Elevated and Absent pRb Expression is Associated With Bladder Cancer Progression and has Cooperative Effects With p53

Corte, R.J.; Dunn, Matthew D.; Chatterjee, Sumana; Stein, John P.; Shi, Shan; Tran, Q.-C.; Hu, Shi‐Xue; Xu, Hong‐Ji; Groshen, Susan; Taylor, Clive R.; Skinner, Donald G.; Benedict, William F.

doi:10.1016/s0022-5347(01)62456-x

Cited by 78 publications

(122 citation statements)

References 10 publications

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“…Chan et al (20) found 31% of SCCs showed loss of retinoblastoma staining. The range of 21-37% also correlates well with findings in other cancers (e.g., 26% in breast carcinoma) (21) , 27% in lung carcinoma (16) , and 29% in bladder carcinoma (22) . Tumorigenesis is known to be a multistep process, and in some cancers the normal tumor suppressor role of pRb is altered by overexpression of cyclin D1, direct loss of pRb function, or by other methods that can override the inhibitory effect of this tumor suppressor gene, such as binding of the E7 oncoprotein of HPV.…”

Section: Cyclin D1 and Prb Expression In Vulvar Cancersupporting

confidence: 82%

Cyclin D1 and retinoblastoma protein in vulvar cancer and adjacent lesions

Rolfe,

Crow,

Benjamin

et al. 2001

Int J Gynecol Cancer

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Abnormalities in the cell cycle are associated with tumorigenesis but have not yet been identified in squamous cell carcinoma (SCC) of the vulva or in adjacent vulvar lesions. The purpose of this study was to identify cell cycle protein expression (cyclin D1 and retinoblastoma protein [pRb]) in vulvar SCC and in adjacent potentially premalignant lesions: lichen sclerosis (LS), squamous cell hyperplasia (SH), and vulvar intraepithelial neoplasia (VIN). Using immunohistochemical techniques, 57 SCCs were analyzed with 19 adjacent areas showing LS, 13 showing SH, 11 VIN, and six normal epithelium. Fifty-one percent of SCCs showed abnormal cyclin D1 expression and 37% showed abnormal pRb. Abnormal cyclin D1 expression in the adjacent areas was as follows: 53% in LS, 31% in SH, 18% in VIN, and 0% in normal. Abnormal pRb expression was as follows: 42% in LS, 62% in SH, 46% in VIN, and 33% in normal. Only 10 lesions showed abnormal expression of both proteins. Abnormal expression of cyclin D1 in SCC was statistically significant compared with adjacent normal epithelium. In SCC lesions, abnormal cyclin D1 expression was associated with greater depth of invasion. Abnormal pRb in SCC was associated with poor tumor grade. Cyclin D1 and pRb are separately involved in the progression of vulvar cancer, and changes in the expression of these proteins may represent an early stage of malignant transformation in vulvar disease.

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Section: Cyclin D1 and Prb Expression In Vulvar Cancersupporting

confidence: 82%

Cyclin D1 and retinoblastoma protein in vulvar cancer and adjacent lesions

Rolfe,

Crow,

Benjamin

et al. 2001

Int J Gynecol Cancer

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“…64 Among these are the cell cycle related genes Rb, p53, p21/waf1, and p16. [65][66][67][68] Tumour suppressor gene therapy is well suited for intravesical administration. Gene correcting and tumour vaccination studies have been shown to be effective in animals, in particular by increasing the sensitivity of bladder cancer cells to chemotherapeutic agents.…”

Section: Laser Treatmentmentioning

confidence: 99%

Changes produced in the urothelium by traditional and newer therapeutic procedures for bladder cancer

López-Beltrán

2002

Journal of Clinical Pathology

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“…Lowered expression of Rb was, for example, inversely related to poor prognosis of bladder tumors (23,24) . Curiously, elevated Rb expression was also associated with cancer progression and poor prognosis in bladder cancer (24) . Similarly our present study revealed that patients intensively expressing Rb showed poorest prognosis ( Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Molecules downstream of p53 have also been implicated in cancer prognosis: expression of p21 WAF(1)/ CIP(1) and p14 ARF was associated with cell proliferation in ovarian cancer (19) ; overexpression of MDM2 with advancement of the disease has been found in prostate cancers (20) and in head and neck cancers (21) ; allelic loss at the Rb locus has been found in various cancers; and Rb status has been implicated in prognosis of bladder tumors (22)(23)(24) .…”

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confidence: 99%

Independence of the prognostic value of tumor suppressor protein expression in ovarian adenocarcinomas: A multivariate analysis of expression of p53, retinoblastoma, and related proteins

Tachibana

Watanabe

Matsushima

et al. 2003

International Journal of Gynecological Cancer

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Accurate estimation of prognosis of ovarian cancer is difficult. For this report, in a group of 73 patients with ovarian adenocarcinomas, clinical factors and protein expression status of p53, retinoblastoma (Rb), and related proteins were evaluated for potential prognostic values. Clinical factors included FIGO stage, age, histopathologic type, and protein expression of p53, Rb, MDM2, p14ARF, p21WAF(1)/CIP(1) was determined by an immunohistochemical technique. Univariate Cox proportional hazard regression analysis was used to determine the significant prognostic value of FIGO stage (P < 0.0001), p53 status (0.0021), and patient age (P = 0.0255), and we report here, for the first time, the significant (P = 0.0072) prognostic value of Rb status. Histopathologic type and MDM2, p14ARF, p21WAF(1)/CIP(1) status did not show any prognostic value. To examine further the independence of prognostic values, we next applied multivariate analysis: We found that FIGO stage (P < 0.0001) and p53 status (P = 0.0108) were independent prognostic factors, while age and Rb status were not. Independence of prognostic value of p53 has heretofore been controversial, but we found a definite independent prognostic value for p53 status in ovarian adenocarcinomas. We also found that selection of appropriate antibodies for immunohistochemistry was essential to obtain significant results. We used five kinds of antibodies for p53 immunolocalization, and correlation with prognosis was obtained by three of these with different grades of statistical significance.

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Elevated and Absent pRb Expression is Associated With Bladder Cancer Progression and has Cooperative Effects With p53

Cited by 78 publications

References 10 publications

Cyclin D1 and retinoblastoma protein in vulvar cancer and adjacent lesions

Cyclin D1 and retinoblastoma protein in vulvar cancer and adjacent lesions

Changes produced in the urothelium by traditional and newer therapeutic procedures for bladder cancer

Independence of the prognostic value of tumor suppressor protein expression in ovarian adenocarcinomas: A multivariate analysis of expression of p53, retinoblastoma, and related proteins

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