Since the zero-net-mass-flux (ZNMF) jet was first used as a laboratory flow control method in 1990's, it has attracted much attention. The ZNMF jet has unique features such as compact actuator, no requirement for external air supply, complex piping, etc., and becomes a hot topic research subject in fluid mechanics. This review introduces the state of the art in the development of ZNMF jet in the quiescent fluid, the interaction of the ZNMF jet with the cross flow and its application in the separation flow control. The evolution of the vortex ring/pair and the spacial flow structure of the ZNMF in quicent fluid or cross flow are presented, as well as the key parameter effects. At last, the applications of ZNMF jet in the wake control of the circular cylinder, the separation control on the airfoil and the aerodynamic force or moment control on MAV/UAV are presented. zero-net-mass-flux jet, quiescent fluid, cross flow, separation control