Elevated cord serum manganese level is associated with a neonatal high ponderal index

Yu, Xiaodan; Cao, Linfeng; Yu, Xiaogang

doi:10.1016/j.envres.2012.11.002

Cited by 84 publications

(58 citation statements)

References 23 publications

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“…This study had a small sample size (n = 101) and the maternal Mn level (16.3 μg/L) was much lower than that in our study [22]. In Shanghai study [23], serum Mn from both cord blood and maternal blood were used as biomarkers, with the median maternal and cord serum level of 2.8 μg/dL and 4.0 μg/dL, respectively. The authors examined the relationship between cord serum Mn and birth weight by multiple regression, and did not find a significant association between them, although they found a negative relationship and nonlinear relationship between cord serum Mn and birth length and Ponderal index, respectively [23].…”

Section: Discussionmentioning

confidence: 69%

Maternal blood manganese level and birth weight: a MOCEH birth cohort study

Eum

Cheong

et al. 2014

Environ Health

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BackgroundManganese (Mn) is an essential trace element for humans and animals, but excess intake of Mn can lead to adverse developmental outcome. Few studies have investigated the effects of deficiency or excess of Mn on the human foetus. In this study, we assessed the quantitative relationship between maternal blood Mn and birth weight of a newborn.MethodsWe performed analysis on 331 full-term, live birth singleton mother-infant pairs enrolled from July 2007 to December 2009 in the Mother and Children’s Environmental Health (MOCEH) study in Korea. A questionnaire on general characteristics, a review of medical records, and maternal whole blood Mn analysis were performed at full-term pregnancy. We evaluated the relationship between maternal blood level of Mn and the birth outcome using logistic regression and generalised additive model.ResultsThe mean Mn concentration in whole maternal blood was 22.5 μg/L. We found a curvilinear relationship between maternal blood Mn and birth weight after adjusting for potential confounders. Birth weight peaked at the maternal blood Mn level of 30 and 35 μg/L. An increased probability of birth weight below 3000 g was observed at both below 16.9 μg/L (odds ratio = 2.77, 95% CI: 0.89–8.65) and above 26.9 μg/L of maternal blood Mn level (odds ratio = 2.66, 95% CI: 0.84–8.08).ConclusionsOur study found that both extreme level of maternal Mn level was associated with lower birth weight outcome in a nonlinear fashion.

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Section: Discussionmentioning

confidence: 69%

Maternal blood manganese level and birth weight: a MOCEH birth cohort study

Eum

Cheong

et al. 2014

Environ Health

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“…Higher concentrations of manganese were observed in umbilical cord blood than in maternal blood (Table 1). A concentration of manganese equal to or greater than 5 μg/L in the cord blood was correlated with a higher PI [18].…”

Section: Discussionmentioning

confidence: 92%

“…An extensive study by Yu et al attempted to correlate manganese concentrations in maternal blood and umbilical cord blood with neonatal birth weight and birth length, using the ponderal index (PI) [18]. Higher concentrations of manganese were observed in umbilical cord blood than in maternal blood (Table 1).…”

Section: Discussionmentioning

confidence: 99%

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Selected trace elements concentrations in pregnancy and their possible role — literature review

et al. 2017

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The aim of this study was to review the role of selected trace elements in pregnancy and fetal development. Citations related to the role of iron (Fe), zinc (Zn), manganese (Mn), copper (Cu) and selenium (Se) during pregnancy were searched in PubMed, Medline, Web of Science, using keywords and MeSH terms. Inadequate supply of trace elements can cause abnormalities of fetal development and predispose a child to disorders later on in life. Trace elements are the key elements of complex enzymes responsible for the modulation of the antioxidant defense system of the organism. It has been suggested that there is a correlation between reduced levels of trace elements essential for antioxidant function in the body of pregnant women, and an increased risk of developing preeclampsia. Trace elements are components of numerous regulatory enzymes and hormones essential to the division and differentiation of fetal cells and their further development. Mineral deficiencies in pregnant women can cause birth defects of the central nervous system, and growth disorders. Future research should be directed to explain the interaction between trace elements, and establish the optimum levels of macro and micronutrients supplementation, as well as determine the reference values for trace elements in the maternal serum, umbilical cord blood and amniotic fluid.

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“…Zota and colleagues found no association between birth weight and manganese concentration in cord blood but reported an inverted U-shaped relationship with maternal blood, where birth weight was significantly decreased at both extremes (high and low manganese concentrations). 50 Yu and colleagues observed an association between high cord blood manganese concentration and the pondoral index, 51 which is an anthropometric measure commonly used in pediatric populations because it better accounts for height variations than does body mass index, may predict adult obesity and cardiovascular disease risk, and may be indicative of glucose intolerance.…”

Section: Birth Outcomesmentioning

confidence: 98%

Developmental Effects of Manganese

Langevin¹,

Haynes²

2014

Manganese in Health and Disease

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The impact of manganese on human development is paradoxical, as it is both an essential nutrient and a toxicant. Current evidence indicates that manganese toxicity follows an inverted U-shaped curve where both low and high biological levels are associated with negative health consequences. Such adverse effects may be most severe in children at the earliest developmental stages, owing to their immature capacity for homeostatic control and underdeveloped blood–brain barrier, particularly in terms of neurodevelopment, bone development and growth, and possibly sexual maturation. This chapter summarizes the current body of literature surrounding these developmental effects.

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Elevated cord serum manganese level is associated with a neonatal high ponderal index

Cited by 84 publications

References 23 publications

Maternal blood manganese level and birth weight: a MOCEH birth cohort study

Maternal blood manganese level and birth weight: a MOCEH birth cohort study

Selected trace elements concentrations in pregnancy and their possible role — literature review

Developmental Effects of Manganese

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