Elevated birth defects in racial or ethnic minority children of women living near hazardous waste sites

Orr, Maureen F.; Bove, Frank; Kaye, Wendy; Stone, Melanie

doi:10.1078/1438-4639-00126

Cited by 51 publications

(54 citation statements)

References 13 publications

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“…For example, elevated risks for neural tube defects and heart defects were reported for maternal residence close to hazardous waste sites (Croen et al, 1997;Orr et al, 2002) and landfill sites that handle hazardous chemical wastes (Dolk et al, 2002). There was also a positive association between mothers' consumption of home tap water during the first trimester and cardiac anomalies (Shaw et al, 1990).…”

Section: Introductionmentioning

confidence: 97%

Residential mobility patterns and exposure misclassification in epidemiologic studies of birth defects

Canfield

Ramadhani

Langlois

et al. 2006

J Expo Sci Environ Epidemiol

130

113

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Many studies of environmental exposures and birth defects use mothers' addresses at delivery as a proxy for the exposure. The validity of these studies is questionable because birth defects generally occur within 8 weeks of conception and the mother's address at delivery may differ from her address early in pregnancy. In order to assess the extent of this bias, we examined the pattern of maternal residential mobility over the span of 3 months prior to conception through delivery, and associated maternal socio-demographic characteristics. We linked Texas subjects from a national case-control study of birth defects with their corresponding records from the Texas Birth Defects Registry and the Texas live birth certificates. Logistic regression analyses were conducted to assess maternal socio-demographic factors related to mobility during pregnancy. Overall, 33% of case and 31% of control mothers changed residence between conception and delivery. The pattern of mobility was similar for both case and control mothers for each pregnancy period. Multivariate analyses indicated that for case mothers, older age (OR ¼ 0.39, 95% CI ¼ 0.21-0.70), higher household income (OR ¼ 0.35, 95% CI ¼ 0.18-0.68), Hispanic ethnicity (OR ¼ 0.64, 95% CI ¼ 0.44-0.92), and higher parity (OR ¼ 0.59, 95% CI ¼ 0.38-0.94) were indicators of lower mobility during pregnancy. For control mothers, the same pattern of association was present, however, only older age was significantly associated with low rates of mobility. Studies of birth defects using maternal address at delivery as a proxy for maternal environmental exposures during pregnancy may be subject to considerable nondifferential exposure misclassification due to maternal mobility during pregnancy.

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Section: Introductionmentioning

confidence: 97%

Residential mobility patterns and exposure misclassification in epidemiologic studies of birth defects

Canfield

Ramadhani

Langlois

et al. 2006

J Expo Sci Environ Epidemiol

130

113

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“…Two studies found no associations with cardiac defects. 188,189 Surveillance data from population-based congenital anomaly registers in 16 regions of Europe (mainly Western Europe) were analyzed to evaluate the impact of the Chernobyl accident on the prevalence of selected congenital anomalies. 190 Chernobyl had no detectable impact on the prevalence of congenital anomalies in Western Europe.…”

Section: Other Environmental Concernsmentioning

confidence: 99%

Noninherited Risk Factors and Congenital Cardiovascular Defects: Current Knowledge

Jenkins¹,

Correa²,

Feinstein³

et al. 2007

Circulation

712

336

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Abstract-Prevention of congenital cardiovascular defects has been hampered by a lack of information about modifiable risk factors for abnormalities in cardiac development. Over the past decade, there have been major breakthroughs in the understanding of inherited causes of congenital heart disease, including the identification of specific genetic abnormalities for some types of malformations. Although relatively less information has been available on noninherited modifiable factors that may have an adverse effect on the fetal heart, there is a growing body of epidemiological literature on this topic. This statement summarizes the currently available literature on potential fetal exposures that might alter risk for cardiovascular defects. Information is summarized for periconceptional multivitamin or folic acid intake, which may reduce the risk of cardiac disease in the fetus, and for additional types of potential exposures that may increase the risk, including maternal illnesses, maternal therapeutic and nontherapeutic drug exposures, environmental exposures, and paternal exposures. Information is highlighted regarding definitive risk factors such as maternal rubella; phenylketonuria; pregestational diabetes; exposure to thalidomide, vitamin A cogeners, or retinoids; and indomethacin tocolysis. Caveats regarding interpretation of possible exposure-outcome relationships from case-control studies are given because this type of study has provided most of the available information. Guidelines for prospective parents that could reduce the likelihood that their child will have a major cardiac malformation are given. Issues related to pregnancy monitoring are discussed. Knowledge gaps and future sources of new information on risk factors are described.

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“…PCB exposure has been associated with birth defect occurrence in animal models (Marks et al, 1989;Hatano and Hatano, 1994;Pocar et al, 2005;Kopf and Walker, 2009). Epidemiologic studies, however, have been inconsistent in documenting associations with birth defects in humans and PCB exposure (Croen et al, 1997;Orr et al, 2002;Suarez et al, 2005;Wigle et al, 2008).…”

Section: Discussionmentioning

confidence: 97%

Modeling geographic risk of complex congenital heart defects in Eastern Wisconsin

Cronk¹,

Gangnon²,

Cossette³

et al. 2011

Birth Defects Research Part A: Clinical and Molecular Teratolog

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Elevated birth defects in racial or ethnic minority children of women living near hazardous waste sites

Cited by 51 publications

References 13 publications

Residential mobility patterns and exposure misclassification in epidemiologic studies of birth defects

Residential mobility patterns and exposure misclassification in epidemiologic studies of birth defects

Noninherited Risk Factors and Congenital Cardiovascular Defects: Current Knowledge

Modeling geographic risk of complex congenital heart defects in Eastern Wisconsin

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