Electrospun Scaffolds of Biodegradable Polyesters: Manufacturing and Biomedical Application

Pranke, Patrícia; Weibel, Daniel Eduardo; Braghirolli, Daikelly Iglesias

doi:10.1002/9783527656950.ch7

Cited by 1 publication

(1 citation statement)

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“…The electrospinning technique allows for the development of three-dimensional scaffolds based on fibers constructed from different polymers, making it possible to control the diameter of the fibers and the porosity of the material ( 1 , 35 ). The equipment of electrospinning consists of a syringe with a needle attached to its tip connected to an electrode, a hydrostatic pump and an electrical source ( 36 ) ( Figure 3A ). In the syringe, a polymer solution is conditioned and through the hydrostatic pump, it is directed to a collecting plate.…”

Section: Vte Techniquesmentioning

confidence: 99%

Vascular Tissue Engineering: Polymers and Methodologies for Small Caliber Vascular Grafts

Leal

Wakabayashi

Oyama

et al. 2021

Front. Cardiovasc. Med.

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127

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Cardiovascular disease is the most common cause of death in the world. In severe cases, replacement or revascularization using vascular grafts are the treatment options. While several synthetic vascular grafts are clinically used with common approval for medium to large-caliber vessels, autologous vascular grafts are the only options clinically approved for small-caliber revascularizations. Autologous grafts have, however, some limitations in quantity and quality, and cause an invasiveness to patients when harvested. Therefore, the development of small-caliber synthetic vascular grafts (<5 mm) has been urged. Since small-caliber synthetic grafts made from the same materials as middle and large-caliber grafts have poor patency rates due to thrombus formation and intimal hyperplasia within the graft, newly innovative methodologies with vascular tissue engineering such as electrospinning, decellularization, lyophilization, and 3D printing, and novel polymers have been developed. This review article represents topics on the methodologies used in the development of scaffold-based vascular grafts and the polymers used in vitro and in vivo.

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Section: Vte Techniquesmentioning

confidence: 99%