and Drugs

Contact Info

Product

Resources

About