“…TA-FRs are a new group of current-use flame retardants and have now become emerging chemicals of concern. , Two well-known examples include tris(2,3-dibromopropyl) isocyanurate (TDBP-TAZTO) − and 2,4,6-tris(2,4,6-tribromophenoxy)-1,3,5-triazine (TTBP-TAZ). , The production and use of TDBP-TAZTO first started in the 1980s, and the annual production has been up to 500 tons since 1996 in China, which has been widely detected in Chinese environmental samples. ,− TTBP-TAZ has been increasingly used in plastic products and electric and electronic equipment, which was previously reported to exhibit elevated concentrations in e-waste facilities and prevalence in residential houses. ,, Other TA-FRs, mainly including melamine and its derivatives, have been found in food and human biological samples. − Because China is the world’s largest producer and consumer of melamine, with its annual production up to 1.29 million tons in 2020, this raised special concern regarding kidney damage in humans, particularly for infants. , To date, previous studies, without exception, were limited to focusing on only one or a few TA-FRs in regional environments. Comprehensive screening for TA-FRs in environmental matrixes is necessary for better understanding their environmental and health risks.…”