Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: Comparison with selenomethionine in mice

Wang, Huali; Zhang, Jinsong; Yu, Han‐Qing

doi:10.1016/j.freeradbiomed.2007.02.013

Cited by 650 publications

(477 citation statements)

References 57 publications

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“…Based on the LC 50 values (Figure 5), nano-Se b was 3.2-fold less toxic than selenite and 10-fold less toxic than nano-Se c . This result is in contrast to Zhang et al (2001Zhang et al ( , 2005 and Wang et al (2007), where it was reported that chemogenic nano-Se had 7-fold and 3.5-fold lower acute toxicity than sodium selenite and L-selenomethionine, respectively, in Kunming mice. However, Li et al (2008) reported that chemogenic nano-Se particles were more toxic than selenite in medaka fish.…”

Section: Discussioncontrasting

confidence: 75%

A comparison of fate and toxicity of selenite, biogenically, and chemically synthesized selenium nanoparticles to zebrafish (Danio rerio) embryogenesis

et al. 2017

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Section: Discussioncontrasting

confidence: 75%

A comparison of fate and toxicity of selenite, biogenically, and chemically synthesized selenium nanoparticles to zebrafish (Danio rerio) embryogenesis

et al. 2017

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“…Positive effects of chemically synthesized selenium nanospheres were examined in several experiments succesfully. Wang [13] was led to the conclusion in 2007 based on animal tests, nano selenium (Nano-Se) is a very effective antioxidant, without high toxicity properties which is typical for other selenium forms. Nano selenium has at least the same effect on activating glutathione peroxidase and thioredoxin reductase enzymes as selenoproteines has, but acording to the LD 50 this form is less toxical, it doesn't trigger acute liver injury and short term toxications.…”

Section: Nano-sized Elemental Seleniummentioning

confidence: 99%

Elemental, Nano-Sized (100-500 nm) Selenium Production by Probiotic Lactic Acid Bacteria

Eszenyi¹,

Sztrik²,

Babka³

et al. 2011

IJBBB

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Abstract-Selenium is well known as an essential trace element since the 20th century, but it can be overdosed easily because of its toxicity. According to the present regulations [1] only the potentially most harmful, inorganic selenium salts can be added to any comestibles. Elemental selenium is considered as the least toxical of all selenium forms and in the same time supplementation with its nano-size particles has the same or better bioavailability compared to its salts. In our experiments we managed to produce nano-size (100-500nm) elemental selenium by using probiotic yogurt bacteria in a fermentation procedure. We developed the laboratory technology of product purification and recovery from bacteria.

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“…When the FDA first permitted the usage of Se yeast in poultry diets in 2001, Se yeast products have been developed and reported to be more effective than inorganic Se used in chicken feeds (Rayman 2004;Ševčíková et al 2006;Yoon et al 2007). Nano red elemental Se was a new Se source, which has novel characteristics such as a large surface area, high surface activity, high catalytic efficiency, strong adsorbing ability and low toxicity (Zhang et al 2001;Peng et al 2007;Wang et al 2007). Mennini (2012) reported that Nano-Se and selenite could similarly increase tissue Se and glutathione peroxidases in Se-deficient rats, which indicated that the bioavailability of the two Se forms was similar.…”

Section: Introductionmentioning

confidence: 99%

Effect of selenium sources on growth performance and tissue selenium retention in yellow broiler chicks

Liu

Tan

Shi

et al. 2014

Journal of Applied Animal Research

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An experiment was conducted to investigate the effects of selenium (Se) sources on growth performance and tissue Se retention in yellow chicks fed a conventional corn-soybean meal basal diet. A total of 2250 one-day-old chicks were fed a Se-unsupplemented corn-soybean meal basal diet (containing 0.10 mg of Se/kg) for six days, and then chicks were assigned by body weight to 1 of 5 treatments with 6 replicates of 75 birds each floor pen in a completely randomized design. Broilers were fed the basal diet (control) or basal diet supplemented with 0.3 mg/kg of Se from sodium selenite, Nano elemental Se, Se yeast A or B for 10 days. The results showed that Se sources did not significantly (P > 0.52) affect growth performance. Se sources significantly affected (P < 0.05) Se concentrations in liver and breast muscle, in which chicks fed the diet supplemented with Se yeast B had higher (P < 0.05) tissue Se concentrations than those fed the diet supplemented with sodium selenite or Nano elemental Se. No differences (P > 0.66) were observed in liver and breast muscle Se concentrations among sodium selenite, Nano elemental Se and Se yeast A. Therefore, the new procedure used in this experiment could detect the differences of the effectiveness among Se sources, and Se yeast B was the most effective Se source for yellow broiler chicks.

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Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: Comparison with selenomethionine in mice

Cited by 650 publications

References 57 publications

A comparison of fate and toxicity of selenite, biogenically, and chemically synthesized selenium nanoparticles to zebrafish (Danio rerio) embryogenesis

A comparison of fate and toxicity of selenite, biogenically, and chemically synthesized selenium nanoparticles to zebrafish (Danio rerio) embryogenesis

Elemental, Nano-Sized (100-500 nm) Selenium Production by Probiotic Lactic Acid Bacteria

Effect of selenium sources on growth performance and tissue selenium retention in yellow broiler chicks

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