Elevated concentrations of cardiac troponins are associated with severe coronary artery calcification in asymptomatic haemodialysis patients

Jung, Hyo Won; Ran, Kyung; Han, Heon

doi:10.1093/ndt/gfh488

Cited by 34 publications

(24 citation statements)

References 23 publications

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“…10,[39][40][41] The association of elevated cTnT and cTnI levels with coronary artery calcification in asymptomatic dialysis patients may represent this link between troponins and mortality in the vascular frame. 42 We observed a significant positive correlation between the CA-IMT and the cTnI levels within the patient group. Hojs et al demonstrated that CA-IMT values were significantly higher in patients with elevated cTnT levels.…”

Section: Renal Failurementioning

confidence: 52%

Predictive markers of asymptomatic atherosclerosis in end-stage renal disease patients

Mutluay¹,

Konca²,

Erten³

et al. 2010

Renal Failure

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Objective: Uremia is associated with accelerated atherosclerosis and increased cardiovascular mortality in patients with end-stage renal disease (ESRD). Cardiac injury markers, such as myoglobin, creatine kinase-MB (CK-MB), or troponins, frequently used to recognize acute coronary events, may be falsely elevated in this patient group. In this study, our aim was to (i) test serum levels of myoglobin, CK-MB, and troponin I (cTnI) in ESRD patients without coronary artery disease (CAD) and compare the results with healthy controls and (ii) to investigate the association between these markers and carotid artery intima-media thickness (CA-IMT), high-sensitive C-reactive protein (hs-CRP), and serum uric acid (SUA) levels in ESRD patients. Materials and methods: Fifty-two ESRD patients (25 hemodialysis and 27 peritoneal dialysis) and 17 healthy controls were included in the study. Serum levels of myoglobin, CK-MB, and cTnI were measured and ultrasonographic CA-IMT was determined in all participants. SUA and hs-CRP levels were only measured in the ESRD group. Results: Serum myoglobin, CK-MB levels, and the mean CA-IMT were significantly higher in ESRD group (p < 0.01), whereas cTnI levels were not different compared to healthy controls (p = 0.70). There was also a positive correlation between CA-IMT and cTnI levels (p = 0.003, r = 0.35) and CA-IMT and hs-CRP (p = 0.03, r = 0.30) or SUA levels (p = 0.003, r = 0.43). Conclusion: cTnI may serve as a more sensitive marker in detecting cardiovascular events in patients with renal failure. Besides the traditional risk factors of atherosclerosis, cTnI, hs-CRP, and SUA may have a predictive role in recognizing premature atherosclerosis in ESRD patients.

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Section: Renal Failurementioning

confidence: 52%

Predictive markers of asymptomatic atherosclerosis in end-stage renal disease patients

Mutluay¹,

Konca²,

Erten³

et al. 2010

Renal Failure

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“…81 cTnT was also shown to correlate with the degree of coronary artery calcification in asymptomatic HD patients. 85 In addition, Fahie-Wilson et al 86 found that circulating cTnT detected in patients with kidney failure was predominantly the freeintact form, as in patients with acute coronary syndrome, lending further evidence that circulating cTnT in patients with ESRD is indeed a marker of cardiac pathology.…”

Section: Mechanisms Of Elevated Cardiac Troponins In Patients With Esrdmentioning

confidence: 98%

Use of Cardiac Biomarkers in End-Stage Renal Disease

Wang¹,

Lai²

2008

Journal of the American Society of Nephrology

183

139

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“…Jung et al reported an independent association of cTns with the degree of severity of coronary artery calcification detected by multirow spiral computed tomography in 38 asymptomatic chronic HD patients. 47 One large study 48 found that dialysis patients with elevated cTnT levels were more likely to have severe angiographic coronary disease. deFillippi et al found that a high level of cTnT (> median) vs a low level of cTnT remained an independent predictor of multivessel disease (prevalence ratio, 3.7 fold) after adjustment for age and history of clinical CAD in stable patients undergoing long-term HD.…”

Section: Ctns In Ckd/esrdmentioning

confidence: 99%

Heart Failure, Chronic Kidney Disease, and Biomarkers - An Integrated Viewpoint -

Iwanaga

Miyazaki

2010

Circ J

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Chronic kidney disease (CKD) is frequently associated with a progressive decrease in the glomerular filtration rate, which leads to endstage renal disease (ESRD). Heart failure (HF) is a complex syndrome rather than a primary diagnosis, and considered as the endpoint of all cardiovascular disorders. It is the leading cause of death among the cardiovascular diseases in patients with CKD and ESRD. There is some interaction between the heart and kidney (the so-called "cardiorenal syndrome"), and HF patients with the complication of CKD or ESRD show a worse prognosis. Thus, early diagnosis and aggressive management of HF are needed in patients with CKD and ESRD. A number of biomarkers appear to have growing clinical importance and are reported for detection and stratification of HF. Although HF and CKD have a close interrelationship, the utility of the biomarkers has not been adequately studied with regard to the relationship with renal dysfunction. This paper reviews of the current evidence about laboratory biomarkers in patients with HF or CKD, emphasizing the emerging cardiac biomarkers (ie, BNPs and cardiac troponins), and the biomarkers of renal injury (ie, cystatin C and neutrophil gelatinase-associated lipocalin). Furthermore, it discusses the potential role of these markers in terms of heart -kidney interactions and their utility in the diagnostic and therapeutic strategies for cardiorenal syndrome. (Circ J 2010; 74: 1274 - 1282

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Elevated concentrations of cardiac troponins are associated with severe coronary artery calcification in asymptomatic haemodialysis patients

Abstract: Elevated concentrations of cTnT and cTnI, but not BNP or CK-MB, were independently associated with the degree of severity of CAC in asymptomatic haemodialysis patients.

Cited by 34 publications

References 23 publications

Predictive markers of asymptomatic atherosclerosis in end-stage renal disease patients

Predictive markers of asymptomatic atherosclerosis in end-stage renal disease patients

Use of Cardiac Biomarkers in End-Stage Renal Disease

Heart Failure, Chronic Kidney Disease, and Biomarkers - An Integrated Viewpoint -

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