Elevated C-reactive protein and self-reported disease activity in systemic lupus erythematosus

Eudy, Amanda M; Vines, Anissa I.; Dooley, Mary Anne; Cooper, GS; Parks, Christine G.

doi:10.1177/0961203314543915

Cited by 21 publications

(11 citation statements)

References 32 publications

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“…Socioeconomic factors have been associated with disease severity, inflammation, and adverse outcomes in SLE ( 14 , 15 ). Although socioeconomic disparities originating from childhood have been described across a variety of chronic inflammatory diseases ( 16 ), the role of childhood socioeconomic status (SES) and related adversities in risk of SLE is not known.…”

Section: Introductionmentioning

confidence: 99%

Early Life Factors Associated with Adult-Onset Systemic Lupus Erythematosus in Women

2016

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BackgroundExposure early in life can influence adult disease and immunity, but the role of early life exposures in risk of systemic lupus erythematosus (SLE) is not established.MethodsWomen in a national cohort (ages 35–74) provided data on perinatal, maternal, and sociodemographic factors, longest residence to age 14, and residential farm history of at least 12 months to age 18. Cases (N = 124) reported SLE diagnosed age 16 years or older with use of disease modifying antirheumatic drugs. Non-cases (N = 50,465) did not report lupus. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by logistic regression adjusting for age and race/ethnicity.ResultsSLE was associated with low birthweight (data on 84 cases and 36,477 non-cases; <2,500 versus 3,000 to <3,500 g OR = 2.2; 95%CI 1.2, 3.9) and preterm birth (57 cases and 22,784 non-cases; ≥1 month early versus full-term OR = 3.4; 95%CI 1.6, 7.4). Considering longest childhood residence to age 14, SLE was associated with more frequent pesticide use (e.g., at least monthly OR = 2.3; 95%CI 1.3, 4.1). SLE was associated with having an early and extended childhood farm residence (i.e., prenatal/maternal farm exposure and longest childhood farm residence OR = 1.8; 95%CI 1.1, 3.0 versus neither). In those with a childhood-only farm residence of 12+ months, agricultural pesticide use was associated with SLE, with the strongest associations for direct personal exposures.ConclusionThe association of SLE with preterm birth is consistent with studies in other populations and with an observed association with low birthweight. The associations of SLE with childhood exposure to residential and agricultural pesticides warrant further study.

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Section: Introductionmentioning

confidence: 99%

Early Life Factors Associated with Adult-Onset Systemic Lupus Erythematosus in Women

2016

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“…As anti-TNF therapy targets one of the central regulators of the inflammatory response, patients can be left vulnerable to infusion reactions, rashes, fever and papilledema [ 10 , 11 ]. Subtle differences in signal processing of the inflammation signaling cascade may exist between different races, causing differences in outcomes and complication tendencies [ 12 ]. Evaluating short-term and long-term adverse events associated with anti-TNF-α mono-therapy may thus provide critical information to optimize treatment both for the general patient population and this subgroup in particular.…”

Section: Introductionmentioning

confidence: 99%

Adverse Events of Anti-Tumor Necrosis Factor α Therapy in Ankylosing Spondylitis

et al. 2015

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ObjectiveThis study aims to investigate the prevalence of short-term and long-term adverse events associated with tumor necrosis factor-α (TNF-α) blocker treatment in Chinese Han patients suffering from ankylosing spondylitis (AS).MethodsThe study included 402 Chinese Han AS patients treated with TNF-α blockers. Baseline data was collected. All patients were monitored for adverse events 2 hours following administration. Long-term treatment was evaluated at 8, 12, 52 and 104 weeks follow-up for 172 patients treated with TNF-α blockers.ResultsShort-term adverse events occurred in 20.15% (81/402), including rash (3.5%; 14/402), pruritus (1.2%; 5/402), nausea (2.2%; 9/402), headache (0.7%; 3/402), skin allergies (4.0%; 16/402), fever (0.5%; 2/402), palpitations (3.0%; 12/402), dyspnea (0.5%; 2/402), chest pain (0.2%; 2/402), abdominal pain (1.0%; 4/402), hypertension (2.2%; 9/402), papilledema (0.5%; 2/402), laryngeal edema (0.2%; 1/402) and premature ventricular contraction (0.2%; 1/402). Long-term adverse events occurred in 59 (34.3%; 59/172) patients, including pneumonia (7.6%; 13/172), urinary tract infections (9.9%; 17/172), otitis media (4.7%; 8/172), tuberculosis (3.5%; 17/172), abscess (1.2%; 2/172), oral candidiasis (0.6%; 1/172), elevation of transaminase (1.7%; 3/172), anemia (1.2%; 2/172), hematuresis (0.6%; 1/172), constipation (2.3%; 4/172), weight loss (0.6%; 1/172), exfoliative dermatitis (0.6%; 1/172). CRP, ESR and disease duration were found to be associated with an increased risk of immediate and long-term adverse events (P<0.05). Long-term treatment with Infliximab was associated with more adverse events than rhTNFR-Fc (P<0.01).ConclusionThis study reports on the prevalence of adverse events in short-term and long-term treatment with TNF-α blocker monotherapy in Chinese Han AS patients. Duration of disease, erythrocyte sedimentation rate, and c-reactive protein serum levels were found to be associated with increased adverse events with anti-TNF-α therapy. Long-term treatment with Infliximab was associated with more adverse events than rhTNFR-Fc.

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“…patients, and may therefore be predictive for disease activity 28 . The prevalence of elevated CRP was 43.6% in our cohort.…”

Section: Eudy Et Al Observed That Elevated Crp Was Associated With Amentioning

confidence: 99%

Clinical and biochemical manifestations of systemic lupus erythematosus at first diagnosis within Chinese patients

Xie

zhang

Wang

et al. 2019

Preprint

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Bankground: The objective of this paper was to describe the first symptoms associated with systemic lupus erythematosus (SLE), including clinical manifestations, laboratory findings, prognoses, differences between men and women at the time of first diagnosis of SLE. Methods : We enrolled 223 patients with initial diagnosis of SLE. Their initial symptoms, demographic, clinical and laboratory data，prognoses and causes of death were analyzed retrospectively. Clinical manifestations and laboratory profiles were compared between male and female patients. Results: Compared with female patients, male patients had an earlier age of onset, a higher incidence of neuropsychiatric involvements, a lower incidence of leukocytopenia , and a higher score of SLE Disease Activity Index (SLEDAI）at diagnosis. Fever and malar rash were most frequent presentations at onset of SLE. The most common clinical manifestation at first diagnosis was fever, followed by arthralgia, malar rash, Raynaud ’ s phenomenon, arthritis. The liver function abnormalities included increased ALT,AST,ALP and γ-GGT.ANA were found in 100% of patients, followed by anti-dsDNA(LIA) in 72.1%, anti-Ro60 in 67.8%, anti-Ro52 in 62.3%, anti-nucleosomes in 55.7%. Conclusions: We identified clinical and serological manifestations of Chinese SLE patients at first diagnosis. Male patients showed a distinctive manifestation including younger age of onset，a higher incidence of CNS manifestations, a higher score of SLEDAI compared to females.

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Elevated C-reactive protein and self-reported disease activity in systemic lupus erythematosus

Cited by 21 publications

References 32 publications

Early Life Factors Associated with Adult-Onset Systemic Lupus Erythematosus in Women

Early Life Factors Associated with Adult-Onset Systemic Lupus Erythematosus in Women

Adverse Events of Anti-Tumor Necrosis Factor α Therapy in Ankylosing Spondylitis

Clinical and biochemical manifestations of systemic lupus erythematosus at first diagnosis within Chinese patients

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