Electrospun polyvinyl alcohol-chitosan dressing stimulates infected diabetic wound healing with combined reactive oxygen species scavenging and antibacterial abilities

Recent advances of hydrogels as smart dressings for diabetic wounds

“…Diabetic wounds undergo sustained inflammation, which leads to oxidative stress (imbalance between oxidative and antioxidant components in the body), as evidenced by elevated levels of reactive oxygen species (ROS). 29 ROS are a collective term for several oxygen(O 2 )-derived chemical derivatives from mitochondrial, peroxisomal, and approximately 40 enzyme systems, including superoxide anions, hydrogen peroxide (H 2 O 2 ), and hydroxyl radicals. 30 Under normal circumstances, ROS are an effective means for the body to defend against pathogens, and their levels are low.…”

Hydrogel-based dressings designed to facilitate wound healing

“…240,254 In the presence of an exacerbated infection, macrophages produce higher levels of ROS to combat the invading pathogens. 255–257 Excessive production of ROS leads to the generation of various pro-inflammatory cytokines, disruption of ECM, and oxidative damage. These factors prolong the existence of M1 macrophages and impede their polarization process towards M2 macrophages.…”

Innovative approaches in skin therapy: bionanocomposites for skin tissue repair and regeneration

“…7(D)). 109 Liu et al, 164 prepared mupirocin (MP) and/or cerium oxide NPs (CeNPs) incorporated PVA/CS nanofiber membrane wound dressing using electrostatic spinning (Fig. 8).…”

“…Moreover, PVA-CS-CeNPs-MP demonstrated greater skin regeneration and neovascularization, as seen in Masson's trichrome staining. 164 Electrospun scaffolds were prepared using PVA, gelatin, and ZnO NPs (0%, 0.5%, and 1%). The addition of 1 wt% ZnO to PVA/gelatin hydrogel slightly increased the water contact angle from 48.8741 to 66.2821, but it remained hydrophilic (WCA o 901).…”