Electrospun polyurethane fiber mats coated with fish collagen layer to improve cellular affinity for skin repair

Sofi, Hasham S.; Abdal‐hay, Abdalla; Rashid, Rumaisa; Rafiq, Asma; Rather, Sami‐ullah; Beigh, Mushtaq A.; Alrokayan, Salman H.; Khan, Haseeb A.; Tripathi, Ravi Mani; Sheikh, Faheem A.

doi:10.1016/j.susmat.2022.e00523

Cited by 5 publications

(4 citation statements)

References 66 publications

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“…Subsequently, the fiber samples were removed from the hydrothermal reactor and dried at 40°C in a hot air dryer (Rivotek, Mumbai, India, TSH 379) for 48 h. Since PU is thermoplastic and its soft segment can melt at 90°C; therefore, the hydrothermal reaction temperature was set at 80°C. Our group has already established that reaction conditions above this temperature will change the form of the PU nanofibers and cause the fibers to coalesce, resulting in the loss of porosity 30 . At the end of the hydrothermal process, four types of samples were obtained viz, PU, PU + M1% coated with Ag NPs1% and chitosan10% as PU + M:A(1%) + C10%, PU + M3% coated with Ag NPs3% and chitosan15% as PU + M:A(3%) + C15%, and PU + M5% coated with Ag NPs5% and chitosan20% as PU + M: A(5%) + C20%.…”

Section: Methodsmentioning

confidence: 99%

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Polyurethane nanofibers incorporated magnesium hydroxide followed by hydrothermal treatment using chitosan and silver nanoparticles to improve the biological properties

Rather,

Khan,

Rafiq

et al. 2024

J of Applied Polymer Sci

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The study aimed to explore the potential of magnesium hydroxide (Mg[OH]₂) nanoparticles (NPs) incorporated into polyurethane (PU) fibers, which were further coated with chitosan and silver (Ag) NPs. The hydrothermal approach was adopted to add the properties of chitosan and Ag NPs to the as‐spun fibers. These samples were characterized by field emission scanning electron microscope (FE‐SEM), EDS, Fourier transform infrared spectroscopy, thermogravimetric analysis, and contact angle measurements. The diameter of concocted fibers was found to be 0.79 ± 0.31 μm to 2.5 ± 0.9 μm. The presence of Mg(OH)2 decreased the fiber diameter from 2.05 ± 1.2 μm to 0.79 ± 0.31 μm; however, after hydrothermal coating, the diameter increased from 0.79 ± 0.31 μm to 2.5 ± 0.9 μm. The contact angle on pristine PU showed 105.53 ± 0.8°, that is, hydrophobicity, which was diminished to 9.3 ± 0.8° by the reorientation of PU with Mg(OH)2, chitosan and Ag NPs, that is, indicative of hydrophilic character. Biomineralization was evaluated by incubating in simulated body fluid, and the EDS and FE‐SEM indicated that composite fibers could induce apatite formation. Cell viability was measured using MTT assay, and cell adhesion/proliferation was confirmed by DAPI staining and FE‐SEM. The composite scaffolds promoted 3T3‐L1 to grow confluently.

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Section: Methodsmentioning

confidence: 99%

“…Our group has coated the as‐spun PU nanofiber with collagen extracted from fish scales using the hydrothermal technique 30 . The study strongly suggests that in situ hydrothermal treatment of electrospun nanofibers can change the hydrophobicity and improve the mechanical properties desired for applications in wound dressing.…”

Section: Introductionmentioning

confidence: 99%

Polyurethane nanofibers incorporated magnesium hydroxide followed by hydrothermal treatment using chitosan and silver nanoparticles to improve the biological properties

Rather,

Khan,

Rafiq

et al. 2024

J of Applied Polymer Sci

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“…Chronic wounds, as an epidemic disease with significant morbidity, affect more than 1% of people, and have become a major challenge in the medical care system. [1][2][3] Diabetic wounds are typical chronic wounds that affect many diabetic patients due to their difficult healing and high recurrence rate. [4,5] Although novel therapies for diabetic wound treatment involving biochemical (e.g., growth factors) and biophysical therapies (e.g., negative pressure therapy and hyperbaric oxygen therapy) have been developed, the therapeutic effect of chronic wound treatment is still unsatisfactory.…”

Section: Introductionmentioning

confidence: 99%

Chlorella‐Loaded Antibacterial Microneedles for Microacupuncture Oxygen Therapy of Diabetic Bacterial Infected Wounds

Gao,

Rao,

Wang

et al. 2024

Advanced Materials

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Hypoxia and infection are urgent clinical problems in chronic diabetic wounds. Herein, living Chlorella‐loaded poly(ionic liquid)‐based microneedles (PILMN‐Chl) were constructed for microacupuncture oxygen and antibacterial therapy against methicillin‐resistant Staphylococcus aureus (MRSA)‐infected chronic diabetic wounds. The PILMN‐Chl can stably and continuously produce oxygen for more than 30 h due to the photosynthesis of the loaded self‐supported Chlorella. By combining the barrier penetration capabilities of microneedles, the continuous and sufficient oxygen supply of Chlorella and the sterilization activities of PIL, the PILMN‐Chl can accelerate chronic diabetic wounds in vivo by topical targeted sterilization and hypoxia relief in deep parts of wounds. Thus, the self‐oxygen produced microneedles modality may provide a promising and facile therapeutic strategy for treating chronic, hypoxic, and infected diabetic wounds.This article is protected by copyright. All rights reserved

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“…Their goal is to evaluate the effect of naproxen loading as well as the thicknesses of the membrane on in vitro release, demonstrating that as the thickness increases, the total released drug decreases, allowing for extending the release time up to 120 h [23]. In some other previous works, other kinds of thermoplastic polyurethane (TPU)-based medical devices were produced [24][25][26][27]. The impregnation process assisted by supercritical carbon dioxide (scCO 2 ) allows overcoming these obstacles thanks to the possibility of having, at the same time, high diffusivity, near-zero surface tension, high density, and high solvent power.…”

Section: Introductionmentioning

confidence: 99%

Supercritical Impregnation of Mesoglycan and Lactoferrin on Polyurethane Electrospun Fibers for Wound Healing Applications

Mottola

Viscusi

Iannone

et al. 2023

IJMS

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Fibrous membranes of thermoplastic polyurethane (TPU) were fabricated through a uni-axial electrospinning process. Fibers were then separately charged with two pharmacological agents, mesoglycan (MSG) and lactoferrin (LF), by supercritical CO2 impregnation. Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray Spectroscopy (EDS) analysis proved the formation of a micrometric structure with a homogeneous distribution of mesoglycan and lactoferrin. Besides, the degree of retention is calculated in four liquid media with different pHs. At the same time, angle contact analysis proved the formation of a hydrophobic membrane loaded with MSG and a hydrophilic LF-loaded one. The impregnation kinetics demonstrated a maximum loaded amount equal to 0.18 ± 0.20% and 0.07 ± 0.05% for MSG and LT, respectively. In vitro tests were performed using a Franz diffusion cell to simulate the contact with the human skin. The release of MSG reaches a plateau after about 28 h while LF release leveled off after 15 h. The in vitro compatibility of electrospun membranes has been evaluated on HaCaT and BJ cell lines, as human keratinocytes and fibroblasts, respectively. The reported data proved the potential application of fabricated membranes for wound healing.

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Electrospun polyurethane fiber mats coated with fish collagen layer to improve cellular affinity for skin repair

Cited by 5 publications

References 66 publications

Polyurethane nanofibers incorporated magnesium hydroxide followed by hydrothermal treatment using chitosan and silver nanoparticles to improve the biological properties

Polyurethane nanofibers incorporated magnesium hydroxide followed by hydrothermal treatment using chitosan and silver nanoparticles to improve the biological properties

Chlorella‐Loaded Antibacterial Microneedles for Microacupuncture Oxygen Therapy of Diabetic Bacterial Infected Wounds

Supercritical Impregnation of Mesoglycan and Lactoferrin on Polyurethane Electrospun Fibers for Wound Healing Applications

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