Elevated Circulating Monocytes and Monocyte Activation in Pulmonary Post-Acute Sequelae of Sars-Cov-2 Infection

Park, Juwon; Dean, Logan S.; Jiyarom, Boonyanudh; Gangcuangco, Louie Mar A.; Shah, Parthav; Awamura, Thomas; Ching, Lauren L.; Nerurkar, Vivek R.; Chow, Dominic C.; Igno, Fritzie; Shikuma, Cecilia; Devendra, Gehan

doi:10.2139/ssrn.4287850

Cited by 1 publication

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We show that the percentage of total monocytes is decreased in COVID-19 patients, with significant decreases in intermediate and non-classical monocytes. These results contrast sharply with a previously published study by Park et al that demonstrated increased circulating total monocytes and increased classical and intermediate monocytes 21 . The differences between our study and the previously published study by Park et al may be due to differences in the study populations (primarily Caucasian vs. primarily Asian/Pacific Islander), timing (2-4 weeks post resolution of symptoms vs. >30 days after infection), vaccination status (not vaccinated vs. predominantly vaccinated), or possibly viral strain.…”

Section: Discussioncontrasting

confidence: 99%

“…It has been shown previously that monocytes from acutely infected patients produce higher levels of proinflammatory cytokines and type I IFNs [14][15][16][17][18] . Similarly, monocytes in convalescent individuals have been shown to express increased levels of inflammatory genes [21][22][23][24] . There have been conflicting reports as to whether long COVID is associated with increased levels of proinflammatory cytokines 32 33-35 or whether it is characterized by cytokine deficiencies 36 .…”

Section: Expression Of Proinflammatory Cytokines Is Decreased In Conv...mentioning

confidence: 99%

“…The fate of monocytes during the convalescent phase of COVID-19 is less well understood. In some studies, patients who fully recovered from acute COVID-19 infection were found to have increased circulating non-classical monocytes and decreased classical monocytes during convalescence [19][20][21] . In addition, these studies showed that monocytes in convalescent individuals display increased levels of inflammatory genes [21][22][23][24] , antigen presentation molecules, including HLA-DQA and HLA-DPA 20 , and the activation marker CD169 21 .…”

Section: Introductionmentioning

confidence: 99%

“…In some studies, patients who fully recovered from acute COVID-19 infection were found to have increased circulating non-classical monocytes and decreased classical monocytes during convalescence [19][20][21] . In addition, these studies showed that monocytes in convalescent individuals display increased levels of inflammatory genes [21][22][23][24] , antigen presentation molecules, including HLA-DQA and HLA-DPA 20 , and the activation marker CD169 21 . However, other studies have demonstrated a decrease in monocyte percentages in convalescent individuals including those who had severe disease 25,26 .…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Reduced Monocyte Proportions and Responsiveness in Convalescent COVID-19 Patients

Ravkov,

Williams,

Elgort

et al. 2023

Preprint

View full text Add to dashboard Cite

The clinical manifestations of acute severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection and COVID-19 suggest a dysregulation of the host immune response that leads to inflammation, thrombosis, and organ dysfunction. It is less clear whether these dysregulated processes persist during the convalescent phase of disease or during long COVID. We investigated the effects of SARS-CoV-2 infection on the proportions of classical, intermediate, and non-classical monocytes, their activation status, and their functional properties in convalescent COVID-19 patients and uninfected control subjects. We found that the percentage of total monocytes was decreased in convalescent COVID-19 patients compared to uninfected controls. This was due to decreased intermediate and non-classical monocytes. Classical monocytes from convalescent COVID-19 patients demonstrated a decrease in activation markers, such as CD56, in response to stimulation with bacterial lipopolysaccharide (LPS). In addition, classical monocytes from convalescent COVID-19 patients showed decreased expression of CD142 (tissue factor), which can initiate the extrinsic coagulation cascade, in response to LPS stimulation. Finally, we found that monocytes from convalescent COVID-19 patients produced less TNF-α and IL-6 in response to LPS stimulation, than those from uninfected controls. In conclusion, SARS-CoV-2 infection exhibits a clear effect on the relative proportions of monocyte subsets, the activation status of classical monocytes, and proinflammatory cytokine production that persists during the convalescent phase of disease.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Expression Of Proinflammatory Cytokines Is Decreased In Conv...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Reduced Monocyte Proportions and Responsiveness in Convalescent COVID-19 Patients

Ravkov,

Williams,

Elgort

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Elevated Circulating Monocytes and Monocyte Activation in Pulmonary Post-Acute Sequelae of Sars-Cov-2 Infection

Cited by 1 publication

References 0 publications

Reduced Monocyte Proportions and Responsiveness in Convalescent COVID-19 Patients

Reduced Monocyte Proportions and Responsiveness in Convalescent COVID-19 Patients

Contact Info

Product

Resources

About