Elevated cortisol levels and changes in thymus metabolism in burn trauma

Sajdel-Sulkowska, E M; Kumar, Amit; Clairmont, G.; Antoon, Alia Y.; Burke, John F.

doi:10.1016/0305-4179(78)90059-1

Cited by 4 publications

(1 citation statement)

References 22 publications

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“…In harmony with cortisol level changes lymphocyte counts showed significant decrease in HiR vs. LR individuals (Figure 3C). T-cells developing in the thymus (termed thymocytes) are especially sensitive to cortisol and readily undergo apoptosis (Sajdel-Sulkowska et al, 1978). However, thymus function (naïve T-cell production) has been reported to show improvement in response to moderate regular exercise (Duggal et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Artificial Neural Network Correlation and Biostatistics Evaluation of Physiological and Molecular Parameters in Healthy Young Individuals Performing Regular Exercise

et al. 2019

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Studies support that regular physical activity (PA) decelerates senescence-related decline of physiological and molecular parameters in the elderly. We have addressed the other end of this spectrum: healthy and young, inactive individuals participated in a 6-month long personal trainer-guided lifestyle program. We have measured physiological and molecular parameters (differentiating high- and low responders) and their correlation with PA (sedentary status). Cluster analysis helped to distinguish individuals with high- or low PA and differentiate high- and low-responders of each parameter. The assessed cardiovascular parameters (heart rate, blood pressure, 6-min walking distance, relative VO2max), body composition parameters (body fat and muscle mass percentage) metabolic parameters (glucose, insulin, HDL, LDL), immune parameters (cortisol, CRP, lymphocyte counts, hTREC) all showed improvement. Artificial neural network analysis (ANN) showed correlation efficiencies of physiological and molecular parameters using a concept-free approach. ANN analysis appointed PA as the mastermind of molecular level changes. Besides sedentary status, insulin and hTREC showed significant segregation. Biostatistics evaluation also supported the schism of participants for their sedentary status, insulin concentration and hTREC copy number. In the future ANN and biostatistics, may predict individual responses to regular exercise. Our program reveals that high responder individuals of certain parameters may be low responders of others. Our data show that moderate regular PA is essential to counteract senescence in young and healthy individuals, despite individual differences in responsiveness. Such PA may not seem important in the everyday life of young and healthy adults, but shall become the base for healthy aging.

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Section: Discussionmentioning

confidence: 99%