2014
DOI: 10.1371/journal.pone.0090676
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Electrospun Poly(ester-Urethane)- and Poly(ester-Urethane-Urea) Fleeces as Promising Tissue Engineering Scaffolds for Adipose-Derived Stem Cells

Abstract: An irreversible loss of subcutaneous adipose tissue in patients after tumor removal or deep dermal burns makes soft tissue engineering one of the most important challenges in biomedical research. The ideal scaffold for adipose tissue engineering has yet not been identified though biodegradable polymers gained an increasing interest during the last years. In the present study we synthesized two novel biodegradable polymers, poly(ε-caprolactone-co-urethane-co-urea) (PEUU) and poly[(L-lactide-co-ε-caprolactone)-c… Show more

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Cited by 23 publications
(18 citation statements)
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“…In particular, one important aspect is the correct design of non-woven fleeces that mimic the collagen parallel structure and the biomechanics of the native ECM of the tendon [8,9]. Electrospinning has been identified as a valuable manufacturing process to generate constructs mimicking the micro and submicron-scaled fibrous structure of the native ECM of various soft tissues [10][11][12][13]. Using an advantageous electrospinning technique, this process can be also used to fabricate fleeces mimicking the highly aligned collagen fibrils of native tendons and ligaments [14][15][16][17][18].…”
Section: Introductionmentioning
confidence: 99%
“…In particular, one important aspect is the correct design of non-woven fleeces that mimic the collagen parallel structure and the biomechanics of the native ECM of the tendon [8,9]. Electrospinning has been identified as a valuable manufacturing process to generate constructs mimicking the micro and submicron-scaled fibrous structure of the native ECM of various soft tissues [10][11][12][13]. Using an advantageous electrospinning technique, this process can be also used to fabricate fleeces mimicking the highly aligned collagen fibrils of native tendons and ligaments [14][15][16][17][18].…”
Section: Introductionmentioning
confidence: 99%
“…In such cases, the tubule thickness and inner lumen diameter should be designed to meet the requirements of the host tissue. The skin or other similar tissue reconstruction strategies demand flat sheet scaffolds [9] , [10] . Here also, the thickness should be carefully controlled to avoid the development of any necrotic cores.…”
Section: Introductionmentioning
confidence: 99%
“…One of the most popular types of polymers is poly(alpha-hydroxy esters), which come in a variety of forms and are aliphatic. 10 Poly(lactic acid) (PLA) is a biological product made up of lactic acid monomers, which are naturally produced in the human body in metabolic pathways and then broken down. 11 PLA as a most widely used polymer in medical applications, which consists of three isomeric forms: poly(L-lactic acid) (PLLA), poly(D-lactic acid) (PDLA), and poly(D,L-lactic acid) (PDLLA).…”
mentioning
confidence: 99%