Elemene, One Ingredient of a Chinese Herb, Against Malignant Tumors: A Literature-based Meta-analysis

Xu, Hongbin; Zheng, Longpo; Li, Ling; Xu, Lichao; Fu, Jun

doi:10.3109/07357907.2012.756108

Cited by 20 publications

(6 citation statements)

References 12 publications

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“…Elemene has been shown to suppress signaling such as MAPK and PI3K/Akt/mTOR pathway involved in proliferation, induce cell death, up-regulate growth suppressors, deactivate invasion and metastasis, and attenuate angiogenesis (reviewed in [226]). Large variations in the quality and size of clinical trials reduces the reliability of the interpretation of the results, but a meta-analysis of 38 clinical trials showed an overall positive effect of elemene in combination with chemotherapy in lung cancer, hepatocarcinoma, metastatic brain cancer, and leukemia, but not in gastric carcinoma [235]. Another meta-analysis identified elemene injection as a safe and effective adjunctive treatment to platinum-based chemotherapy in patients with stage III/IV non-small cell lung cancer, where it showed enhanced efficacy and cellular immune function, as well as reduced the toxicity of chemotherapy.…”

Section: Elemenementioning

confidence: 99%

Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis

Tomko

Whynot

Ellis

et al. 2020

Cancers

160

139

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In recent years, and even more since its legalization in several jurisdictions, cannabis and the endocannabinoid system have received an increasing amount of interest related to their potential exploitation in clinical settings. Cannabinoids have been suggested and shown to be effective in the treatment of various conditions. In cancer, the endocannabinoid system is altered in numerous types of tumours and can relate to cancer prognosis and disease outcome. Additionally, cannabinoids display anticancer effects in several models by suppressing the proliferation, migration and/or invasion of cancer cells, as well as tumour angiogenesis. However, the therapeutic use of cannabinoids is currently limited to the treatment of symptoms and pain associated with chemotherapy, while their potential use as cytotoxic drugs in chemotherapy still requires validation in patients. Along with cannabinoids, cannabis contains several other compounds that have also been shown to exert anti-tumorigenic actions. The potential anti-cancer effects of cannabinoids, terpenes and flavonoids, present in cannabis, are explored in this literature review.

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Section: Elemenementioning

confidence: 99%

Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis

Tomko

Whynot

Ellis

et al. 2020

Cancers

160

139

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show abstract

“…Increasing attention has been paid to uncovering the anti-tumor potential and mechanisms of Chinese herbal medicine. Chinese herbs have been found to inhibit cell proliferation, angiogenesis and tumor metastasis, induce cell apoptosis and differentiation and regulate tumor-associated signaling pathways and the immune system ( 5 – 7 ), thus exhibiting anti-tumor potential in vitro and in vivo .…”

Section: Introductionmentioning

confidence: 99%

Effects of maslinic acid on the proliferation and apoptosis of A549 lung cancer cells

Bai

Zhang

Jiang

et al. 2015

Molecular Medicine Reports

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Maslinic acid (MA) is a pentacyclic triterpene acid that is present in numerous dietary plants. Although certain studies have demonstrated that MA has anti-cancer properties in different cell types, the effect of MA on lung cancer cell proliferation and apoptosis and the potential underlying mechanisms remain to be elucidated. In the present study, A549 lung cancer cells were treated with different doses of MA and it was found that MA significantly inhibited A549 cell growth in a dose-dependent manner. In addition, Annexin V/propidium iodide flow cytometric analysis demonstrated that MA induced apoptosis of A549 cells. The present study also confirmed that MA induced apoptosis by observing morphological alterations. In addition, the effect of MA treatment on the levels of apoptosis-associated proteins was examined. The results demonstrated that MA treatment suppressed the expression of caspase-3, -8 and -9, and increased the expression of cleaved caspase-3, -8 and -9 in a dose-dependent manner. The level of inhibitors of apoptosis (IAPs) and Smac, which are possible upstream factors of caspase proteins, were also examined. It was found that MA treatment increased the protein expression of Smac and decreased the protein levels of c-IAP1, c-IAP2, X-linked inhibitor of apoptosis protein (XIAP) and Survivin in a dose-dependent manner. These results suggested that MA inhibited proliferation and induced apoptosis of A549 cells through regulation of caspase cleavage as well as Smac, c-IAP1, c-IAP2, XIAP and Survivin.

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“…In China, it has been used as a therapeutic candidate for certain malignant tumors for several years (20). However, little is known about the underlying molecules.…”

Section: Discussionmentioning

confidence: 99%

“…Other studies found that β-elemene could enhance tumor chemosensitivity or overcome drug resistance (17,18). In addition, β-elemene has been approved by the China Food and Drug Administration as a therapeutic drug in clinical practice where its efficacy has been exhibited when combined with first-line chemotherapy for malignant tumors (19,20). However, the mechanisms by which β-elemene is involved in tumor suppressing activities remain largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Anticancer effects of β-elemene in gastric cancer cells and its potential underlying proteins: A proteomic study

Liu

Zhang

et al. 2014

Oncology Reports

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Abstract. Gastric cancer is a common malignancy with a poor prognosis. β-elemene is a broad-spectrum anticancer drug extracted from the traditional Chinese medicinal herb Curcuma wenyujin. In the present study, we investigated the anticancer effects of β-elemene in gastric cancer cells and the potential proteins involved. Human SGC7901 and MKN45 gastric cancer cells were treated with different concentrations of β-elemene. Cell viability, clonogenic survival and apoptotic cell death were assessed. β-elemene inhibited viability and decreased clonogenic survival of gastric cancer cells in a dose-dependent manner. Apoptosis induction contributed to the anticancer effects. We then employed a proteomic method, isobaric tags for relative and absolute quantitation (iTRAQ), to detect the proteins altered by β-elemene. In total, 147 upregulated proteins and 86 downregulated proteins were identified in response to β-elemene treatment in SGC7901 gastric cancer cells. Among them, expression of p21-activated protein kinase-interacting protein 1 (PAK1IP1), Bcl-2-associated transcription factor 1 (BTF) and topoisomerase 2-α (TOPIIα) were validated by western blot analyses and the trends were consistent with iTRAQ results. Top pathways involved in β-elemene treatment in SGC7901 gastric cancer cells included ribosome signaling, peroxisome proliferator-activated receptors (PPARs) signaling pathway, regulation of actin cytoskeleton, phagosome, biosynthesis and metabolism of some amino acids. Collectively, our results suggest a promising therapeutic role of β-elemene in gastric cancer. The differentially expressed proteins provide further insight into the potential mechanisms involved in gastric cancer treatment using β-elemene.

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Elemene, One Ingredient of a Chinese Herb, Against Malignant Tumors: A Literature-based Meta-analysis

Cited by 20 publications

References 12 publications

Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis

Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis

Effects of maslinic acid on the proliferation and apoptosis of A549 lung cancer cells

Anticancer effects of β-elemene in gastric cancer cells and its potential underlying proteins: A proteomic study

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