Electrosynthesis of pyrrole 3-carboxylic acid copolymer films and nanotubes with tunable degree of functionalization for biomedical applications

Roy, Cécile; Leprince, Lucas; Boulard, Arnaud De; Landoulsi, Jessem; Callegari, Vincent; Jonas, Alain M.; Demoustier‐Champagne, Sophie

doi:10.1016/j.electacta.2010.10.076

Cited by 12 publications

(14 citation statements)

References 43 publications

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“…CPs, which have functional groups have received great attention due to their ability to form strong covalent bonds with biologically active molecules and create highly stable biodetection system. Recently poly‐N‐alkylpyrroles , poly (pyrrole‐3‐carboxylic acid) and poly (pyrrole‐2‐carboxylic acid) (PCPy) have been electrochemically polymerized. The synthesis of carboxylic acid‐functionalized polypyrrole‐silica microparticles by copolymerizing pyrrole‐3‐acetic acid with pyrrole using a hydrogen peroxide‐based oxidant in the presence of an ultrafine silica sol was also recently proposed by McCarthy and Armes .…”

Section: Introductionmentioning

confidence: 62%

An Amperometric Glucose Biosensor Based on Poly (Pyrrole‐2‐Carboxylic Acid)/Glucose Oxidase Biocomposite

Kausaitė-Minkstimienė

Glumbokaitė

Ramanavičienė

et al. 2018

Electroanalysis

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A newly developed amperometric glucose biosensor based on graphite rod (GR) working electrode modified with biocomposite consisting of poly (pyrrole‐2‐carboxylic acid) (PCPy) particles and enzyme glucose oxidase (GOx) was investigated. The PCPy particles were synthesized by chemical oxidative polymerization technique using H2O2 as initiator of polymerization reaction and modified covalently with the GOx (PCPy‐GOx) after activation of carboxyl groups located on the particles surface with a mixture of N‐(3‐dimethylaminopropyl)‐N′‐ethylcarbodiimide hydrochloride (EDC) and N‐hydroxysuccinimide (NHS). Then the PCPy‐GOx biocomposite was dispersed in a buffer solution containing a certain amount of bovine serum albumin (BSA). The resulting biocomposite suspension was adsorbed the on GR electrode surface with subsequent solvent airing and chemical cross‐linking of the proteins with glutaraldehyde vapour (GR/PCPy‐GOx). It was determined that the current response of the GR/PCPy‐GOx electrodes to glucose measured at +300 mV vs Cl reference electrode was influenced by the duration of the PCPy particles synthesis, pH of the GOx solution used for the PCPy particles modification and the amount of immobilized PCPy‐GOx biocomposite. An optimal pH of buffer solution for operation of the biosensor was found to be 8.0. Detection limit was determined as 0.039 mmol L−1 according signal to noise ratio (S/N: 3). The proposed glucose biosensor was tested in human serum samples.

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Section: Introductionmentioning

confidence: 62%

An Amperometric Glucose Biosensor Based on Poly (Pyrrole‐2‐Carboxylic Acid)/Glucose Oxidase Biocomposite

Kausaitė-Minkstimienė

Glumbokaitė

Ramanavičienė

et al. 2018

Electroanalysis

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“…Although N-substituted polypyrrole has been employed for sensor applications, there are few studies on the preparation of these polymers in the nanowire morphology. Moreover, these studies have utilised either a template approach or coated already grown polypyrrole nanowires with the functionalised polypyrrole [14,15]. Here, we present results for the synthesis of novel PPyEtCN nanowires, and to the best of our knowledge this is the first report of a one-step preparation of N-substituted polypyrrole nanowires using a facile template-free electrochemical approach.…”

Section: Introductionmentioning

confidence: 74%

Facile template-free electrochemical preparation of poly[N-(2-cyanoethyl)pyrrole] nanowires

McCarthy

McGuinness

Alcock-Earley

et al. 2012

Electrochemistry Communications

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a b s t r a c t a r t i c l e i n f oIn this paper the first synthesis of poly[N-(2-cyanoethyl)pyrrole] (PPyEtCN) in a nanowire morphology is reported. The method employed is a facile, one step electrochemical growth, which does not require the use of any templates or surfactants. Using optimised conditions the nanowires nucleate to give a homogeneous film across the electrode surface, with lengths of approximately 2 μm and diameters of approximately 150 nm. Structural information on the nanowires was obtained using vibrational spectroscopy. Evidence is presented to support an instantaneous 3-D nucleation and growth mechanism for the nanowires.

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“…Among many conductive polymers, polypyrrole has attracted great attention since its efficient preparation in aquoeus media, good electrical conductivity, robosity, and biocompability. [ 24,25 ] Polypyrrole‐3‐carboyxlic acid was chosen in the study in order to bring functionality to polypyrrole modified surfaces.…”

Section: Resultsmentioning

confidence: 99%

Fabrication of self‐functionalized polymeric surfaces and their application in electrochemical acetaminophen detection

Kuralay

Çağlayan

Ilhan

et al. 2020

J of Applied Polymer Sci

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Conducting polymer coatings have offered functionalized surfaces having good electrical, mechanical, and physical properties. In this work, electrochemical preparation and characterization of polypyrrole/polypyrrole‐3‐carboxylic acid (PPy/PPa) copolymer onto single‐use pencil graphite electrodes (PGEs) were described and detailed. Then, the application of these electrodes was demonstrated for the detection a commonly used analgesic, acetaminophen (AC) (paracetamol). Copolymer was deposited onto PGEs using cyclic voltammetry (CV) between +0.0 V and +1.0 V versus Ag/AgCl. Experimental conditions such as the effect of monomer ratios (3:1–6:1) and cyclic scans (1 cycle to 10 cycles) on electropolymerization were examined. Coated surfaces were characterized with CV and scanning electron microscopy. Electrochemical response of the electrode in AC at various pH values was evaluated. Then, AC detection was performed based on the oxidation signal of the drug at about +0.55 V versus Ag/AgCl using differential pulse voltammetry in buffer and body fluid (serum).

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Electrosynthesis of pyrrole 3-carboxylic acid copolymer films and nanotubes with tunable degree of functionalization for biomedical applications

Cited by 12 publications

References 43 publications

An Amperometric Glucose Biosensor Based on Poly (Pyrrole‐2‐Carboxylic Acid)/Glucose Oxidase Biocomposite

An Amperometric Glucose Biosensor Based on Poly (Pyrrole‐2‐Carboxylic Acid)/Glucose Oxidase Biocomposite

Facile template-free electrochemical preparation of poly[N-(2-cyanoethyl)pyrrole] nanowires

Fabrication of self‐functionalized polymeric surfaces and their application in electrochemical acetaminophen detection

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