Electrospun PLGA/SF/artemisinin composite nanofibrous membranes for wound dressing

“…Similarly, chrysin and grape seed extracts, which reduce oxidative stress, have been experimentally applied as wound dressings when loaded in polycaprolactone/polyethylene glycol or silk fibroin/polyethylene glycol, respectively ( Lin et al, 2016 ; Deldar et al, 2018 ). Additionally, through regulations of pro-inflammatory cytokines, such as IL-1β and TNF-α, the artemisinin originally derived from the sweet wormwood ( Artemisia annua ), was incorporated into poly (lactic-co-glycolic acid)/silk fibroin and showed a shortened inflammatory cycle with enhanced skin regeneration in a rat model of dorsal full-thickness wounds ( Peng et al, 2021 ). Likewise, by a direct effect on macrophages, ginsenoside Rg1 integrated into a novel asymmetric wettable electrospun membrane displayed a promoted macrophage polarization towards M2 phenotype, therefore facilitated a better infected wound healing compared to commercial Aquacel Ag dressings ( Zhou et al, 2022 ).…”

Section: Electrospinning Of Botanicals For Skin Wound Healingmentioning

confidence: 99%

Electrospinning of botanicals for skin wound healing

Guo

Wang

Song

et al. 2022

Front. Bioeng. Biotechnol.

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Being the first barrier between the human body and external environments, our skin is highly vulnerable to injuries. As one of the conventional therapies, botanicals prepared in different topical formulations have been applied as medical care for centuries. With the current increase of clinical requirements, applications of botanicals are heading towards nanotechnologies, typically fused with electrospinning that forms nanofibrous membranes suitable for skin wound healing. In this review, we first introduced the main process of wound healing, and then presented botanicals integrated into electrospun matrices as either loaded drugs, or carriers, or membrane coatings. In addition, by addressing functional features of individual botanicals in the healing of injured skin, we further discussed the bioactivity of botanical electrospun membranes in relevant to the medical issues solved in the process of wound healing. As achieved by pioneer studies, due to infrequent adverse effects and the diversity in resources of natural plants, the development of electrospun products based on botanicals is gaining greater attention. However, investigations in this field have mainly focused on different methodologies used in the preparation of nanofibrous membranes containing botanicals, their translation into clinical practices remains unaddressed. Accordingly, we propose that potential clinical applications of botanical electrospun membranes require not only the further expansion and understanding of botanicals, but also an establishment of standard criteria for the evaluation of wound healing and evolutions of technologies to support the large-scale manufacturing industry.

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“…Therefore, the development of new medical dressings has gradually become more popular. Various wound dressings have been studied, such as rubber [ 10 , 11 , 12 ], polyionic liquid membrane [ 13 , 14 ], electrostatically spun nanofibers [ 15 , 16 , 17 ], and hydrogel [ 18 ]. Among these dressings, a hydrogel is the material that best meets people’s requirements for ideal dressings [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Progress in Antibacterial Hydrogel Dressing

Liu

Jiang

et al. 2022

Gels

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Antibacterial hydrogel has excellent antibacterial property and good biocompatibility, water absorption and water retention, swelling, high oxygen permeability, etc.; therefore, it widely applied in biomedicine, intelligent textiles, cosmetics, and other fields, especially for medical dressing. As a wound dressing, the antibacterial hydrogel has the characteristics of absorbing wound liquid, controlling drug release, being non-toxic, being without side effects, and not causing secondary injury to the wound. Its preparation method is simple, and can crosslink via covalent or non-covalent bond, such as γ-radiation croFsslinking, free radical polymerization, graft copolymerization, etc. The raw materials are easy to obtain; usually these include chondroitin sulfate, sodium alginate, polyvinyl alcohol, etc., with different raw materials being used for different antibacterial modes. According to the hydrogel matrix and antibacterial mode, the preparation method, performance, antibacterial mechanism, and classification of antibacterial hydrogels are summarized in this paper, and the future development direction of the antibacterial hydrogel as wound dressing is proposed.

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Electrospun PLGA/SF/artemisinin composite nanofibrous membranes for wound dressing

Cited by 61 publications

References 53 publications

Preparation and characterization of a novel drug-loaded Bi-layer scaffold for cartilage regeneration

Preparation and characterization of a novel drug-loaded Bi-layer scaffold for cartilage regeneration

Electrospinning of botanicals for skin wound healing

Progress in Antibacterial Hydrogel Dressing

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