Electrospun polyurethane membranes for Tissue Engineering applications

Tamborlin

J of Applied Polymer Sci

et al. 2019

Self Cite

Polymeric membranes have gained popularity as fibrous structures for tissue regeneration. This research focuses on the rotary jet spinning (RJS) process combined with a polymer as a strategy for designing membranes. To this end, RJS‐polyurethane (RJS‐PU) membranes with different microstructures were produced. Considering the effects of solution properties on fiber production, the viscosity of PU solutions was evaluated. Membrane morphology was studied based on scanning electron microscopy and 2D fast Fourier transform analysis. The chemical and thermal properties were characterized by Fourier‐transform infrared spectroscopy and thermogravimetric analysis, respectively. 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide and Live/Dead cell assays were performed to determine the material cytotoxicity by assessment of the profile of proliferation and cell viability. The results indicated that the combination of PU and RJS was an effective one for the production of fibrous structures for tissue engineering applications, demonstrating good compatibility with the cultured osteoblastic cell line. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48455.

Section: Resultsmentioning

confidence: 95%

Polyurethane fibrous membranes tailored by rotary jet spinning for tissue engineering applications

Tamborlin

J of Applied Polymer Sci

et al. 2019

Self Cite

“…The peaks at 1221 cm −1 was corresponded to the stretching vibration of the C-N bonds. The bands at 1163 cm −1 and 1068 cm −1 represented the stretching vibration of the C-O-C groups [38,39]. In addition, there were no characteristic peaks at 1687 cm −1 and 1071 cm −1 which demonstrated that there were no residues of DMF and THF in the PU electrospun nanofibrous membrane.…”

Section: Chemical Characterization and Wettability Of As-prepared Memmentioning

confidence: 94%

Novel Janus Fibrous Membranes with Enhanced Directional Water Vapor Transmission

Tang

Zhang

et al. 2019

Applied Sciences

Novel hydrophobic/hydrophilic Janus fibrous membranes, the poly[4,4 -methylenebis (phenylisocyanate)-alt-1,4-butanediol/di(propylene glycol)/plycaprolactone] (PU) fibrous membrane as the hydrophobic layer and cellulose acetate (CA) fibrous membrane as the hydrophilic layer, were fabricated by the so-called "layer-by-layer" electrospinning technology. A series of the PU/CA Janus membranes with different electrospinning time of the CA layers by which the thickness of hydrophilic layer can be controlled were also prepared to uncover its influence on the directional water vapor transmission. The results showed that water vapor transmission capability from the hydrophobic side to the hydrophilic side of the PU/CA Janus fibrous membrane was enhanced rather than that from the reverse direction of the same membrane. The optimal water vapor transmission capacity existed when the electrospinning time of CA fibrous membrane reached 15 min. Such enhanced water vapor transmission originated because of the asymmetric wettability of the Janus membrane and the strong force to draw tiny water droplet from the hydrophobic side to the hydrophilic side. The novel understanding is useful for facile designing and fabrication of efficient moisture permeable fabrics and clothing.

“…PLA can exist as either the D-, L-lactide enantiomers, or a mixture of both (PLDA), of which L-lactide is popular in TE applications due to its slow degradation rate [ 30 ]. Moreover, further polymers—such as polyether ether ketone (PEEK) [ 31 ], polyimide [ 32 ], and polyurethanes [ 33 , 34 ]—have been used as successful scaffolding materials for the repair of a variety of tissues. Naturally occurring biomaterials—for instance, collagen [ 35 , 36 , 37 ], chitosan (CHT) [ 38 , 39 ], alginate [ 40 , 41 ], fibrinogen [ 42 , 43 ], and gelatin [ 44 , 45 ]—have also seen recent work as the main components of scaffolds, proving to enhance cell adhesion due to the recognition features they exhibit.…”

Section: Introductionmentioning

confidence: 99%

Polyelectrolyte Multilayer Capsule (PEMC)-Based Scaffolds for Tissue Engineering

et al. 2020

Tissue engineering (TE) is a highly multidisciplinary field that focuses on novel regenerative treatments and seeks to tackle problems relating to tissue growth both in vitro and in vivo. These issues currently involve the replacement and regeneration of defective tissues, as well as drug testing and other related bioapplications. The key approach in TE is to employ artificial structures (scaffolds) to support tissue development; these constructs should be capable of hosting, protecting and releasing bioactives that guide cellular behaviour. A straightforward approach to integrating bioactives into the scaffolds is discussed utilising polyelectrolyte multilayer capsules (PEMCs). Herein, this review illustrates the recent progress in the use of CaCO3 vaterite-templated PEMCs for the fabrication of functional scaffolds for TE applications, including bone TE as one of the main targets of PEMCs. Approaches for PEMC integration into scaffolds is addressed, taking into account the formulation, advantages, and disadvantages of such PEMCs, together with future perspectives of such architectures.