Electrospun polyacrylonitrile nanofibrous biomaterials

Abstract

An N-halamine precursor, 3-(5'-methyl-5'-hydantoinyl)acetanilide (I), was synthesized in our laboratory and loaded onto electrospun polyacrylonitrile fiber to prepare nanosized biocidal materials, which could be rendered antimicrobial by exposure to household bleach. Differential scanning calorimetry was used to study the thermal properties of the nanofibers with and without the N-halamine precursor and its chlorinated derivative loaded. Scanning electron microscopy demonstrated that the ultrafine fibers formed with diameters from 250 to 600 nm. Chlorinated nanofibrous mats composed of the fibers were challenged with Staphylococcus aureus (ATCC 6538) and Escherichia coli O157:H7 (ATCC 43895); they showed promising inactivation efficacies against the two bacterial species within 5 minutes of contact. Potential uses of the antimicrobial fibers include filters for industrial water and air disinfection and protective clothing.

Preparation and characterization of antimicrobial electrospun poly(vinyl alcohol) nanofibers containing benzyl triethylammonium chloride

“…Two types of polymers have been used for the synthesis of antimicrobial nanofibers. The first is related to solvent-soluble polymers such as polyamide [5,6], polyacrylonitrile [7][8][9][10][11], polyurethane [12], poly(methyl methacrylate) [13], poly(vinylidene) fluoride [14], polycarbonate [15,16], poly(vinyl phenol) [17], and cellulose acetate [18]. The second includes water-soluble polymers such as polyethylene oxide [19,20], poly(acrylic acid) [21,22], poly(vinylpyrrolidone) [14,23] and poly(vinyl alcohol) (PVA) [24][25][26][27][28][29].…”

Development of cytocompatible antibacterial electro-spun nanofibrous composites

“…Recently, researchers have focused on preparing antimicrobial fibers containing N-halamine compounds by electro-spinning techniques [17][18][19][20][21][22][23][24]. Unlike conventional fiber spinning techniques (wet spinning, dry spinning, melt spinning, and gel spinning) which are capable of producing polymer fibers with diameters down to the micrometer range, electro-spinning is a process capable of producing polymer fibers in nanometer size with many unique properties, such as smaller pores and higher surface area than regular fibers [25].…”

Electrospun non-leaching biocombatible antimicrobial cellulose acetate nanofibrous mats

“…Recently, researchers have been focused on preparing antimicrobial fibers containing N-halamines using electrospun techniques [32][33][34]. After chlorination, the nanofibers showed excellent antimicrobial properties.…”