Elevated breast cancer mortality in young women (&lt;40 years) compared with older women is attributed to poorer survival in early-stage disease

Gnerlich, Jennifer L.; Deshpande, Ashwini; Jeffe, Donna B.; Sweet, Allison; White, Nick; Margenthaler, Julie A.

doi:10.1016/j.jamcollsurg.2008.06.196

Cited by 15 publications

(14 citation statements)

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“…Moreover, the highest mortality disparity between younger (<40 years) and older women (≥40 years) was present in early stage, rather than later stage of disease. 21,22 In agreement with other regional and global studies, our results revealed that the histological type of cancer and metastases are associated with survival differernces. 19,8,23 In our study, the three-year survival rate for localized tumor was 96.1% and this figure is consistent with another Saudi study as the authors documented that the localized cancer had a clearly better prognosis (Five-year survival rate = 67.5%).…”

supporting

confidence: 92%

Factors affecting survival of women with breast cancer in King Fahad Medical City, Saudi Arabia

Zaid

Nuzhat

Rafiqe

2017

Int J Community Med Public Health

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INTRODUCTIONBreast cancer (BC) is a major health problem in both developed and developing countries. Around the World, nearly 1.7 million new breast cancer cases were diagnosed in 2012 and this figure represented about 12% of all new cancer cases and 25% of all cancers in women. Since 2008, worldwide breast cancer incidence has increased by more than 20% and mortality has increased by 14 %. ABSTRACTBackground: Breast cancer is the most frequently diagnosed cancer among women in 140 of 184 countries worldwide. The association between breast cancer survival and socio-demographic and pathologic factors has been widely studied in the developed countries. But scarce data is available from Saudi Arabia. We aimed to determine the overall observed one year and three years survival rate of female breast cancer patients and to investigate the factors affecting survival rate. Methods: Retrospective data was collected from the cancer center registry at King Fahad Medical City (KFMC) that included all women diagnosed with breast cancer between 1 st January 2011 till 31 st December 2012 and were followed to 31 st December 2015 (cut off point for follow-up). Kaplan-Meier analysis was done to assess overall survival. The factors affecting survival rate such as age, histological type, tumor grade at diagnosis, metastases and treatment options were investigated using log rank test and Cox regression analysis. Results: The overall observed survival probability of the study population at 1, and 3 years was 95%, and 85%, respectively. The 3 year survivals for the younger (≤40 years), 41-50 years and older (50+ years) patients were 83.9%, 90.6% and 80.6% respectively, the differences not reaching statistical significance. There were statistically significant associations between three year survival and histological type of tumour, laterality, metastases and type of treatment by the univariate analysis log rank test. Conclusions: One and three-year survival rate of breast cancer at KFMC was 96% and 85% respectively. Investigating the factors affecting survival rate is one of the most essential means of improving cancer prognosis.

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confidence: 92%

Factors affecting survival of women with breast cancer in King Fahad Medical City, Saudi Arabia

Zaid

Nuzhat

Rafiqe

2017

Int J Community Med Public Health

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“…29 Specifically, it has been reported in previous studies that women aged less than 40 were 44% and 9% more likely to die of stage I (HR = 1.44; 95% CI, 1.27-1.64) and stage II breast cancer (HR = 1.09; 95% CI, 1.03-1.15), respectively. 36,37 Across all histologic subtypes and stages, breast cancer survival rates are comparatively lower for women <40 years of age than for older women.…”

Section: Resultsmentioning

confidence: 99%

Female breast cancer in different age groups: clincopathological features and treatment strategies

Nuzhat

Abouzaid

2017

Int J Community Med Public Health

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INTRODUCTIONFemale breast cancer is a major public health problem throughout the world. It is the most common cancer type among women in developed and developing countries. Moreover, it is the principal cause of death from cancer among women globally. Nearly 55% of the worldwide burden is now experienced in developed countries, but incidence rates are rapidly rising in developing countries as well. 1According to the annual cancer incidence report published by the Saudi cancer registry, there were 1,853 female breast cancer cases for year 2013. Breast cancer ranked the first among females accounting for 29.1% of all newly diagnosed female cancers (6364) in year 2013. ABSTRACT Background:The proportion of breast cancer cases have been alarmingly increasing. In order to investigate the clinical and pathological features of breast cancer arising in all age groups and to provide evidence for therapy based on these features, we intended to conduct this study among three age groups, young (age ≤40), middle aged (>40-50) and elderly patients (>50). Methods: This cross-sectional study obtained data from the cancer center registry at King Fahad Medical City and included all women diagnosed as breast cancer between 1 st January 2011 till 31 st December 2012 and followed until December 2015 (n=155). Results: 25.2% patients were ≤40 years of age, 38.7% were >40-50 years and 36.1% were >50 years. The upper outer quadrant of the breast was most frequently area involved in all the three age groups. Majority of the cases were Invasive Ductal Carcinoma (IDC). 51.3% cases were of grade III in patients ≤40 years, 43.3% cases in the middle age group (>40-50 years) were of grade II and 44.6% patients were of grade III in the elderly group. More T3 tumours were noticed in the younger group and more T2 in the middle age group and greater lymph node involvement N2 in the age group >50 years. The mean survival time for patients' ≤40 was 37.6 months, 39.3 months for cases >40-50 years and 38.3 for patients >50 years old at the end of three years of follow up. At our cancer centre and among all the groups, majority of patients were treated with a combination of surgery, chemotherapy and radiation Conclusions: This study identifies cliniopathological features of breast cancer in all age groups in a tertiary care center, Saudi Arabia. Distant metastasis was more prevalent among younger age group and the middle aged women had the best mean survival time after three years.

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“…In fact, a slightly higher percentage of patients in the older age category were uninsured (3.5%) in comparison with younger patients (2.3%). Previous studies have found that younger patients are more likely to have higher grade tumors and hormone receptor–negative tumors . A lack of routine breast cancer screening may also contribute to a higher stage at diagnosis, and younger women have been reported to be more likely to present with a palpable mass than a positive mammographic finding …”

Section: Discussionmentioning

confidence: 99%

Breast cancer stage variation and survival in association with insurance status and sociodemographic factors in US women 18 to 64 years old

Hsu

Wang

Habif

et al. 2017

Cancer

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Elevated breast cancer mortality in young women (<40 years) compared with older women is attributed to poorer survival in early-stage disease

Cited by 15 publications

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Factors affecting survival of women with breast cancer in King Fahad Medical City, Saudi Arabia

Factors affecting survival of women with breast cancer in King Fahad Medical City, Saudi Arabia

Female breast cancer in different age groups: clincopathological features and treatment strategies

Breast cancer stage variation and survival in association with insurance status and sociodemographic factors in US women 18 to 64 years old

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